PERMISSIVE ROLE OF l-THYROXINE IN THE INDUCTION OF STOMACH PEPSINOGEN BY CORTISOL IN NEONATAL RATS

1980 ◽  
Vol 87 (3) ◽  
pp. 431-435 ◽  
Author(s):  
MASAYOSHI KUMEGAWA ◽  
TOSHIHIKO YAJIMA ◽  
NORIHIKO MAEDA ◽  
TAISHIN TAKUMA ◽  
SATOKO HOSODA
Keyword(s):  
Enzyme Activity ◽  
Direct Effect ◽  
Subcutaneous Injection ◽  
Neonatal Rats ◽  
Permissive Role

Subcutaneous injection of cortisol (10 μg/g body wt daily for 5 days) into normal neonatal rats increased the activity of stomach pepsinogen after day 5. l-Thyroxine (T4; 0·2 μg/g body wt daily for 5 days) alone did not affect the activity but it somewhat enhanced the effect of cortisol. Even before day 5, when no effect of cortisol alone was observed, T4 plus cortisol increased pepsinogen activity. In adrenalectomized, thyroidectomized neonatal rats, injection of cortisol alone did not induce enzyme activity but cortisol together with T4 did induce it. Moreover, the increase in pepsinogen activity was depressed in rats thyroidectomized on day 10 but not in those thyroidectomized on day 15. These results suggest that T4 does not have a direct effect on the stomach but plays an important role in making the stomach responsive to glucocorticoids, resulting in increased pepsinogen activity.

PERMISSIVE ROLE OF l-THYROXINE IN INDUCTION OF PANCREATIC AMYLASE BY CORTISOL IN NEONATAL RATS

1980 ◽  
Vol 86 (3) ◽  
pp. 497-500 ◽  
Author(s):  
MASAYOSHI KUMEGAWA ◽  
NORIHIKO MAEDA ◽  
TOSHIHIKO YAJIMA ◽  
TAISHIN TAKUMA ◽  
EIKO IKEDA ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Amylase Activity ◽  
Daily Injection ◽  
Pancreatic Amylase ◽  
Neonatal Rats ◽  
Rat Pancreas ◽  
Developing Rat ◽  
Permissive Role ◽  
Intact Rats

The effect of l-thyroxine (T4) on amylase activity in the developing rat pancreas has been investigated. Administration of T4 (0·2 μg/g body wt) alone to intact rats on days 5–10 after birth did not induce pancreatic amylase but the enzyme was induced significantly by daily injection of cortisol (10 μg/g body wt) alone into intact rats over the same period. In thyroidectomized, adrenalectomized rats pancreatic amylase was not induced by the injection of cortisol alone but it was induced by the administration of cortisol plus T4. Increase in enzyme activity was much less in thyroidectomized animals than in intact animals. These results suggested that T4 does not have a direct effect in increasing pancreatic amylase activity but plays a permissive role in increasing enzyme activity.

Permissive role of neutrophils in pathogenesis of indomethacin-induced gastric lesions in rats

2001 ◽  
Vol 120 (5) ◽  
pp. A595-A595
Author(s):  
M TAKEEDA ◽  
Y KOMOIKE ◽  
S KATO ◽  
H MIMAKI ◽  
K TAKEUCHI
Keyword(s):  
Gastric Lesions ◽  
Permissive Role

The Influence of Competency of Preschool Teachers in Fujian Province on Subjective Well-Being: The Mediating Role of Psychological Capital

2019 ◽  
Author(s):  
Xuguang Sun ◽  
Ailing Huang
Keyword(s):  
Direct Effect ◽  
Psychological Capital ◽  
Preschool Teachers ◽  
Well Being ◽  
Mediating Effect ◽  
Subjective Well Being ◽  
Positive Psychological Capital ◽  
Mediating Role ◽  
Mediator Variable

The intermediary effect interval of the preschool teachers' competence characteristics → positive psychological capital → the subjective well-being of the preschool teachers is (0.23—0.55), does not contain 0, and the effect amount is 0.35. The competency characteristics of preschool teachers → The direct effect interval of subjective well-being of preschool teachers is (0.05—0.36), excluding 0, and the effect quantity is 0.20, indicating that positive psychological capital as a mediator variable has the characteristics of preschool teachers and the subjective well-being of preschool teachers. Partial mediating effect, the ratio of mediating effect to total effect is 64.01%.

Service Quality and Repeat Purchase: The Moderating Effect of Perceived Value, and Satisfaction

2020 ◽  
Vol 11 (1) ◽  
pp. 5-5
Author(s):  
Aprihatiningrum Hidayati ◽  
Agus W. Soehadi ◽  
Aji Hermawan ◽  
Hartoyo Hartoyo
Keyword(s):  
Service Quality ◽  
Direct Effect ◽  
Purchase Intention ◽  
Perceived Value ◽  
Moderating Variables ◽  
Mediating Role ◽  
Prior Literature ◽  
Repeat Purchase ◽  
Purchase Satisfaction

The purpose of this study is to examine the direct and indirect effect of these determinants on repeat purchase. Competitive training industries impose pressure on managers to increase repeat purchase. Even though service quality and repeat purchase are well studied in prior literature, their determinants such as perceived value and satisfaction have not been fully investigated together as moderating variables. Most of literature stated both of perceived value and satisfaction as independent variables. Besides, most of literature consider purchase as an attitudinal (namely purchase intention), while this study focus on behavioural (namely repeat purchase). Data from a survey of 300 customers of public training are used to empirically evaluate the model. Results indicate that perceived value and the satisfaction have no direct effect on repeat purchase. However, these constructs indirectly influence repeat purchase through the mediating role of service quality. Satisfaction and perceived value play a major role in enhancing service quality, but do not directly impact repeat purchase. Interestingly, the direct effect on repeat purchases stems from service quality while recent researches suggest satisfaction is the antecedent. The findings suggest that training companies should invest more resources aimed at enhancing service quality through service delivery training for their employees. Even though prior research has considered the concepts studied here, this study aims to empirically evaluate a variety of antecedent factors that potentially affect repeat purchase. Relationships are established utilizing data collected in Indonesia (an increasingly important consumer market) which adds value to extant knowledge in this area. Keywords: path analysis, perceived value, repeat purchase, satisfaction, service quali

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