scholarly journals Analysis of acquisition and the monthly cost of antihypertensive therapy with modern fixed-dose combinations in the Far Eastern Federal District

2021 ◽  
Vol 14 (1) ◽  
pp. 41-49
Author(s):  
M. S. Soboleva ◽  
E. E. Loskutova
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Antihypertensive Drugs ◽  
Group Analysis ◽  
Federal District ◽  
Fixed Dose ◽  
Channel Blockers ◽  
Converting Enzyme Inhibitors ◽  
Monthly Cost ◽  
Far Eastern

Objective: analyzing the acquisition and monthly costs for patients on modern fixed-dose antihypertensive combinations in three regions of the Far Eastern Federal District.Material and methods. Intra-group analysis of retail of antihypertensive drugs for 2019 in drugstores of the Khabarovsk Region, Sakhalin Region, Amur Region (n=100) was carried out. The calculation of the monthly cost of therapy was performed and total sales indicators were identified. Statistical analysis: dispersion analysis, Spearman's rank correlation coefficient, Kruskal–Wallis test.Results. The maximum demand in patients among combinations of -blockers in the price range of 100-500 rubles: atenolol+chlortalidone; bisoprolol+amlodipine. In the grope of combinations of angiotensin-converting enzyme inhibitors with diuretics/calcium channel blockers, the most often acquired were: perindopril/ramipril+indapamide/amlodipine, enalapril+hydrochlorothiazide – in the price segment of 500–1000 rubles. Preferences for the use of combinations of angiotensin II receptor blockers+diuretic/calcium channel blockers: valsartan+amlodipine with a monthly cost of therapy of 300–500 rubles; losartan+hydrochlorothiazide – 100–500 rubles and azilsartan+chlortalidonee – 500–1000 rubles. The most popular three-component drugs were valsartan+amlodipine+hydrochlorothiazide, perindopril+amlodipine+indapamide with a monthly cost over 500 rubles. Differences in the acquisition structure of fixed-dose antihypertensive combinations between regions were statistically significant.Conclusion. The share of sales of combined antihypertensive drugs remains insignificant. The main selection criteria within an international nonproprietary name are affordability or trust in a brand. The presence of a reliable correlation of the acquisition structure with the region proves the influence of regional preferences of specialists in drug prescribing.

scholarly journals Dynamics of the sales of fixed-doses antihypertensive combinations in the southern regions of the far Eastern federal district

2018 ◽  
Vol 24 (4) ◽  
pp. 469-477
Author(s):  
M. S. Soboleva ◽  
E. E. Loskutova
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Enzyme Inhibitors ◽  
Federal District ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Channel Blockers ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors ◽  
Far Eastern

Background. Advantages of the two-component drugs are well-known and described in the professional standards and guidelines. However, in clinical practice their application is often limited, despite the increase in the variants of full-doses combinations.Objective. To analyze the dynamics of sales of the fixed-doses antihypertensive combinations in regions of the Far Eastern federal district.Design and methods. We present the results of the pharmacoepidemiological study of the regional pharmaceutical market of the antihypertensive fixeddoses combinations in Khabarovskii, Primorskii region and the Sakhalin region in 2015–2017.Results. In the studied regions of the Russian Federation, combinations of angiotensin-converting-enzyme inhibitors and diuretics are the most popular. Leading ones appeared to be enalapril + hydrochlorothiazide and perindopril + indapamide. Combinations of angiotensin-converting-enzyme inhibitors with dihydropyridine derivatives calcium channel blockers were acquired seldom. The most popular combinations were perindopril + amlodipine and lizinopril + amlodipine. Among combinations of angiotensin II antagonists with diuretics losartan + hydrochlorothiazide and valsartan + hydrochlorothiazide showed the greatest sales. Combinations including sartan and calcium channel blockers were acquired more seldom, despite the wide range of international non-proprietary variants in drugstores. Atenolol + chlortalidone was in the most popular demand among combinations of β-blockers with diuretics. In 2016 three-component combinations were presented by only four trade names, and their demand is still limited. Nevertheless, a nonsignificant growth of purchases was observed.Conclusions. Our data show low demand of fixed-doses combinations. In regions, as a rule, there is an increase in sales of generic more affordable combinations which proves the significance of both antihypertensive efficiency and the price.

