scholarly journals Developing Hemophagocytic Syndrome during the transformation of Chronic Lymphocytic Leukemia: Case reports of t(7;14), t(14;19) and deletion of 17 p

2018 ◽  
Vol 5 (5) ◽  
pp. 188-191
Author(s):  
Tarik Onur Tiryaki ◽  
Sezen Genc ◽  
Gulcin Bagatir Ozan ◽  
Kivanc Cefle ◽  
Sukru Palanduz ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Hemophagocytic Syndrome ◽  
Case Reports ◽  
Lymphocytic Leukemia ◽  
Chronic Lymphocytic Leukemia Case

scholarly journals Chronic Lymphocytic Leukemia in Blood Relatives: Two Case Reports of Male Siblings

2021 ◽  
Vol 14 (1) ◽  
pp. 69-72
Author(s):  
Nadezhda Viktorovna Kurkina ◽  
E.A. Repina
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Case Reports ◽  
Lymphocytic Leukemia

T4 + (helper phenotype) chronic lymphocytic leukemia: Case report with liver failure and literature review

1988 ◽  
Vol 16 (5) ◽  
pp. 356-362 ◽  
Author(s):  
John P. Greer ◽  
John B. Cousar ◽  
Robert F. Miller ◽  
Larry B. Vogler ◽  
Julia C. Goodin ◽  
...  
Keyword(s):  
Case Report ◽  
Chronic Lymphocytic Leukemia ◽  
Literature Review ◽  
Liver Failure ◽  
Lymphocytic Leukemia ◽  
Chronic Lymphocytic Leukemia Case

scholarly journals Chronic Lymphocytic Leukemia Presenting as a Subcortical Watershed Infarct

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Mridul Gupta ◽  
Divita Singh ◽  
Patrick Lee ◽  
Sandhya Kadiyam
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Hemolytic Anemia ◽  
Immune Thrombocytopenia ◽  
Case Reports ◽  
Pure Red Cell Aplasia ◽  
Lymphocytic Leukemia ◽  
Red Cell ◽  
Cerebral Infarcts ◽  
Autoimmune Cytopenia ◽  
Watershed Infarcts

Internal watershed infarcts (WI) involve white matter between deep and superficial arterial systems of middle cerebral artery. These infarcts are considered to be either from low blood flow or microembolism. Anemia is an extremely rare cause of watershed infarcts. Very few cases of hemolytic anemia causing watershed cerebral infarcts have been reported. Chronic lymphocytic leukemia (CLL) is frequently complicated with secondary autoimmune cytopenia such as autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), and pure red cell aplasia. AIHA is present in about 7–10% of patients with CLL. AIHA from CLL presenting as WI is an extremely rare phenomenon with no previously published case reports to the best of our knowledge.

Ulcerative balanoposthitis of the foreskin as a manifestation of chronic lymphocytic leukemia: case report and review of the literature

Urology ◽  
2000 ◽  
Vol 56 (4) ◽  
pp. 669 ◽  
Author(s):  
Cara Gatto-Weis ◽  
David Topolsky ◽  
Bruce Sloane ◽  
J.Steve Hou ◽  
Hong Qu ◽  
...  
Keyword(s):  
Case Report ◽  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Review Of The Literature ◽  
Chronic Lymphocytic Leukemia Case

Hemophagocytic Syndrome Associated with CD8 Positive T-cell Chronic Lymphocytic Leukemia

2004 ◽  
Vol 45 (1) ◽  
pp. 193-198 ◽  
Author(s):  
KEIKO ANDO ◽  
KEISUKE MIYAZAWA ◽  
YUZURU KURIYAMA ◽  
YUKIHIKO KIMURA ◽  
KIYOSHI MUKAI ◽  
...  
Keyword(s):  
T Cell ◽  
Chronic Lymphocytic Leukemia ◽  
Hemophagocytic Syndrome ◽  
Lymphocytic Leukemia ◽  
Cell Chronic Lymphocytic Leukemia

scholarly journals Synchronous diagnosis and treatment of acute myeloid leukemia and chronic lymphocytic leukemia: Two case reports

