URINARY EXCRETION OF FREE CATECHOLAMINES IN GRAVES' DISEASE

1971 ◽  
Vol 49 (1) ◽  
pp. 167-173 ◽  
Author(s):  
R. I. S. BAYLISS ◽  
O. M. EDWARDS
Keyword(s):  
Urinary Excretion ◽  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Graves Disease ◽  
Apparent Increase ◽  
Catecholamine Excretion ◽  
Sympathetic Nervous ◽  
Noradrenaline And Adrenaline

SUMMARY As judged by the urinary excretion of free noradrenaline and adrenaline, the secretion of catecholamines is not increased in patients with Graves' disease. Catecholamine excretion was not reduced by treatment with propranolol or carbimazole singly or in combination. The possible mechanism in hyperthyroidism responsible for the apparent increase in sympathetic nervous activity and the mitigation of these features by propranolol is discussed.

Variations in Individual Organ Release of Noradrenaline Measured by An Improved Radioenzymatic Technique; Limitations of Peripheral Venous Measurements in the Assessment of Sympathetic Nervous Activity

1981 ◽  
Vol 61 (5) ◽  
pp. 585-590 ◽  
Author(s):  
M. J. Brown ◽  
D. A. Jenner ◽  
D. J. Allison ◽  
C. T. Dollery
Keyword(s):  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Nervous Activity ◽  
Artery Stenosis ◽  
Plasma Noradrenaline ◽  
Sympathetic Nervous Activity ◽  
Release Of Noradrenaline ◽  
Noradrenaline Concentration ◽  
Sympathetic Nervous ◽  
Noradrenaline And Adrenaline

1. The validity of plasma noradrenaline as an index of sympathetic nervous activity was assessed by estimating variation in individual organ contribution to circulating concentrations. 2. Arteriovenous (A—V) differences in noradrenaline and adrenaline concentration were measured across several organs in nine patients with mild essential hypertension, in five with renal artery stenosis and 15 phaeochromocytoma patients. 3. In patients with phaeochromocytomas the percentage extraction of noradrenaline and adrenaline (estimated from the A—V differences) was similar across all organs, suggesting that adrenaline extraction could be used as a marker for noradrenaline extraction. 4. In the non-tumour patients the A—V difference for noradrenaline was less than that for adrenaline across most organs studied, reflecting the net result of noradrenaline release and extraction. The estimated contribution of various organs to the noradrenaline concentrations in their venous effluent was: heart. 21%; kidney 47%; legs 68%. 5. This pattern of A—V difference proved a positive diagnostic feature for non-tumour patients since it was not found even in the patients with small phaeochromocytomas, whose peripheral venous noradrenaline concentration alone did not distinguish them. 6. The venous-arterial difference across the adrenal glands of non-tumour patients was more than 10-fold greater for adrenaline than that for noradrenaline. Since the mean arterial concentration of noradrenaline was more than fivefold higher than that of adrenaline, the normal adrenal contribution to circulating noradrenaline is likely to be less than 2%. 7. In the patients with renal artery stenosis renal venous concentrations of noradrenaline (from the ischaemic kidney) were higher than arterial values, but mean arterial values were no higher than in the essential hypertensive patients. 8. Local variations in sympathetic activity may occur without altering the plasma noradrenaline concentration measured in peripheral plasma.

Sympathetic nervous activity in carriers of MC4R mutations

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
D Heutling ◽  
F Sayk ◽  
C Dodt ◽  
HL Fehm ◽  
A Hinney ◽  
...  
Keyword(s):  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Sympathetic Nervous

Sympathetic nervous activity in patients with chronic renal failure

1994 ◽  
Vol 1 ◽  
pp. 314
Author(s):  
E. Gotoh ◽  
T. Matsukawa ◽  
S. Sumita ◽  
K. Ashino ◽  
N. Takagi ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Sympathetic Nervous

Cerebral metabolism and its relationship with sympathetic nervous activity in essential hypertension

1996 ◽  
Vol 14 (8) ◽  
pp. 951???960 ◽  
Author(s):  
Gavin W. Lambert ◽  
Mario Vaz ◽  
Chakravarthi Rajkumar ◽  
Helen S. Cox ◽  
Andrea G. Turner ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Cerebral Metabolism ◽  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Sympathetic Nervous
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