This chapter outlines two innovative sex- and gender-based biopsychosocial interventions: Couples Coping with Cancer Together and Single Fathers Due to Cancer. The foundation of each intervention is based on strengths inherent to the participants’ gender. Couples Coping with Cancer Together focuses on patients and partners during both active treatment and survivorship. Single Fathers Due to Cancer engages widowed fathers and their children. These two programs illustrate the relevance of sex (a one-time biological event determined at conception: male, female, intersex) and gender (how individuals defines themselves and their lives) differences in coping with the challenges of cancer. Future research is essential to empirically explore interventional studies that focus on gender-related strengths.