Conservative Surgical Approach to Pleomorphic Adenoma in Parotid Gland: Case Report

AbstractPleomorphic adenoma is a benign neoplasm of the salivary glands that affects most frequently females in the fourth and sixth decade of life. As it is usually an asymptomatic lesion, it is diagnosed upon routine physical examination. Treatment consists in surgical removal with partial or total involvement of the parotid gland. Conservative enucleation is the least invasive surgical option for this type of lesion. The present work aimed to report a case of pleomorphic adenoma of the parotid gland with eight years of evolution. The tumor was treated conservatively. Patient has been followed for sixth months, and no sensory alterations, fistulae, clinical signs of recurrence, nor any other alteration have been observed so far. Due to the benign nature of the lesion, an evolution with favorable prognosis is expected. Keywords: Adenoma. Benign Neoplasia. Tumor ResumoO Adenoma pleomórfico é uma neoplasia benigna de glândulas salivares, que acomete com maior frequência pessoas do sexo feminino entre a quarta e sexta década de vida. Por se tratar de uma lesão muitas vezes assintomática, geralmente é descoberta através do exame físico de rotina. O seu tratamento consiste em remoção cirúrgica podendo envolver ou não a glândula parótida de maneira parcial ou total. A enucleação conservadora é a modalidade cirúrgica menos invasiva para este tipo de lesão. O presente trabalho tem por objetivo relatar um caso de adenoma pleomórfico em glândula parótida com oito anos de evolução. O tumor foi tratado de maneira conservadora. A paciente está sendo acompanhada há 6 meses e não foram observados até momento alterações sensoriais, fistulas, indícios clínicos de recidiva ou qualquer outra alteração. Devido ao caráter benigno da lesão, espera-se evolução com prognóstico favorável. Palavras-chave: Adenoma. Neoplasia Benigna. Tumor.

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Conservative Surgical Approach to Pleomorphic Adenoma in Parotid Gland: Case Report

Journal of Health Sciences ◽

10.17921/2447-8938.2020v22n2p142-145 ◽

2020 ◽

Vol 22 (2) ◽

pp. 142-145

Author(s):

Davisson Alves Pereira ◽

Eduvaldo Campos Soares Júnior ◽

Mariana da Silva Bonatto ◽

Kallyne Munik Souza Morato ◽

André Luiz Fernandes da Silva

Keyword(s):

Parotid Gland ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Clinical Signs ◽

Benign Neoplasm ◽

Surgical Removal ◽

Favorable Prognosis ◽

Benign Nature ◽

Routine Physical Examination ◽

Sixth Decade

Abstract Pleomorphic adenoma is a benign neoplasm of the salivary glands that affects most frequently females in the fourth and sixth decade of life. As it is usually an asymptomatic lesion, it is diagnosed upon routine physical examination. Treatment consists of surgical removal with partial or total involvement of the parotid gland. Conservative enucleation is the least invasive surgical option for this type of lesion. The present work aimed at reporting a case of pleomorphic adenoma of the parotid gland with eight years of evolution. The tumor was treated conservatively. Patient has been followed for sixth months, and no sensory alterations, fistulae, clinical signs of recurrence, nor any other alterations have been observed so far. Due to the lesion benign nature, an evolution with favorable prognosis is expected. Keywords: Adenoma. Neoplasms. Salivary Glands. Resumo O Adenoma pleomórfico é uma neoplasia benigna de glândulas salivares, que acomete com maior frequência pessoas do sexo feminino entre a quarta e sexta década de vida. Por se tratar de uma lesão muitas vezes assintomática, geralmente é descoberta através do exame físico de rotina. O seu tratamento consiste em remoção cirúrgica podendo envolver ou não a glândula parótida de maneira parcial ou total. A enucleação conservadora é a modalidade cirúrgica menos invasiva para este tipo de lesão. O presente trabalho tem por objetivo relatar um caso de adenoma pleomórfico em glândula parótida com oito anos de evolução. O tumor foi tratado de maneira conservadora. A paciente está sendo acompanhada há 6 meses e não foram observados até momento alterações sensoriais, fistulas, indícios clínicos de recidiva ou qualquer outra alteração. Devido ao caráter benigno da lesão, espera-se evolução com prognóstico favorável. Palavras-chave: Adenoma. Neoplasias. Glândulas Salivares.