2021 ◽  
Vol 9 (30) ◽  
pp. 9144-9150
Author(s):  
Rong-Rong Chen ◽  
Li-Xia Zhu ◽  
Lu-Lu Wang ◽  
Xue-Ying Li ◽  
Jia-Nai Sun ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Chronic Lymphocytic Leukemia ◽  
Myeloid Leukemia ◽  
Case Reports ◽  
Lymphocytic Leukemia ◽  
Diagnosis And Treatment ◽  
Acute Myeloid

Autoimmune Cytopenias in Patients with Chronic Lymphocytic Leukemia Treated with Cladribine

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 4179-4179
Author(s):  
Jerzy Z Blonski ◽  
Tadeusz Robak ◽  
Jacek Trelinski ◽  
Krzysztof Chojnowski ◽  
Krzysztof Warzocha ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Case Reports ◽  
Lymphocytic Leukemia ◽  
P Value ◽  
Indirect Bilirubin ◽  
Cytotoxic Treatment ◽  
Trial Protocols ◽  
Autoimmune Cytopenias ◽  
Adult Leukemia ◽  
Positive Direct

Abstract Autoimmune disorders like immune haemolytic anemia (AIHA) and immune thrombocytopenia (IT) represent the autoimmune haematological conditions most frequently associated with chronic lymphocytic leukemia (CLL). Recently there has been several case reports suggesting relation between occurrence of these disorders and treatment with purin analogues. The aim of this study was to compare the frequency and prognostic value of AIHA and IT in the group of CLL patients treated with chlorambucil or cladribine. Retrospective analysis of 777 patients treated in 1999–2004 years according to two randomized clinical trial protocols coordinated by Polish Adult Leukemia Group (PALG) was performed. In 104 patients chlorambucil and in 673 cladribine was applied according to NCIWG criteria. In the cladribine group 315 were given monotherapy, in 170 combination therapy with cyclophosphamide (CC) and in 188 with cyclophosphamide and mitoxantron (CMC) were used. The details of the treatment schedules were published previously. IT patients had to fulfill the following diagnostic criteria: rapid and severe fall of the platelet count, normal or augmented number of megakariocytes in bone marrow, no reaction to platelet transfusions, no palpable splenomegaly and no chemotherapy in the last 30 days. No patient had IT before enrolment to any cytotoxic treatment. Diagnosis of AIHA was based on haemoglobin <100 g/l and a positive direct antiglobulin test (DAT) for either immunoglobulin or the complement fragment C3d in the absence of bleeding. For patients with negative DAT the diagnosis was based additionally on the presence of at least two indicators of haemolysis (increased indirect bilirubin, increased reticulocyte count, increased LDH concentration, low haptoglobin concentration). The occurrence of studied events was estimated among end of first and beginning of second line treatment. The results of the study are shown in Table 1. In conclusion the application of cladribine either in monotherapy or in combination with cyclophosphamide or mitoxantron did not significantly increase the frequency of AIHA and/or IT in the studied population in comparison to chlorambucil. Although the remission rates (CR-complete and OR-overall) in patients with concomitant AIHA and IT treated with cladribine was lower than in patients without these complications no influence on and overall survival (OS) was observed. Table.1. Characteristic Cladribine Chlorambucil p value AIHA Yes No Yes No Total (%) 48 (7.1) 625 (92.9) 6 (5.8) 98 (94.2) 0.61 OR (%) 35 72.9 448 80.9 2 33.3 57 58.8 0.11 vs 0.22 CR (%) 10 20.8 194 35.0 0 0.0 12 12.4 0.008 vs 0.36 Death (%) 29 60.4 342 55.1 6 100.0 69 71.1 - OS (median. years) 4.226 3.247 4.843 2.614 0.16 vs 0.81 IT Yes No Yes No Total (%) 50 7.4 623 92.6 5 4.8 99 95.2 0.33 OR (%) 31 63.3 449 81.6 2 40.0 57 58.2 0.004 vs 0.42 CR (%) 5 10.2 196 35.6 1 20.0 11 11.2 0.0006 vs 0.55 Death (%) 36 72.0 335 54.1 5 100.0 70 71.4 - OS (median. years) 2.231 9.595 4.300 5.237 0.11 vs 0.23

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