scholarly journals Angiotensin I-converting enzyme gene polymorphisms: relationship to nephropathy in patients with non-insulin dependent diabetes mellitus.

1998 ◽  
Vol 9 (9) ◽  
pp. 1664-1669
Author(s):  
W Grzeszczak ◽  
M J Zychma ◽  
B Lacka ◽  
E Zukowska-Szczechowska
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Control Group ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Enzyme Gene ◽  
Angiotensin I Converting Enzyme ◽  
Insulin Dependent

Nephropathy is a frequent complication of long-term diabetes. Strong evidence exists that genetic predisposition plays a major role in the development of diabetic nephropathy. The role of the angiotensin I-converting enzyme gene (ACE) in the susceptibility to nephropathy in diabetes, especially in non-insulin dependent diabetes mellitus (NIDDM), remains unclear. This study examines the association of two ACE polymorphisms: a 287-bp insertion/deletion (I/D) in intron 16 and PstI (A/G substitution in intron 7; alleles P/M) with renal complications in 941 NIDDM patients. From this group, for further analysis 127 patients were selected with overt proteinuria or chronic renal failure, 335 patients with microalbuminuria, and a control group of 254 normoalbuminuric patients with a diabetes duration of at least 10 yr. No significant differences in the distribution of ACE I/D and PstI genotypes or allele frequencies were observed between the examined groups. The results of this study strongly suggest that there is no association between the ACE gene I/D and PstI polymorphisms and nephropathy in NIDDM.

scholarly journals Angiotensin I converting enzyme gene polymorphism in non-insulin dependent diabetes mellitus

1996 ◽  
Vol 50 (2) ◽  
pp. 657-664 ◽  
Author(s):  
Hiroaki Yoshida ◽  
Satoru Kuriyama ◽  
Yoshihito Atsumi ◽  
Haruo Tomonari ◽  
Tetsuya Mitarai ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Enzyme Gene ◽  
Angiotensin I Converting Enzyme ◽  
Insulin Dependent

Distinct Associations of HbA1c and the Urinary Excretion of Pentosidine, an Advanced Glycosylation End-product, with Markers of Endothelial Function in Insulin-dependent Diabetes mellitus

1998 ◽  
Vol 80 (07) ◽  
pp. 52-57 ◽  
Author(s):  
Ronald Smulders ◽  
Casper Schalkwijk ◽  
Ab Donker ◽  
Victor van Hinsbergh ◽  
Johan TeKoppele ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Endothelial Function ◽  
Urinary Excretion ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Control Group ◽  
Advanced Glycosylation End Products ◽  
Insulin Dependent ◽  
Advanced Glycosylation

SummaryDysfunction of the vascular endothelium is considered an early step in the development of diabetic angiopathy. Hyperglycaemia results in endothelial dysfunction, both through direct effects of glucose and through formation of advanced glycosylation end-products (AGEs). We hypothesized that the effects of glucose and AGEs on endothelial function in insulin-dependent diabetes mellitus (IDDM) are distinct and are reflected by distinct plasma markers of endothelial function. We therefore measured plasma levels of von Willebrand factor (vWF), soluble (s) E-selectin and vascular cell adhesion molecule-1 (sVCAM-1), and evaluated the relationship with HbA1c and urinary excretion of pentosidine, an AGE product, in 56 patients with IDDM. Urinary pentosidine excretion was higher in the diabetic than in a control group (n = 60) of similar age (P <0.0001) and showed a steeper increase with age (P <0.02 vs controls). In the diabetic group, sE-selectin was correlated to HbA1c (r = 0.52, P <0.0001), whereas sVCAM-1 was not (r = 0.11, P = 0.47). In contrast, sVCAM-1 showed a trend towards a correlation with log (pentosidine excretion) (r = 0.27, P = 0.06), whereas sE-selectin did not (r = –0.16, P = 0.27). Log(vWF) was correlated to HbA1c (r = 0.50, P <0.0001) and tended to correlate with log (pentosidine excretion) (r = 0.25, P = 0.07). Multivariate analyses with both pentosidine and HbA1c as independent variables showed significant associations of sE-selectin with HbA1c, of sVCAM-1 with pentosidine, and of log(vWF) with both HbA1c and pentosidine (all P-values <0.02). Our results imply that the effects of glucose and AGEs on the endothelium can be reflected by distinct endothelial markers. Plasma sE-selectin may reflect short-term effects of glucose on the endothelium, sVCAM-1 the effects of AGEs, and vWF the combined effect of glucose and AGEs.

Diabetes and Job Performance: An Empirical Investigation

1993 ◽  
Vol 19 (4) ◽  
pp. 293-298
Author(s):  
David S. Greene ◽  
Gary D. Geroy
Keyword(s):  
Diabetes Mellitus ◽  
Job Performance ◽  
Insulin Dependent Diabetes Mellitus ◽  
The United States ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Control Group ◽  
Interpersonal Behaviors ◽  
Insulin Dependent ◽  
Task Behaviors

There are approximately 11 million people in the United States with diabetes, and the numbers are increasing by 6% annually. Still, the relationship between diabetes and job performance remains unclear and marked by bias. To help clarify this relationship, a multicriterion job-performance rating scale was developed to rate task behaviors, interpersonal behaviors, dowr-time behaviors, and hazardous behaviors. A volunteer sample of 53 subjects was selected from people with insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM). All subjects were rated individually by a supervisor; who also rated the norm for the work group. The norm rating was used to determine a norm-referenced control group. The subjects were rated better than the norm in all categories and on all criteria: composite job performance (P<.001), task behaviors (P<.01), interpersonal behaviors (P<.01), down-time behaviors (P<.05), and hazardous behaviors (P<.001).

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