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Retrograde Facial Nerve Dissection Using Zygomatic Branch as Landmark in Parotid Gland Surgery for Pleomorphic Adenoma: A 4 Year Prospective Study of 40 Cases

Annals of International medical and Dental Research ◽

10.21276/aimdr.2018.4.3.sg5 ◽

2018 ◽

Vol 4 (3) ◽

Author(s):

Jayanth Kumar Biswal ◽

Jino Sebastian

Keyword(s):

Parotid Gland ◽

Facial Nerve ◽

Prospective Study ◽

Pleomorphic Adenoma

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Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma

Head and Neck Pathology ◽

10.1007/s12105-021-01299-4 ◽

2021 ◽

Author(s):

Costantino Ricci ◽

Federico Chiarucci ◽

Francesca Ambrosi ◽

Tiziana Balbi ◽

Barbara Corti ◽

...

Keyword(s):

Differential Diagnosis ◽

Salivary Gland ◽

Parotid Gland ◽

Pleomorphic Adenoma ◽

Salivary Gland Tumors ◽

Melanin Pigment ◽

Carcinoma Ex Pleomorphic Adenoma ◽

Pertinent Literature

AbstractThe presence of melanin pigment and melanocytic markers expression have been rarely reported in salivary gland tumors. Herein, two cases of carcinoma arising in pleomorphic adenoma of the parotid gland and showing diffuse expression of myoepithelial and melanocytic markers are described. The clinical-pathological clues useful in the differential diagnosis with melanoma are discussed. In addition, a review of the pertinent literature is also proposed, discussing the pathologic mechanisms potentially involved in this phenomenon.

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Hidradenoma papilliferum of the hymen: a case report

Journal of Medical Case Reports ◽

10.1186/s13256-021-02786-6 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Ozer Birge ◽

Mehmet Sait Bakır ◽

Ceyda Karadag ◽

Zivar Eldarova ◽

Tayup Simsek

Keyword(s):

Benign Neoplasm ◽

Surgical Removal ◽

Apocrine Glands ◽

Sexually Transmitted ◽

Anogenital Region ◽

Hidradenoma Papilliferum ◽

Anogenital Area ◽

Slow Growing

Abstract Background Hidradenoma papilliferum is a rare benign neoplasm arising from apocrine glands. It occurs commonly on the anogenital region of middle-aged women. It usually presents as a slow growing, solitary asymptomatic, skin colored or red nodule less than 1 cm in diameter. Case presentation The case is a 38-year-old, white woman who presented with a painful nodule occurring within a month in the himenal region of the posterior vaginal introitus. The nodule was excisied and the histology revealed a hidradenoma papilliferum. The diagnosis and treatment of hidradenoma papilliferum is possible with surgical removal and histopathological evaluation of nodules. Conclusion When an adult woman presents with a noduler lesion in the anogenital area, sexually transmitted diseases and other benign and malignant vulvar lesions, as well as malignant transformation is very rare but,should be kept in mind; however because it has been reported and long-term clinical follow-up is suggested

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Giant Cell Carcinosarcoma of the Parotid Gland With a PLAG 1 Translocation in Association With a Pleomorphic Adenoma With HMGA2 Translocation

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqaa104 ◽

2020 ◽

Vol 154 (6) ◽

pp. 811-815

Author(s):

Levon Katsakhyan ◽

Virginia A LiVolsi ◽

Ara A Chalian ◽

Paul J Zhang

Keyword(s):

Salivary Gland ◽

In Situ Hybridization ◽

Parotid Gland ◽

Giant Cell ◽

Pleomorphic Adenoma ◽

De Novo ◽

Sarcomatous Component ◽

Gland Tumor ◽

Parotid Gland Tumor

Abstract Objectives Carcinosarcomas of the salivary gland are rare neoplasms and have been described arising de novo or in association with pleomorphic adenoma (PA). PLAG1 and HMGA2 translocations are known to occur in PAs and carcinomas ex PA but are mutually exclusive. Methods We report a case of a carcinosarcoma in the parotid gland of a 77-year-old man with unusual anaplastic sarcomatoid giant cell morphology. Results Microscopically, a small separate PA was found adjacent to the carcinosarcoma. By conventional notion, the PA and carcinosarcoma would be considered related, as carcinosarcomas are well known to arise from PAs (carcinosarcoma ex PA). However, fluorescence in situ hybridization (FISH) assay demonstrated PLAG1 translocation in the carcinosarcoma and HMGA2 translocation in the separate PA. Conclusions These findings support that the carcinosarcoma likely originated from another PA with a PLAG1 translocation or de novo but not from the coexisting PA harboring a different translocation. To our knowledge, the case is the first to demonstrate PLAG1 translocation by FISH in a sarcomatous component of any parotid gland tumor, which may help better classify these tumors. In addition, multiple PAs are commonly found in the salivary gland, and to our knowledge, our case is the first to demonstrate that the same parotid gland can host PAs and PA-related tumors with different translocations.

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