Frequency-Dependent Modulation of Short-Term Plasticity of GABAergic Synaptic Transmission

2018 ◽  
Vol 9 (2) ◽  
pp. 119-126
Author(s):  
Oksana P. Kolesnyk ◽  
Svetlana A. Fedulova ◽  
Mycola S. Veselovsky
Keyword(s):  
Synaptic Transmission ◽  
Short Term ◽  
Frequency Dependent ◽  
Short Term Plasticity ◽  
Gabaergic Synaptic Transmission

scholarly journals , FREQUENCY-DEPENDENT MODULATION OF SHORT-TERM PLASTICITY OF GABAERGIC SYNAPTIC TRANSMISSION

2017 ◽  
Vol 63 (4) ◽  
pp. 10-16
Author(s):  
О.P. Кolesnyk ◽  
◽  
S. А. Fedulova ◽  
N. S. Veselovsky ◽  
◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Short Term ◽  
Frequency Dependent ◽  
Short Term Plasticity ◽  
Gabaergic Synaptic Transmission

scholarly journals Retinohypothalamic Tract Synapses in the Rat Suprachiasmatic Nucleus Demonstrate Short-Term Synaptic Plasticity

2010 ◽  
Vol 103 (5) ◽  
pp. 2390-2399 ◽  
Author(s):  
Mykhaylo G. Moldavan ◽  
Charles N. Allen
Keyword(s):  
Synaptic Transmission ◽  
Suprachiasmatic Nucleus ◽  
Ganglion Cells ◽  
Brain Slices ◽  
Release Mechanism ◽  
Dependent Manner ◽  
Short Term ◽  
Frequency Dependent ◽  
Short Term Plasticity ◽  
Retinohypothalamic Tract

The master circadian pacemaker located in the suprachiasmatic nucleus (SCN) is entrained by light intensity–dependent signals transmitted via the retinohypothalamic tract (RHT). Short-term plasticity at glutamatergic RHT–SCN synapses was studied using stimulus frequencies that simulated the firing of light sensitive retinal ganglion cells. The evoked excitatory postsynaptic current (eEPSC) was recorded from SCN neurons located in hypothalamic brain slices. The eEPSC amplitude was stable during 0.08 Hz stimulation and exhibited frequency-dependent short-term synaptic depression (SD) during 0.5 to 100 Hz stimulus trains in 95 of 99 (96%) recorded neurons. During SD the steady-state eEPSC amplitude decreased, whereas the cumulative charge transfer increased in a frequency-dependent manner and saturated at 20 Hz. SD was similar during subjective day and night and decreased with increasing temperature. Paired-pulse stimulation (PPS) and voltage-dependent Ca2+ channel (VDCC) blockers were used to characterize a presynaptic release mechanism. Facilitation was present in 30% and depression in 70% of studied neurons during PPS. Synaptic transmission was reduced by blocking both N- and P/Q-type presynaptic VDCCs, but only the N-type channel blocker significantly relieved SD. Aniracetam inhibited AMPA receptor desensitization but did not alter SD. Thus we concluded that SD is the principal form of short-term plasticity at RHT synapses, which presynaptically and frequency-dependently attenuates light-induced glutamatergic RHT synaptic transmission protecting SCN neurons against excessive excitation.

scholarly journals A General Model of Synaptic Transmission and Short-Term Plasticity

Neuron ◽  
2009 ◽  
Vol 62 (4) ◽  
pp. 539-554 ◽  
Author(s):  
Bin Pan ◽  
Robert S. Zucker
Keyword(s):  
Synaptic Transmission ◽  
General Model ◽  
Short Term ◽  
Short Term Plasticity

Synaptic transmission and short-term plasticity at the calyx of Held synapse revealed by multielectrode array recordings

2008 ◽  
Vol 174 (2) ◽  
pp. 227-236 ◽  
Author(s):  
Martin D. Haustein ◽  
Thomas Reinert ◽  
Annika Warnatsch ◽  
Bernhard Englitz ◽  
Beatrice Dietz ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Multielectrode Array ◽  
Short Term ◽  
Calyx Of Held ◽  
Short Term Plasticity ◽  
Array Recordings

Pre- and Post-Synaptically Induced Short-Term Plasticity of GABA-ergic Synaptic Transmission

2005 ◽  
Vol 37 (3) ◽  
pp. 261-272 ◽  
Author(s):  
M. V. Storozhuk ◽  
S. Yu. Ivanova ◽  
P. G. Kostyuk
Keyword(s):  
Synaptic Transmission ◽  
Short Term ◽  
Short Term Plasticity

scholarly journals Short-Term Plasticity in Cortical GABAergic Synapses on Olfactory Bulb Granule Cells Is Modulated by Endocannabinoids

2021 ◽  
Vol 15 ◽  
Author(s):  
Fu-Wen Zhou ◽  
Adam C. Puche
Keyword(s):  
Olfactory Bulb ◽  
Sensory Processing ◽  
Granule Cell ◽  
Granule Cells ◽  
Cb1 Receptor ◽  
Granule Cell Layer ◽  
Short Term ◽  
Frequency Dependent ◽  
Short Term Plasticity ◽  
Cortical Feedback

