ADVANTAGES OF BROAD SPECTRUM ANTIEPILEPTIC DRUGS IN TREATMENT OF EPILEPSY

: Epilepsy is a chronic brain disorder caused by abnormal firing of neurons. Up to now, using antiepileptic drugs is the main method of epilepsy treatment. The development of antiepileptic drugs lasted for centuries. In general, most agents entering clinical practice act on the balance mechanisms of brain “excitability-inhibition”. More specifically, they target voltage-gated ion channels, GABAergic transmission and glutamatergic transmission. In recent years, some novel drugs representing new mechanisms of action have been discovered. Although there are about 30 available drugs in the market, it is still in urgent need of discovering more effective and safer drugs. The development of new antiepileptic drugs is into a new era: from serendipitous discovery to evolutionary mechanism-based design. This article presents an overview of drug treatment of epilepsy, including a series of traditional and novel drugs.

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Treatment of Epilepsy Associated with Common Chromosomal Developmental Diseases

Open Life Sciences ◽

10.1515/biol-2020-0003 ◽

2020 ◽

Vol 15 (1) ◽

pp. 21-29

Author(s):

Magdalena Budisteanu ◽

Claudia Jurca ◽

Sorina Mihaela Papuc ◽

Ina Focsa ◽

Dan Riga ◽

...

Keyword(s):

Side Effects ◽

Antiepileptic Drugs ◽

Epileptic Seizures ◽

Specific Response ◽

Genetic Etiology ◽

Antiepileptic Treatment ◽

Treatment Of Epilepsy ◽

Complex Phenotypes ◽

Chromosomal Diseases

AbstractChromosomal diseases are heterogeneous conditions with complex phenotypes, which include also epileptic seizures. Each chromosomal syndrome has a range of specific characteristics regarding the type of seizures, EEG findings and specific response to antiepileptic drugs, significant in the context of the respective genetic etiology. Therefore, it is very important to know these particularities, in order to avoid an exacerbation of seizures or some side effects. In this paper we will present a review of the epileptic seizures and antiepileptic treatment in some of the most common chromosomal syndromes.

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Antiepileptic Drugs in the 21st Century

CNS Spectrums ◽

10.1017/s1092852900001504 ◽

2001 ◽

Vol 6 (9) ◽

pp. 756-765 ◽

Cited By ~ 7

Author(s):

Carl W. Bazil

Keyword(s):

Adverse Effect ◽

Drug Interactions ◽

Antiepileptic Drugs ◽

21St Century ◽

Pharmacokinetic Profile ◽

New Agents ◽

Dosing Schedule ◽

The Past ◽

Treatment Of Epilepsy ◽

Sheer Number

ABSTRACTDuring the past 10 years, there has been a welcome influx of novel agents for the treatment of epilepsy. Many show advantages compared to older agents, including better adverse effect profiles and lack of drug-drug interactions. The sheer number of agents now available makes distinction among them confusing at times. Agents differ in spectrum of action, pharmacokinetic profile (affecting dosing schedule and drug interactions), and titration time. This review highlights the differences between the various new agents and the more traditional antiseizure drugs. Evidence for the widespread use of these compounds outside their indication, particularly for diseases other than epilepsy, is reviewed as well.

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