scholarly journals Treatment of Epilepsy Associated with Common Chromosomal Developmental Diseases

2020 ◽  
Vol 15 (1) ◽  
pp. 21-29
Author(s):  
Magdalena Budisteanu ◽  
Claudia Jurca ◽  
Sorina Mihaela Papuc ◽  
Ina Focsa ◽  
Dan Riga ◽  
...  
Keyword(s):  
Side Effects ◽  
Antiepileptic Drugs ◽  
Epileptic Seizures ◽  
Specific Response ◽  
Genetic Etiology ◽  
Antiepileptic Treatment ◽  
Treatment Of Epilepsy ◽  
Complex Phenotypes ◽  
Chromosomal Diseases

AbstractChromosomal diseases are heterogeneous conditions with complex phenotypes, which include also epileptic seizures. Each chromosomal syndrome has a range of specific characteristics regarding the type of seizures, EEG findings and specific response to antiepileptic drugs, significant in the context of the respective genetic etiology. Therefore, it is very important to know these particularities, in order to avoid an exacerbation of seizures or some side effects. In this paper we will present a review of the epileptic seizures and antiepileptic treatment in some of the most common chromosomal syndromes.

scholarly journals Cognitive and Psychological Side Effects of Antiepileptic Drugs

2020 ◽  
Author(s):  
Katja Eva Brückner
Keyword(s):  
Side Effects ◽  
Medical Treatment ◽  
Antiepileptic Drugs ◽  
Severe Side Effect ◽  
Side Effect Profile ◽  
Profound Impact ◽  
Treatment Of Epilepsy ◽  
In The Beginning ◽  
And Behavior

Among well-known side effects such as dizziness, nausea, headache and diplopia medical treatment of epilepsy may cause side effects on cognition, mood and behavior. In special constellations this can profoundly affect compliance with the medication as well as quality of life. Some patients are more vulnerable to side effects than others. Side effects can have profound impact on the development and future life of a patient. Some antiepileptic drugs (e.g. topiramate, zonisamide) show a more severe side effect profile than others (e.g. lamotrigine, levetiracetam). Thus, in the treatment of epilepsy, it is crucial to consider such possible side effects – especially in the beginning of or while changing the medical treatment. Specific neuropsychological examinations can monitor side effects on cognitive functions like concentration, memory or speech function. If this is not possible in an ambulant setting, specific screening instruments and repeated and precise interviews of patients and/or relatives can help to discover potential side effects. Because most side effects can be reversible, dosage modification or drug replacement is required as soon as incompatibilities are discovered.

scholarly journals Recent advancements to enhance the therapeutic efficacy of antiepileptic drugs

2021 ◽  
Vol 71 (4) ◽  
pp. 527-544
Author(s):  
Fuquan Li ◽  
Akhilesh Vikram Singh
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Antiepileptic Drugs ◽  
The Novel ◽  
Antiepileptic Treatment ◽  
The Past ◽  
Treatment Of Epilepsy ◽  
New Antiepileptic Drugs ◽  
Common Problems ◽  
Novel Drug

Abstract Epilepsy is a multifactorial neurological disorder characterized by recurrent or unprovoked seizures. Over the past two decades, many new antiepileptic drugs (AEDs) were developed and are in use for the treatment of epilepsy. However, drug resistance, drug-drug interaction and adverse events are common problems associated with AEDs. Antiepileptic drugs must be used only if the ratio of efficacy, safety, and tolerability of treatment are favorable and outweigh the disadvantages including treatment costs. The application of novel drug delivery techniques could enhance the efficacy and reduce the toxicity of AEDs. These novel techniques aim to deliver an optimal concentration of the drug more specifically to the seizure focus or foci in the CNS without numerous side-effects. The purpose of this article is to review the recent advancements in antiepileptic treatment and summarize the novel modalities in the route of administration and drug delivery, including gene therapy, for effective treatment of epilepsy.

Place of Newer Antiepileptic Drugs in the Treatment of Epilepsy

Drugs ◽  
1993 ◽  
Vol 46 (6) ◽  
pp. 1009-1024 ◽  
Author(s):  
Reetta Kälviäinen ◽  
Tapani Keränen ◽  
Paavo J. Riekkinen
Keyword(s):  
Antiepileptic Drugs ◽  
Treatment Of Epilepsy

Pregnancy in women with epilepsy

2017 ◽  
pp. 61-64
Author(s):  
Shahla Yagub Melikova ◽  
Keyword(s):  
Key Words ◽  
Antiepileptic Drugs ◽  
Congenital Malformations ◽  
Social Problems ◽  
Neurological Diseases ◽  
Epileptic Seizures ◽  
Conclusive Evidence ◽  
High Dose ◽  
Key Words Pregnancy

