Ultrasound Measurement of Peripheral Endothelial Dysfunction in Type 2 Diabetic Patients: Correlation with Risk Factors

The purpose of the study was to assess the endothelial dysfunction (ED) in type 2 diabetic patients ultrasonographically and estimate the correlation of ED with glycemia and other cardio-metabolic risk factors. 171 patient (age 60.0 + 8.5 years) with diagnosed type 2 diabetes and coronary artery disease (CAD) were randomly included in a cross sectional study. B-mode ultrasound system with a linear transducer of 7.5 MHz was used for evaluation of flow-mediated vasodilation in brachial artery (FMV). FMV was presented as a change of brachial artery diameter at rest and after limb ischemia, previously provoked by cuff inflation. Peripheral ED was found in 77.2% (132 patients). Multivariate logistic regression model defined: age (OR 1.071, 95% CI 1.003 1,143) and plasma cholesterol (OR 4.083 95% CI 1.080 17,017) as determinants for ED. Linear multivariate analysis presented duration of diabetes (Beta 0.173, Sig 0.024), and glycemia (Beta 0.132, Sig 0.044) to be associated independently with FMV value. Estimated factors influencing FMV, might be potential therapeutic targets for presented endothelial dysfunction in type 2 diabetic patients with coronary artery disease.

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Association of classical risk factors and coronary artery disease in type 2 diabetic patients submitted to coronary angiography

Diabetology & Metabolic Syndrome ◽

10.1186/1758-5996-6-46 ◽

2014 ◽

Vol 6 (1) ◽

pp. 46 ◽

Cited By ~ 10

Author(s):

Célia Bittencourt ◽

Valdecira M Piveta ◽

Carolina SV Oliveira ◽

Felipe Crispim ◽

Deyse Meira ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Coronary Angiography ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Artery Disease ◽

Type 2 Diabetic

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ENDOTHELIAL DYSFUNCTION CORRELATES WITH PLASMA FIBRINOGEN AND HDL CHOLESTEROL IN TYPE 2 DIABETIC PATIENTS WITH CORONARY ARTERY DISEASE

Journal of Thrombosis and Haemostasis ◽

10.1111/j.1538-7836.2007.tb00734.x ◽

2007 ◽

Vol 5 ◽

pp. P-S-639-P-S-639 ◽

Cited By ~ 1

Author(s):

M. Bosevski ◽

V. Borozanov ◽

M. Vavlukis ◽

I. Peovska ◽

L. Georgievska-Ismail

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Endothelial Dysfunction ◽

Hdl Cholesterol ◽

Plasma Fibrinogen ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Artery Disease ◽

Type 2 Diabetic

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Abstract: P1183 MIGLITOL IMPROVES POSTPRANDIAL HYPERGLYCEMIA, HYPERINSULINEMIA AND ENDOTHELIAL DYSFUNCTION IN TYPE 2 DIABETIC PATIENTS WITH CORONARY ARTERY DISEASE

Atherosclerosis Supplements ◽

10.1016/s1567-5688(09)71210-3 ◽

2009 ◽

Vol 10 (2) ◽

pp. e1247

Author(s):

M Hiki ◽

K Shimada ◽

T Kiyanagi ◽

T Kurata ◽

A Kume ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Endothelial Dysfunction ◽

Postprandial Hyperglycemia ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Artery Disease ◽

Type 2 Diabetic

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Is assessment of peripheral endothelial dysfunction useful tool for risk stratification of type 2 diabetic patients with manifested coronary artery disease?

International Journal of Cardiology ◽

10.1016/j.ijcard.2007.08.011 ◽

2009 ◽

Vol 131 (2) ◽

pp. 290-292 ◽

Cited By ~ 1

Author(s):

M. Bosevski ◽

V. Borozanov ◽

S. Tosev ◽

Lj. Georgievska-Ismail

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Endothelial Dysfunction ◽

Risk Stratification ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Artery Disease ◽

Type 2 Diabetic

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Evaluation of aortic arch calcification in type 2 diabetic patients

VASA ◽

10.1024/0301-1526.34.2.113 ◽

2005 ◽

Vol 34 (2) ◽

pp. 113-117 ◽

Cited By ~ 4

Author(s):

Papanas ◽

Symeonidis ◽

Maltezos ◽

Giannakis ◽

Mavridis ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Aortic Arch ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Insulin Dependence ◽

Artery Disease ◽

Type 2 Diabetic ◽

Aortic Arch Calcification

Background: The purpose of this study is to evaluate the severity of aortic arch calcification among type 2 diabetic patients in association with diabetes duration, diabetic complications, coronary artery disease and presence of cardiovascular risk factors. Patients and methods: This study included 207 type 2 diabetic patients (101 men) with a mean age of 61.5 ± 8.1 years and a mean diabetes duration of 13.9 ± 6.4 years. Aortic arch calcification was assessed by means of posteroanterior chest X-rays. Severity of calcification was graded as follows: grade 0 (no visible calcification), grade 1 (small spots of calcification or single thin calcification of the aortic knob), grade 2 (one or more areas of thick calcification), grade 3 (circular calcification of the aortic knob). Results: Severity of calcification was grade 0 in 84 patients (40.58%), grade 1 in 64 patients (30.92%), grade 2 in 43 patients (20.77%) and grade 3 in 16 patients (7.73%). In simple regression analysis severity of aortic arch calcification was associated with age (p = 0.032), duration of diabetes (p = 0.026), insulin dependence (p = 0.042) and presence of coronary artery disease (p = 0.039), hypertension (p = 0.019), dyslipidaemia (p = 0.029), retinopathy (p = 0.012) and microalbuminuria (p = 0.01). In multiple regression analysis severity of aortic arch calcification was associated with age (p = 0.04), duration of diabetes (p = 0.032) and presence of hypertension (p = 0.024), dyslipidaemia (p = 0.031) and coronary artery disease (p = 0.04), while the association with retinopathy, microalbuminuria and insulin dependence was no longer significant. Conclusions: Severity of aortic arch calcification is associated with age, diabetes duration, diabetic complications (retinopathy, microalbuminuria), coronary artery disease, insulin dependence, and presence of hypertension and dyslipidaemia.

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