scholarly journals Role of phosphoinositide metabolism in multiple sclerosis pathogenesis

2021 ◽  
Vol XXX (3-4) ◽  
pp. 27-29
Author(s):  
М. М. Gerasimova ◽  
Т. V. Menshikova
Keyword(s):  
Multiple Sclerosis ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Immunocompetent Cells ◽  
Phosphoinositide Metabolism ◽  
Multiple Sclerosis Pathogenesis ◽  
Highly Effective ◽  
Layer Chromatography

Phosphoinositides in lymphocytes and machrophages in 20 patients with multiple sclerosis have been studied with the help of highly effective liquid and thin-layer chromatography. In all patients phosphoinositide metabolism inpairment was revealed, which can be caused both by impairment of phosphoinositide response of immunocompetent cells, and by connecting myelin with consequent demyelinization. The revealed fact may serve one of criteria of demyelinizathion process activity, and also evidences the certain role of the revealed impairment in multiple sclerosis pathogenesis.

Role of the solvent in thin-layer chromatography of steroids on alumina

1984 ◽  
Vol 18 (1) ◽  
pp. 37-40 ◽  
Author(s):  
S. M. Petrović ◽  
L. A. Kolarov ◽  
Julijana A. Petrović
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Layer Chromatography

Some Considerations on the Role of Water in Thin Layer Chromatography of Inorganic Anions

1984 ◽  
Vol 39 (2) ◽  
pp. 186-189
Author(s):  
Takaya Iida ◽  
Kaname Ito
Keyword(s):  
Thin Layer ◽  
Partition Coefficient ◽  
Thin Layer Chromatography ◽  
Partition Coefficients ◽  
Ionic Radius ◽  
Stationary Phases ◽  
Partial Charge ◽  
Layer Chromatography ◽  
Water Contents

The volume ratios of the mobile and stationary phases in thin layer chromatography, and the partition coefficients of halide and halate anions and some other anions between these phases were obtained by developing the ions simultaneously with a series of metaphosphates. The water contents of the developing solvents influenced the volume ratios very much, but not so much the partition coefficients. The logarithm of the partition coefficient of the halide anions is proportional to the reciprocal of their ionic radius, and that of the halate anions and oxoanions to the partial charge on the oxygens of them.

FLAVONOIDS ASSOCIATED WITH SPECIFIC GENE ACTION IN MAIZE ALEURONE, AND THE ROLE OF LIGHT IN SUBSTITUTING FOR THE ACTION OF A GENE

1970 ◽  
Vol 12 (4) ◽  
pp. 934-940 ◽  
Author(s):  
L. T. Kirby ◽  
E. D. Styles
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Biosynthetic Pathway ◽  
Gene Action ◽  
Specific Gene ◽  
Number Of Genes ◽  
Layer Chromatography ◽  
Role Of Light

A number of genes are known to be involved in the production of anthocyanin in maize aleurone. Thin layer chromatography has been used to detect specific flavonoids associated with the recessive forms of these genes. The results obtained so far indicate that the genes C1, C2, R and Pr all act before the formation of flavonol in the biosynthetic pathway, that A1 acts between flavanonol and 'flavenol' and that A2 acts between flavenol and anthocyanidin. Light substitutes for the action of the C1 gene in certain conditions and can be used to 'force' the system, causing a buildup of intermediate and side products beyond the C1 controlled step. The C1 gene probably controls a step between the C9 stage and flavanone.

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