scholarly journals Assessment of implantable drug delivery technology: poly (3-hydroxybutyrate) / polypropylene glycol films containing simvastatin

2021 ◽  
Vol 26 (4) ◽  
Author(s):  
Lays Fernanda Nunes Dourado ◽  
Amauri Pierucci ◽  
Juan Pedro Bretas Roa ◽  
Álvaro Dutra de Carvalho Júnior
Keyword(s):  
Drug Delivery ◽  
Polypropylene Glycol ◽  
Delivery Technology

Recent Advances in Gastric Floating Drug Delivery Technology: A Review

2013 ◽  
Vol 10 (3) ◽  
pp. 286-298 ◽  
Author(s):  
Rakesh Pahwa ◽  
Seema Bisht ◽  
Vipin Kumar ◽  
Kanchan Kohli
Keyword(s):  
Drug Delivery ◽  
Recent Advances ◽  
Floating Drug Delivery ◽  
Delivery Technology

scholarly journals Flexible Polymeric Nanosized Micelle for Ophthalmic Drug Delivery: Research Progress in Recent Three Years

2021 ◽  
Author(s):  
Zhiguo Li ◽  
Mingting Liu ◽  
Lingjie Ke ◽  
Li-Juan Wang ◽  
Caisheng Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Complex Structure ◽  
Research Progress ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Delivery Technology

The eye is a complex structure with a variety of anatomical barriers and clearance mechanisms, so the provision of safe and effective ophthalmic drug delivery technology is a major challenge....

Company News

2003 ◽  
Vol 07 (10) ◽  
pp. 496-502
Keyword(s):  
Drug Delivery ◽  
Japanese Firm ◽  
Inflammatory Drug ◽  
Synthetic Dna ◽  
Business News ◽  
Medical Standard ◽  
Anti Inflammatory ◽  
Delivery Technology

Prima Subsidiary Breakthrough in Malaria Experiments. Biota Achieves HIV Drug Breakthrough. China Business News. Sino-French Collaboration. US to Export Synthetic DNA to Japanese Firm. Genesis and EvoGenix Collaborates to Discover Anti-Inflammatory Drug. Biomedical Strategy Consultants Marches into Europe. Athelas and MerLion to Work Together on Anti-Infectives. BioPhotoFullerenes to Open HQ in Taiwan. Kiotek to Produce Medical-Standard Chitosan. TaiGen to Buy Microbubble Drug Delivery Technology. Intel Launches Itanium2 Server to Address Bioinformatics Market.

scholarly journals The TAT Protein Transduction Domain as an Intra-Articular Drug Delivery Technology

Cartilage ◽  
2020 ◽  
pp. 194760352095939
Author(s):  
Sarah E. Mailhiot ◽  
Matthew A. Thompson ◽  
Akiko E. Eguchi ◽  
Sabrina E. Dinkel ◽  
Martin K. Lotz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Genetic Recombination ◽  
Great Promise ◽  
Tat Protein ◽  
Binding Studies ◽  
Osteoarthritic Cartilage ◽  
Peptide Transduction ◽  
Delivery Technology

Objective Intra-articular drug delivery holds great promise for the treatment of joint diseases such as osteoarthritis. The objective of this study was to evaluate the TAT peptide transduction domain (TAT-PTD) as a potential intra-articular drug delivery technology for synovial joints. Design Experiments examined the ability of TAT conjugates to associate with primary chondrocytes and alter cellular function both in vitro and in vivo. Further experiments examined the ability of the TAT-PTD to bind to human osteoarthritic cartilage. Results The results show that the TAT-PTD associates with chondrocytes, is capable of delivering siRNA for chondrocyte gene knockdown, and that the recombinant enzyme TAT-Cre is capable of inducing in vivo genetic recombination within the knee joint in a reporter mouse model. Last, binding studies show that osteoarthritic cartilage preferentially uptakes the TAT-PTD from solution. Conclusions The results suggest that the TAT-PTD is a promising delivery strategy for intra-articular therapeutics.

Proprietary Rel-Ease™ drug delivery technology: opportunity for sustained delivery of peptides, proteins and small molecules

2006 ◽  
Vol 3 (5) ◽  
pp. 663-675 ◽  
Author(s):  
Ming Ye ◽  
Gajanan Bhat ◽  
Kevin A Johnston ◽  
Heow Tan ◽  
Marc Garnick
Keyword(s):  
Drug Delivery ◽  
Small Molecules ◽  
Sustained Delivery ◽  
Delivery Technology

scholarly journals Effects of Atelocollagen Formulation Containing Oligonucleotide on Endothelial Permeability

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Koji Hanai ◽  
Takashi Kojima ◽  
Mika Ota ◽  
Jun Onodera ◽  
Norimasa Sawada
Keyword(s):  
Drug Delivery ◽  
Size Structure ◽  
Biological Effects ◽  
Adherens Junction ◽  
Endothelial Permeability ◽  
Molecular Size ◽  
P38 Map Kinase ◽  
Delivery Technology ◽  
Junction Proteins

Atelocollagen is a major animal protein that is used as a highly biocompatible biomaterial. To date, atelocollagen has been used as an effective drug delivery technology to sustain the release of antitumor proteins and to enhance the antitumor activity of oligonucleotides in in vivo models. However, the biological effects of this technology are not fully understood. In the present study, we investigated the effects of atelocollagen on endothelial paracellular barrier function. An atelocollagen formulation containing oligonucleotides specifically increased the permeability of two types of endothelial cells, and the change was dependent on the molecular size, structure of the oligonucleotides used and the concentrations of the oligonucleotide and atelocollagen in the formulation. An immunohistochemical examination revealed that the formulation had effects on the cellular skeleton and intercellular structure although it did not affect the expression of adherens junction or tight junction proteins. These changes were induced through p38 MAP kinase signaling. It is important to elucidate the biological functions of atelocollagen in order to be able to exploit its drug delivery properties.

Track M. Drug Delivery Technology

2016 ◽  
Vol 61 (s1) ◽  
Author(s):  
Wiebke Kempin ◽  
Christian Franz ◽  
Werner Weitschies ◽  
Anne Seidlitz
Keyword(s):  
Drug Delivery ◽  
Delivery Technology
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