Computational Insights into the Molecular Mechanism of the High Immunomodulatory Activity of LZ-8 Protein Isolated from the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes)

2018 ◽  
Vol 20 (6) ◽  
pp. 537-548 ◽  
Author(s):  
Da-Peng Bao ◽  
Rui Bai ◽  
Ying-Nv Gao ◽  
Ying-Ying Wu ◽  
Ying Wang
Keyword(s):  
Molecular Mechanism ◽  
Ganoderma Lucidum ◽  
Immunomodulatory Activity ◽  
Medicinal Mushroom

scholarly journals Novel Application of Immunomodulatory Mushroom Polysaccharide (β-Glucan) and Triterpenes for Diabetic Wound Care

2020 ◽  
Author(s):  
Shiu-Nan Chen ◽  
Yu-Sheng Wu ◽  
Sherwin Chen ◽  
Ya-Chin Chang ◽  
Chung-Lun Lu
Keyword(s):  
Wound Healing ◽  
Ganoderma Lucidum ◽  
Cellular Proliferation ◽  
Wound Care ◽  
Immunomodulatory Activity ◽  
Diabetic Patients ◽  
Medicinal Mushroom ◽  
Positive Effects ◽  
Inflammatory Status ◽  
Healing Wound

β-Glucan and triterpenes are two important derivative compounds from traditional medicinal mushroom, such as Ganoderma lucidum and Antrodia cinnamomea. β-glucan and triterpenes are considered to have immunoregulatory properties in disease treatment for long years. The immunoregulatory effects are usually activated through some transcription of pro-inflammatory genes and possess immunomodulatory activity. Difficulty in healing wound now is a common condition that occurred in diabetic patients, and the physiological hyperglycemic status of diabetic patients resulting in the wounds continue to produce an inflammatory response. Thus, we hope to use β-glucan and triterpenes for difficult wound healing that possess immunomodulatory activity on the wound micro-environment and stimulate the positive effects on healing. In this chapter, these two important derivative compounds from traditional medicinal mushroom were examined by diabetic mammal’s wound healing models. In these models, the skin wounds’ microenvironment is expected close to diabetic foot, suffering in hyperglycemic and inflammatory status. The results are clearly presented, with the immunomodulatory effects from mushroom β-glucan and triterpenes that involved in modulating the cell-mediated immune system to cause cellular proliferation and further to introduce healing performance of the chronic inflammation wounds.

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