Formulation and in vitro evaluation of theophylline-Eudragit® sustained-release tablets

The present work involves the formulation development, optimization and In-vitro evaluation of bilayer tablet containing Lansoprazole in the immediate release layer and Amoxycillin in the sustained release layer, using sodium starch glycolate as a super disintegrant for the immediate release layer and the hydrophilic matrix HPMC K100M, hydrophobic matrix Ethyl cellulose are used in the sustained release layer. Bilayer tablet showed as initial burst effect to provide dose of immediate release layer Lansoprazole to control the acid secretion level and the sustained release of Amoxycillin for 24 hours. Immediate and sustained release tablets were formulated by wet granulation method because of the poor flow property of the blends. The prepared bilayer tablet was evaluated for their precompression parameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drug content, swelling index, In-vitro floating studies and In-vitro drug release. The release of the lansoprazole from the immediate release layer was found to be 97.46 ± 0.15% in 15minutes. The release of Amoxycillin Trihydrate for the sustained release floating layer was found to be 98.25 ± 0.14% in 12 hours. Lansoprazole potentiate the effect of Amoxycillin. Hence the bilayer tablets of Lansoprazole and Amoxycillin were used to improve patient compliance towards the effective management of ulcer. Keywords: bilayer tablet, Lansoprazole, and Amoxycillin, sustained release

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In vitro Evaluation of Sustained-Release Tablets by Dual Channel Scintillation Counting

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600530324 ◽

1964 ◽

Vol 53 (3) ◽

pp. 340-341 ◽

Cited By ~ 6

Author(s):

K.O. Montgomery ◽

C.V. Flemming ◽

M.H. Weinswig ◽

R.F. Parke ◽

H.A. Swartz

Keyword(s):

Sustained Release ◽

Scintillation Counting ◽

In Vitro Evaluation ◽

Dual Channel ◽

Sustained Release Tablets

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Sustained Release Properties of Aminophylline Sustained Release Tablets Based on Exfoliated Graphite

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.1023.67 ◽

2014 ◽

Vol 1023 ◽

pp. 67-70

Author(s):

Lin Gao ◽

Ye Wei

Keyword(s):

Sustained Release ◽

Release Rate ◽

Exfoliated Graphite ◽

In Vitro Evaluation ◽

Graphite Content ◽

Vis Spectroscopy ◽

Sustained Release Tablets

This study attempted to develop sustained release tablets based on exfoliated graphite. The in vitro evaluation of the prepared tablets was carried out to study its sustained release properties by means of UV/VIS spectroscopy. The results show that the release rate of aminophylline decreases with the increase of the content of graphite for the aminophylline sustained release tablets based on exfoliated graphite. The graphite in the aminophylline sustained release tablets will delay the release of aminophylline when the exfoliated graphite content in the sustained release tablets is less than 25%, the graphite will prevent the release of a part of the aminophylline when the exfoliated graphite content exceeds 40%. The reproducibility of the prepared aminophylline sustained release tablets is acceptable.

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Preparation and in vitro evaluation of sulforaphane intragastric buoyant sustained-release tablets

Journal of Biotechnology ◽

10.1016/j.jbiotec.2008.07.113 ◽

2008 ◽

Vol 136 ◽

pp. S53 ◽

Cited By ~ 1

Author(s):

Qipeng Yuan ◽

Xiaodan Hou ◽

Hao Liang ◽

Chunfang Li

Keyword(s):

Sustained Release ◽

In Vitro Evaluation ◽

Sustained Release Tablets

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Formulation and Evaluation of Sustained Release Dosage Forms of Norfloxacin

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2018.11.6.6 ◽

2018 ◽

Vol 11 (6) ◽

pp. 4331-4337

Author(s):

C Suja ◽

Sismy C

Keyword(s):

Sustained Release ◽

Guar Gum ◽

In Vitro Release ◽

Angle Of Repose ◽

Prolonged Release ◽

Weight Variation ◽

Sustained Release Tablets ◽

Release Study ◽

Vitro Release

The goal of this study was to formulate and evaluate norfloxacin sustained release tablets. Norfloxacin sustained release tablets were prepared by wet granulation method using two polymers such as HPMC K 100 M (hydrophilic polymer) and guar gum (natural polymer) and with three polymer ratios (0.5, 1.0 and 1.5). The prepared granules were evaluated to preformulation studies such as angle of repose, bulk density, tapped density, bulkiness, compressibility index and Hauser’s ratio. All the parameters shows that the granules having good flow properties. Then the formulated tablets were taken to evaluation studies such as hardness, weight variation, friability, drug content and thickness. All the parameters were within the acceptable limits. IR spectral analysis showed that there was no interaction between the drug and polymers. The in vitro release study was performed in phosphate buffer pH 7.4 at 293 nm. The in vitro release study showed that if the polymer ratio is increased, then the release of the drug is prolonged. HPMC K 100M shows a prolonged release when compared to guar gum.

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Matrix Based Sustained Release Tablets of Carvedilol: Formulation and In-vitro Characterization

Drug Delivery Letters ◽

10.2174/2210303108666180227140554 ◽

2018 ◽

Vol 8 (2) ◽

pp. 153-158

Author(s):

Praveen Radhakrishnan ◽

Shinu Chacko ◽

Raman Saraswathi ◽

Palamadai Neelakantam Krishnan

Keyword(s):

Sustained Release ◽

In Vitro Characterization ◽

Sustained Release Tablets

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A study on the influence of the formulation factors on in vitro release of ketoprofen from sustained release tablets

Romanian Journal of Pharmaceutical Practice ◽

10.37897/rjphp.2021.1.6 ◽

2021 ◽

Vol 14 (1) ◽

pp. 41-48

Author(s):

Larisa Cimpoaie ◽

◽

Luca Liviu Rus ◽

Rareș Iuliu Iovanov ◽

◽

...

Keyword(s):

Sustained Release ◽

In Vitro Release ◽

Matrix Tablets ◽

Inert Matrix ◽

Sustained Release Tablets ◽

Formulation Factors ◽

Release Data ◽

Vitro Release ◽

Inert Matrix Tablets

Objectives. The aim of this study was to investigate the influence of formulation factors on in vitro release of ketoprofen from sustained release inert matrix tablets. Materials and methods. Laboratory scale, Ketoprofen sustained release inert matrix tablets were manufactured using Kollidon® SR as matrix formator, by direct tableting of powder blends. The influence of the formulation factors (X1 – matrix formator excipient and X2 – diluent type) on in vitro release of ketoprofen from sustained release tablets was studied by using a full factorial 23 experimental plan. Outcomes. Pharmacotechnical characterization of manufactured laboratory scale batches was performed and all 12 batches fulfilled European Pharmacopeia requests. In vitro release showed a sustained release profile in all cases. Variance analysis (ANOVA) showed a good correlation between experimental conditions and answers. In vitro release testing was performed in phosphate buffer pH = 7.4. Percentage release was determined spectrophotometrically at 258 nm. A decrease in the rate of in vitro release was registered, up to 4 h and 6 h when lactose DC and mannitol DC were used as diluents, respectively. Isomalt DC has increased the rate of in vitro release up to 6 h. Conclusions. In vitro release data, corresponding to formulation N1 shoed a good fitting with Weitbull, Korshmeyer-Peppas and Higuchi models while in vitro release data corresponding to formulation N8 presented a good fitting with Weitbull and Korsmeyer-Peppas. In case of formulations N1 and N8 a non-Fickian diff usion mechanism seems to be involved in drug release from the matrix tablets.

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