Epilepsy is one of the most common serious neurological diseases. Many publications relating to interaction of epilepsy and pregnancy have been studied. Women with epilepsy experience a number of physical and social problems associated with obstetric risk, the risk of seizures during pregnancy. Generalized epileptic seizures may have a direct damaging effect on the fetus, although there is no conclusive evidence for a significant increase in the incidence of complications during pregnancy in women with epilepsy. Antenatal exposure to antiepileptic drugs, especially in high-dose and polytherapy, increases the risk of congenital malformations. There are concerns regarding the effects of antiepileptic drugs on infants during breastfeeding. However, the risk of complications associated with the epilepsy and the effects of antiepileptic drugs on the fetus may be reduced by joint monitor by neurologist-epileptologist and obstetrician. Key words: pregnancy, antiepileptic drugs, epilepsy, monotherapy, polytherapy.

scholarly journals ADVANTAGES OF BROAD SPECTRUM ANTIEPILEPTIC DRUGS IN TREATMENT OF EPILEPSY

2017 ◽  
Vol 9 (1) ◽  
pp. 79-82
Author(s):  
K. V. Voronkova ◽  
G. S. Golosnaya ◽  
I. D. Lemeshko ◽  
A. S. Petrukhin
Keyword(s):  
Antiepileptic Drugs ◽  
Broad Spectrum ◽  
Treatment Of Epilepsy

scholarly journals Cognitive side effects of antiepileptic drugs in children

Neurology ◽  
2004 ◽  
Vol 62 (6) ◽  
pp. 872-877 ◽  
Author(s):  
D. W. Loring ◽  
K. J. Meador
Keyword(s):  
Side Effects ◽  
Antiepileptic Drugs ◽  
Cognitive Side Effects

Disulfiram-induced epileptic seizures

2021 ◽  
Vol 14 (3) ◽  
pp. e236296
Author(s):  
Violeta Nogueira ◽  
Mafalda Azevedo Mendes ◽  
Inês Pereira ◽  
Joana Teixeira
Keyword(s):  
Adverse Effect ◽  
Side Effects ◽  
Alcohol Consumption ◽  
Alcohol Dependence ◽  
Male Patient ◽  
Epileptic Seizure ◽  
Therapeutic Agent ◽  
Epileptic Seizures ◽  
Clinical Complications ◽  
Clonic Seizures

Disulfiram has been widely used for over six decades in the treatment of alcohol dependence, as an aversive therapeutic agent. Despite having very few side effects when taken without concurrent alcohol consumption, some of these may underlie serious clinical complications. Epileptic seizure induction is a rare adverse effect of disulfiram and its aetiological mechanism is unknown. We present a hospitalised 47-year-old male patient with two episodes of generalised tonic-clonic seizures during treatment with disulfiram while abstinent from alcohol.

Valproic Acid: A Different View

PEDIATRICS ◽  
1982 ◽  
Vol 70 (2) ◽  
pp. 331-331
Author(s):  
J. Kiffin Penry
Keyword(s):  
Valproic Acid ◽  
Side Effects ◽  
American Academy ◽  
Antiepileptic Drug ◽  
Antiepileptic Drugs ◽  
Published Data ◽  
American Academy Of Pediatrics

The Committee on Drugs of the American Academy of Pediatrics has prepared a statement on the benefits and risks of the antiepileptic drug valproic acid; this statement appears in this issue of Pediatrics (70:316, 1982). This report is extensive and objective in its review of published data on valproic acid, and is of great value to practicing pediatricians for that reason. However, the review fails to place vaiproic acid in perspective with other marketed antiepileptic drugs, which in many instances have equally serious side effects.

Drug treatment of epilepsy: From serendipitous discovery to evolutionary mechanisms

2021 ◽  
Vol 28 ◽  
Author(s):  
Shengying Lou ◽  
Sunliang Cui
Keyword(s):  
Drug Treatment ◽  
Antiepileptic Drugs ◽  
Brain Disorder ◽  
Evolutionary Mechanisms ◽  
Main Method ◽  
New Era ◽  
Treatment Of Epilepsy ◽  
New Antiepileptic Drugs ◽  
Novel Drugs ◽  
Voltage Gated Ion Channels

: Epilepsy is a chronic brain disorder caused by abnormal firing of neurons. Up to now, using antiepileptic drugs is the main method of epilepsy treatment. The development of antiepileptic drugs lasted for centuries. In general, most agents entering clinical practice act on the balance mechanisms of brain “excitability-inhibition”. More specifically, they target voltage-gated ion channels, GABAergic transmission and glutamatergic transmission. In recent years, some novel drugs representing new mechanisms of action have been discovered. Although there are about 30 available drugs in the market, it is still in urgent need of discovering more effective and safer drugs. The development of new antiepileptic drugs is into a new era: from serendipitous discovery to evolutionary mechanism-based design. This article presents an overview of drug treatment of epilepsy, including a series of traditional and novel drugs.

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