scholarly journals Estrogen receptor and aryl hydrocarbon receptor signaling pathways

2006 ◽  
Vol 4 (1) ◽  
pp. nrs.04016 ◽  
Author(s):  
Jason Matthews ◽  
Jan-Åke Gustafsson
Keyword(s):  
Estrogen Receptor ◽  
Transcription Factors ◽  
Estrogen Receptors ◽  
Aryl Hydrocarbon Receptor ◽  
Nuclear Receptors ◽  
Nuclear Receptor ◽  
Target Genes ◽  
Xenobiotic Metabolism ◽  
Positive Role ◽  
Aryl Hydrocarbon

Estrogen receptors (ERs) and the aryl hydrocarbon receptor (AhR) are ligand activated transcription factors and members of the nuclear receptor and bHLH-PAS superfamilies, respectively. AhR is involved in xenobiotic metabolism and in mediating the toxic effects of dioxin-like compounds. Crosstalk has been observed among AhR and nuclear receptors, but has been most well studied with respect to ER signaling. Activated AhR inhibits ER activity through a number of different mechanisms, whereas ERα has been reported to have a positive role in AhR signaling. Here we will discuss recent data revealing that dioxin bound AhR recruits ERα to AhR regulated genes. We will also consider the implications of ER recruitment to AhR target genes on ER and AhR signaling.

scholarly journals Nuclear receptors, their coactivators and modulation of transcription.

1999 ◽  
Vol 46 (1) ◽  
pp. 77-89 ◽  
Author(s):  
M Manteuffel-Cymborowska
Keyword(s):  
Transcription Factors ◽  
Histone Deacetylase ◽  
Nuclear Receptors ◽  
Nuclear Receptor ◽  
Target Genes ◽  
Membrane Receptors ◽  
Special Role ◽  
Multicomponent Complex ◽  
Associated Proteins

Nuclear receptors are ligand-dependent transcription factors which can also be activated in the absence of their lipophilic ligands by signaling substances acting on cell membrane receptors. This ligand-independent activation indicates the importance of nuclear receptor phosphorylation for their function. Nuclear receptor-mediated transcription of target genes is further increased by interactions with recruited coactivators forming a novel family of nuclear proteins. CBP/p300, a coactivator of different classes of transcription factors, including the tumor suppressor protein p53, plays a special role acting as a bridging protein between inducible transcription factors and the basal transcription apparatus, and as an integrator of diverse signaling pathways. Coactivators of nuclear receptors and associated proteins forming a multicomponent complex have an intrinsic histone acetylase activity in contrast to nuclear receptor and heterodimer Mad-Max corepressors, which recruit histone deacetylase. Similarly the Rb protein interacts with histone deacetylase to repress transcription of cell cycle regulatory genes. Targeted histone acetylation/deacetylation results in remodeling of chromatin structure and correlates with activation/repression of transcription. Recent data point to the important role of coactivator proteins associated with inducible transcription factors in transcription regulation, and in the integration of multiple signal transduction pathways within the nucleus.

scholarly journals The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors

FEBS Letters ◽  
2007 ◽  
Vol 581 (19) ◽  
pp. 3616-3625 ◽  
Author(s):  
Sebastian G.B. Furness ◽  
Michael J. Lees ◽  
Murray L. Whitelaw
Keyword(s):  
Transcription Factors ◽  
Aryl Hydrocarbon Receptor ◽  
Adaptive Responses ◽  
Aryl Hydrocarbon

scholarly journals Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells

2016 ◽  
Vol 437 ◽  
pp. 190-200 ◽  
Author(s):  
Ping Gong ◽  
Zeynep Madak-Erdogan ◽  
Jodi A. Flaws ◽  
David J. Shapiro ◽  
John A. Katzenellenbogen ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Aryl Hydrocarbon Receptor ◽  
Estrogen Receptor Α ◽  
Target Cells ◽  
Aryl Hydrocarbon
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