Olfactory bulb and higher processing areas are synaptically interconnected, providing rapid regulation of olfactory bulb circuit dynamics and sensory processing. Short-term plasticity changes at any of these synapses could modulate sensory processing and potentially short-term sensory memory. A key olfactory bulb circuit for mediating cortical feedback modulation is granule cells, which are targeted by multiple cortical regions including both glutamatergic excitatory inputs and GABAergic inhibitory inputs. There is robust endocannabinoid modulation of excitatory inputs to granule cells and here we explored whether there was also endocannabinoid modulation of the inhibitory cortical inputs to granule cells. We expressed light-gated cation channel channelrhodopsin-2 (ChR2) in GABAergic neurons in the horizontal limb of the diagonal band of Broca (HDB) and their projections to granule cells in olfactory bulb. Selective optical activation of ChR2 positive axons/terminals generated strong, frequency-dependent short-term depression of GABAA-mediated-IPSC in granule cells. As cannabinoid type 1 (CB1) receptor is heavily expressed in olfactory bulb granule cell layer (GCL) and there is endogenous endocannabinoid release in GCL, we investigated whether activation of CB1 receptor modulated the HDB IPSC and short-term depression at the HDB→granule cell synapse. Activation of the CB1 receptor by the exogenous agonist Win 55,212-2 significantly decreased the peak amplitude of individual IPSC and decreased short-term depression, while blockade of the CB1 receptor by AM 251 slightly increased individual IPSCs and increased short-term depression. Thus, we conclude that there is tonic endocannabinoid activation of the GABAergic projections of the HDB to granule cells, similar to the modulation observed with glutamatergic projections to granule cells. Modulation of inhibitory synaptic currents and frequency-dependent short-term depression could regulate the precise balance of cortical feedback excitation and inhibition of granule cells leading to changes in granule cell mediated inhibition of olfactory bulb output to higher processing areas.

scholarly journals Reexamination of N-terminal domains of Syntaxin-1 in vesicle fusion from central murine synapses

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Gülçin Vardar ◽  
Andrea Salazar-Lázaro ◽  
Marisa M Brockmann ◽  
Marion Weber-Boyvat ◽  
Sina Zobel ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Neurotransmitter Release ◽  
Null Mouse ◽  
General View ◽  
Binding Modes ◽  
Short Term ◽  
Short Term Plasticity ◽  
Open Conformation ◽  
Vesicular Release ◽  
Mouse Model System

Syntaxin-1 (STX1) and Munc18-1 are two requisite components of synaptic vesicular release machinery, so much so synaptic transmission cannot proceed in their absence. They form a tight complex through two major binding modes: through STX1's N-peptide and through STX's closed conformation driven by its Habc- domain. However, physiological roles of these two reportedly different binding modes in synapses are still controversial. Here we characterized the roles of STX1's N-peptide, Habc-domain, and open conformation with and without N-peptide deletion using our STX1-null mouse model system and exogenous reintroduction of STX1A mutants. We show, on the contrary to the general view, that the Habc-domain is absolutely required and N-peptide is dispensable for synaptic transmission. However, STX1A's N-peptide plays a regulatory role, particularly in the Ca2+-sensitivity and the short-term plasticity of vesicular release, whereas STX1's open-conformation governs the vesicle fusogenicity. Strikingly, we also show neurotransmitter release still proceeds when the two interaction modes between STX1A and Munc18-1 are presumably intervened, necessitating a refinement of the conceptualization of STX1A-Munc18-1 interaction.

Structural Contributions to Short-Term Synaptic Plasticity

2004 ◽  
Vol 84 (1) ◽  
pp. 69-85 ◽  
Author(s):  
MATTHEW A. XU-FRIEDMAN ◽  
WADE G. REGEHR
Keyword(s):  
Synaptic Plasticity ◽  
Synaptic Transmission ◽  
Synaptic Strength ◽  
Short Term ◽  
Ongoing Activity ◽  
Short Term Plasticity ◽  
Synaptic Ultrastructure

Xu-Friedman, Matthew A., and Wade G. Regehr. Structural Contributions to Short-Term Synaptic Plasticity. Physiol Rev 84: 69–85, 2004; 10.1152/physrev.00016.2003.—Synaptic ultrastructure is critical to many basic hypotheses about synaptic transmission. Various aspects of synaptic ultrastructure have also been implicated in the mechanisms of short-term plasticity. These forms of plasticity can greatly affect synaptic strength during ongoing activity. We review the evidence for how synaptic ultrastructure may contribute to facilitation, depletion, saturation, and desensitization.

Interactions Between Asynchronous Release and Short-Term Plasticity in the Nucleus Accumbens Slice

2006 ◽  
Vol 95 (3) ◽  
pp. 2020-2023 ◽  
Author(s):  
Gregory O. Hjelmstad
Keyword(s):  
Nucleus Accumbens ◽  
Synaptic Transmission ◽  
Short Term ◽  
Short Term Plasticity ◽  
Releasable Pool ◽  
Readily Releasable Pool ◽  
Glutamate Synapses ◽  
Asynchronous Release

Glutamate synapses in the nucleus accumbens (NAc) display asynchronous release in response to trains of stimulation. However, it is unclear what role this asynchronous release plays in synaptic transmission in this nucleus. This process was studied, specifically looking at the interaction between short-term depression and asynchronous release. These results indicate that synchronous and asynchronous release do not compete for a depleted readily releasable pool of vesicles.

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