Cardiotoxicity with antihypertensive drugs (literature review) Part 1. Calcium channel blockers and beta-blockers

2021 ◽  
pp. 12-19
Author(s):  
A. N. Esaulenko ◽  
A. Yu. Moiseeva ◽  
A. A. Ivannikov ◽  
I. V. Bratischev ◽  
Kh. G. Alidzhanova
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Antihypertensive Drugs ◽  
Beta Blockers ◽  
Research Literature ◽  
Channel Blockers ◽  
Distinctive Features ◽  
Experimental Pharmacology ◽  
Myocardial Insufficiency ◽  
Β Blockers

The effect of hypotensive drugs overdose on cardiovascular system is poorly studied; it should undergo clinical, experimental pharmacology and toxicology together with cardiology. There is too little information about cardiotoxicity of beta-blockers (β-blockers) and calcium channel blockers (CCB) in existing research literature. Intoxication from these groups of drugs causes similar severe hemodynamic abnormalities and myocardial insufficiency, however pathophysiological mechanisms of these abnormalities are not thoroughly studied. The review highlights how difficult it is to identify toxic level and distinctive features of clinical evidence of intoxication. Methods of diagnosis as well as β-blockers and CCB overdose treatment are discussed.

scholarly journals DRUG UTILIZATION BASED ADRS MONITORING OF ANTIHYPERTENSIVE AGENTS PRESCRIBED IN AL-QUWAYIYAH GENERAL HOSPITAL, SAUDI ARABIA

2018 ◽  
Vol 10 (3) ◽  
pp. 22
Author(s):  
Md Salahuddin Ansari ◽  
Faisal Al-otaibi
Keyword(s):  
Saudi Arabia ◽  
Calcium Channel ◽  
General Hospital ◽  
Drug Utilization ◽  
Calcium Channel Blockers ◽  
Antihypertensive Drugs ◽  
Antihypertensive Agents ◽  
Channel Blockers ◽  
Hypertensive Patients ◽  
Patient Interviews

Objective: To monitor drug utilization based adverse drug reactions (ADRs) of antihypertensive agents prescribed in Al-Quwayiyah general hospital, Saudi Arabia.Methods: An open, non-comparative, observational study was conducted on hypertensive patients attending the medicine outpatient department of Al-Quwayyah general hospital, Al-Quwayyah, Saudi arabia. Data were collected by conducting patient interviews. Data were captured for adverse drug reaction monitoring based on Narinjo scale and WHO format.Results: 25 ADRs were observed out of 212 hypertensive patients. Incidence was found to be higher in patients more than 40 y age, and females experienced more ADRs (n = 16, 7.54%) than males, 9 (4.62%). Combination therapy was associated with more number of ADRs (64.0%) as against monotherapy (36.0%). Calcium channel blockers were found to be the most frequently associated drugs with ADRs (n = 8), followed by diuretics (n = 6), and β-blockers (n = 5). Among individual drugs, amlodipine was found to be the commonest drug associated with ADRs (n = 8), followed by torasemide (n = 4). ADRs associated with the central nervous system was found to be the most frequent (48.0%) followed by musculoskeletal complaints (20.0%) and respiratory system disorders (16.0%).Conclusion: ADRs were experienced by taking the antihypertensive drugs prescribed in Al-Quwayyah general hospital, Saudi arabia. The findings would be useful for physicians in rational prescribing. Calcium channel blockers were found to be the most frequently associated drugs with ADRs.

scholarly journals The safety of antihypertensive drugs. Retrospective analysis of adverse reactions based on a regional database

2021 ◽  
Vol 27 (2) ◽  
pp. 216-228
Author(s):  
A. V. Matveev ◽  
A. E. Krasheninnikov ◽  
A. V. Ushakov ◽  
E. A. Egorova ◽  
A. G. Dormidor
Keyword(s):  
Calcium Channel ◽  
Retrospective Analysis ◽  
Calcium Channel Blockers ◽  
Adverse Reactions ◽  
Antihypertensive Drugs ◽  
Channel Blockers ◽  
Drug Reactions ◽  
Life Threatening ◽  
Β Blockers ◽  
Design And Methods

Objective. To analyze adverse drug reactions (ADR) occuring in patients taking antihypertensive drugs (AHD).Design and methods. We have analyzed 459 cases of ADR caused by AHD and recorded in the regional database (register) called ARCADe (Adverse Reactions in Crimea, Autonomic Database) during 2011–2018 years.Results. Out of all ADR, 304 cases (3,9 4,4 4,9 % of the total number of cases) were associated with AHD affecting renin-angiotensin-aldosterone system,101 (1,2 1,5 1,8 %) — with calcium channel blockers, and 54 cases (0,6 0,8 1,0 %) — with β-blockers. In the majority of cases, the ADRs were attributed to Enalapril (85 cases) and Amlodipine (76 cases). The analysis of the outcomes showed that serious reactions (life-threatening conditions, hospitalization, and disability) occurred in 72 cases. The remaining 387 ADRs were not considered serious. The majority of reported ADRs were unavoidable reactions of mild severity.

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