scholarly journals Synthesis of starch-g-poly (acrylic acid-co-2-hydroxy ethyl methacrylate) as potential pH-sensitive hydrogelbased drug delivery system

2011 ◽  
Vol 4 (9) ◽  
pp. 1090-1095 ◽  
Author(s):  
Mohammad Sadeghi
Keyword(s):  
Drug Delivery ◽  
Acrylic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Ethyl Methacrylate ◽  
Poly Acrylic Acid

pH-responsive drug delivery system based on luminescent CaF2:Ce3+/Tb3+-poly(acrylic acid) hybrid microspheres

Biomaterials ◽  
2012 ◽  
Vol 33 (8) ◽  
pp. 2583-2592 ◽  
Author(s):  
Yunlu Dai ◽  
Cuimiao Zhang ◽  
Ziyong Cheng ◽  
Ping’an Ma ◽  
Chunxia Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Acrylic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Responsive ◽  
Poly Acrylic Acid

scholarly journals Preparation and Characterization of Ionic Conductive Poly(acrylic Acid)-Based Silicone Hydrogels for Smart Drug Delivery System

Polymers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 406
Author(s):  
Young-Ah Kim ◽  
Jin-Oh Jeong ◽  
Jong-Seok Park
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Acrylic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cell Compatibility ◽  
Silicone Hydrogel ◽  
Smart Drug ◽  
Smart Drug Delivery ◽  
Poly Acrylic Acid

In this study, we developed a smart drug delivery system that can efficiently deliver the required amounts of drugs using the excellent ion conductivity of poly(acrylic acid) (PAA) and an electrical stimulus. As a result of its having carboxyl groups, PAA hydrogel can be used in drug delivery patches to release drugs by ionic conductivity. However, PAA hydrogel has low durability and poor mechanical properties. The carboxyl group of PAA was combined with a siloxane group of silicone using electron-beam irradiation to easily form a crosslinked structure. The PAA–silicone hydrogel has excellent mechanical properties. Specifically, the tensile strength increased more than 3.5 times. In addition, we observed its cell compatibility using fluorescence staining and CCK-8 assays and found good cell viability. Finally, it was possible to control the drug delivery rate efficiently using the voltage applied to the ion-conductive hydrogel. As the voltage was increased to 3, 5, and 7 V, the amount of drug released was 53, 88, and 96%, respectively. These excellent properties of the PAA–silicone hydrogel can be used not only for whitening or anti-wrinkling cosmetics but also in medical drug-delivery systems.

Thermosensitive Poloxamer 407/Poly(Acrylic Acid) Hydrogels with Potential Application as Injectable Drug Delivery System

2018 ◽  
Vol 19 (5) ◽  
pp. 2103-2117 ◽  
Author(s):  
Wannisa Boonlai ◽  
Vimon Tantishaiyakul ◽  
Namon Hirun ◽  
Tanatchaporn Sangfai ◽  
Krit Suknuntha
Keyword(s):  
Drug Delivery ◽  
Acrylic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Potential Application ◽  
Poloxamer 407 ◽  
Injectable Drug ◽  
Poly Acrylic Acid

scholarly journals In vitro evaluation of a novel pH sensitive drug delivery system based cockle shell-derived aragonite nanoparticles against osteosarcoma

2017 ◽  
Vol 12 (1) ◽  
pp. 166-187 ◽  
Author(s):  
Wenliang Fu ◽  
Mohd Hezmee Mohd Noor ◽  
Loqman Mohamad Yusof ◽  
Tengku Azmi Tengku Ibrahim ◽  
Yeap Swee Keong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
In Vitro Evaluation ◽  
Cockle Shell
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