The study of the effects of the combination of Himantane and Piribedil on a model of MPTP-induced parkinsonian syndrome in C57BL/6 mice
2019 ◽
Vol 17
(2)
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pp. 35-40
Keyword(s):
The effectiveness of hemantane, an original adamantane derivative, in combination with the dopamine receptor agonist piribedil on the model of acute parkinsonian syndrome induced by a single intraperitoneal injection of 30 mg/kg neurotoxicin-1, induced by a single intraperitoneal injection of 30 mg/kg neurotoxin 1-methyl-4-phenyl-tetrahydropyridine (MPTP) in C57BL/6 mice. Rigidity was assessed by stride length, oligokinesia and impaired coordination in the “rotarod test’’, effect on the catalepsy model caused by 0.1 mg/kg haloperidol. It has been established that the combination of hemantane and piribedil reduces the manifestations of parkinsonian syndrome, significantly exceeding in efficiency of each of the drugs separately.
Keyword(s):
1974 ◽
Vol 30
(5)
◽
pp. 383-386
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1988 ◽
Vol 88
(1)
◽
pp. 113-118
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1987 ◽
Vol 68
(1-2)
◽
pp. 41-50
◽
Keyword(s):
1995 ◽
Vol 18
(6)
◽
pp. 533-552
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