scholarly journals Determination of selected acute phase proteins during the treatment of limb diseases in dairy cows

2008 ◽  
Vol 53 (No. 4) ◽  
pp. 173-183 ◽  
Author(s):  
P. Jawor ◽  
S. Steiner ◽  
T. Stefaniak ◽  
W. Baumgartner ◽  
A. Rzasa
Keyword(s):  
Treatment Group ◽  
Dairy Cows ◽  
Acute Phase ◽  
Serum Amyloid A ◽  
Acute Phase Proteins ◽  
Acute Phase Protein ◽  
Serum Amyloid ◽  
Blood Samples ◽  
Amyloid A ◽  
Phase Protein

The purpose of this study was to assess the diagnostic value of fibrinogen, haptoglobin, and serum amyloid A determination in the monitoring of the treatment of limb diseases in dairy cows. Fourteen lame cows were examined, while 10 clinically healthy cows constituted the control group. Blood samples from the ill animals were collected on three occasions: (1) upon arrival at the clinic, (2) between the third and sixth day after arriving, and (3) upon return to the owner. Blood samples from the control cows were collected once. Plasma levels of fibrinogen, haptoglobin, serum amyloid A, and total serum protein and its fractions (albumin, &alpha;-, &beta;-, &gamma;-globulins) were measured. Significantly higher fibrinogen, haptoglobin, and serum amyloid A levels were observed in the affected cows upon arrival at the clinic than in the control cows. Based on the changes in fibrinogen, haptoglobin, and serum amyloid A concentrations, the cows were divided into those with a systematic decrease in acute-phase protein levels during treatment (Group I, <I>n</I> = 6) and those which showed an increase in one or more acute-phase proteins despite treatment (Group II, <I>n</I> = 8). A stepwise decrease in the examined acute-phase proteins was observed in the first group and indicated an uncomplicated course of treatment; however, treatment of the second group did not appear to be wholly successful. A majority of the cows under treatment (<I>n</I> = 13) exhibited abnormal levels of the examined acute-phase proteins upon return to the owner. This indicates that these patients did not recover completely. The monitoring of plasma acute-phase protein concentrations can be a valuable complement to the clinical assessment of the treatment course and in the early detection of disease complications.

The Acute-Phase Protein Serum Amyloid A Induces G-CSF Expression.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3855-3855
Author(s):  
Rong He ◽  
Jian Zhou ◽  
Richard D. Ye
Keyword(s):  
Acute Phase ◽  
Blood Circulation ◽  
Serum Amyloid A ◽  
Acute Phase Proteins ◽  
Acute Phase Protein ◽  
Inflammatory Diseases ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Phase Protein ◽  
Blood Neutrophils

Abstract Host response to injury and infection is accompanied by a rapid rise of acute-phase proteins in the blood. Serum amyloid A (SAA) is a major acute-phase protein, and has been used as a marker for inflammatory diseases. However, its precise role in inflammation has not been defined. In our previous study, we found that SAA can induce IL-8 and TNF-alpha secretion from peripheral blood neutrophils, which indicates that SAA has cytokine-like functions. We have also identified SAA as an endogenous ligand that induces the expression of interleukin-23 (IL-23), a hetero-dimeric cytokine that promotes autoimmune inflammation. In this study, we reported that SAA stimulates monocytes to secret granulocyte colony-stimulated factor (G-CSF), a cytokine and a major hematopoietic growth factor. Injection of SAA into mouse peritoneum significantly increases the number of neutrophils in both peritoneal cavity and blood circulation. These results suggest that SAA can induce granulocytosis during infection and inflammation. We hypothesize that during the inflammation, locally or systematically produced SAA can increase the number of neutrophils in blood circulation and recruits them to injured or infected sites through induction of G-CSF.

Serum Amyloid A, an Acute Phase Protein, Inhibits Platelet Activation

1991 ◽  
pp. 133-134 ◽  
Author(s):  
Shulamit Zimlichman ◽  
Abraham Danon ◽  
Ilana Nathan ◽  
Gabriel Mozes ◽  
Ruth Shainkin-Kestenbaum
Keyword(s):  
Platelet Activation ◽  
Acute Phase ◽  
Serum Amyloid A ◽  
Acute Phase Protein ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Phase Protein

Acute Phase Protein, Serum Amyloid A, Inhibits IL-1- and TNF-Induced Fever and Hypothalamic PGE2 in Mice

1991 ◽  
Vol 34 (2) ◽  
pp. 179-183 ◽  
Author(s):  
R. SHAINKIN-KESTENBAUM ◽  
G. BERLYNE ◽  
S. ZIMLICHMAN ◽  
H. R. SORIN ◽  
M. NYSKA ◽  
...  
Keyword(s):  
Acute Phase ◽  
Serum Amyloid A ◽  
Acute Phase Protein ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Phase Protein ◽  
Protein Serum

Serum amyloid A (SAA): an acute phase protein and apolipoprotein

1993 ◽  
Vol 102 (2) ◽  
pp. 131-146 ◽  
Author(s):  
Ernst Malle ◽  
Armin Steinmetz ◽  
John G. Raynes
Keyword(s):  
Acute Phase ◽  
Serum Amyloid A ◽  
Acute Phase Protein ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Phase Protein

Acute Phase Protein, Serum Amyloid A, Inhibits IL-1- and Tnf-Induced Fever and Hypothalamic Pge2 in Mice

1991 ◽  
pp. 66-67
Author(s):  
Ruth Shainkin-Kestenbaum ◽  
Geffry Berlyne ◽  
Shulamit Zimlichman ◽  
Abraham Danon
Keyword(s):  
Acute Phase ◽  
Serum Amyloid A ◽  
Acute Phase Protein ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Phase Protein ◽  
Protein Serum

scholarly journals The acute-phase response in (NZB X NZW)F1 and MRL/l MICE.

1982 ◽  
Vol 156 (4) ◽  
pp. 1268-1273 ◽  
Author(s):  
C Rordorf ◽  
H P Schnebli ◽  
M L Baltz ◽  
G A Tennent ◽  
M B Pepys
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Acute Phase Proteins ◽  
Acute Phase Protein ◽  
Phase Response ◽  
Serum Amyloid ◽  
Human Rheumatoid Arthritis ◽  
Amyloid A ◽  
Serum Amyloid A Protein ◽  
Phase Protein

The acute-phase plasma protein response to disease activity in murine models of autoimmune lupus-like disease was investigated by measurement of the concentration of serum amyloid P component (SAP) in NZB X W and MRL/l mice. The levels of SAP, which is a major acute-phase protein in mice, did not rise at all in response to progression of disease in NZB X W mice between the ages of 1 and 9 mo. This resembles the behavior of acute-phase proteins such as C-reactive protein and serum amyloid A protein in human systemic lupus erythematosus, and just as in human lupus, where the occurrence of intercurrent microbial infection can stimulate an acute-phase response, so injection of bacterial lipopolysaccharide or casein into the NZB X W mice stimulated "normal" acute-phase SAP production. In marked contrast, MRL/l mice developed greatly increased levels of SAP, which correlated closely with progression of their pathology as they aged. The disease profile of the MRL/l strain includes rheumatoid factors and spontaneous polyarthritis and their SAP response resembles the behavior of acute phase proteins in human rheumatoid arthritis. Different patterns of acute-phase response in different autoimmune disorders may thus be a reflection of the genetic predisposition to particular diseases and/or contribute to their pathogenesis. The existence of animal counterparts for the various clinical patterns of human acute-phase protein production will assist in experimental investigation of the underlying mechanisms and of the biological role of the acute-phase response.

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