Clinical significance of measuring ADAMTS-13, its inhibitor and von Willebrand factor in obstetric and gynecological practice
2021 ◽
Vol 15
(1)
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pp. 93-106
Keyword(s):
ADAMTS-13 is a crucial metalloproteinase involved in liberating fragments of von Willebrand factor (vWF) into the plasma as well as regulating its activity by cleaving "ultra-large" multimers into smaller and less active counterparts. Many pathological conditions, including those emerged during pregnancy are characterized by increased level of vWF and decreased ADAMTS-13 activity. In this regard, it is necessary to monitor the levels of vWF and ADAMTS-13 activity to prevent thrombotic thrombocytopenic purpura (Moschcowitz disease) as one of the most severe forms of thrombotic microangiopathy.
1996 ◽
Vol 53
(4)
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pp. 213-220
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2000 ◽
Vol 65
(3)
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pp. 251-255
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2003 ◽
Vol 120
(5)
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pp. 821-824
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1986 ◽
Vol 291
(1)
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pp. 47-50
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1998 ◽
Vol 339
(22)
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pp. 1585-1594
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2006 ◽
Vol 32
(2)
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pp. 090-097
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