Botulinum Toxin Type A and Post-stroke Spasticity of the Upper Limbs

US Neurology ◽  
2009 ◽  
Vol 05 (01) ◽  
pp. 38
Author(s):  
Cindy B Ivanhoe ◽  
Natasha K Eaddy-Rose ◽  
◽  
Keyword(s):  
Botulinum Toxin ◽  
Upper Limb ◽  
Daily Living ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Upper Limbs ◽  
Post Stroke ◽  
The Us ◽  
Developed Nations

Background:Stroke is a significant contributor to morbidity and mortality in the US and other developed nations. Stroke and its side effects are the primary cause of disability in the US and worldwide. Upper limb mobility factors are particularly detrimental to activities of daily living. Successful treatments to improve post-stroke spasticity are required.Objective:To assess the relevant medical literature related to the use of botulinum toxin type A and post-stroke spasticity of the upper limb.Methods:Literature review utilizing Medline with keywords of botulinum toxin, stroke, spasticity, and upper extremity since 2003.Results:Thirteen criteria-based articles investigated botulinum toxin type and poststroke spasticity of the upper limbs. Discussion: Botulinum toxin type A is an effective agent in reducing post-stroke spasticity of the upper limbs.

Botulinum toxin type A in post-stroke upper limb spasticity

2010 ◽  
Vol 26 (8) ◽  
pp. 1983-1992 ◽  
Author(s):  
Ryuji Kaji ◽  
Yuka Osako ◽  
Kazuaki Suyama ◽  
Toshio Maeda ◽  
Yasuyuki Uechi ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Upper Limb ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Post Stroke ◽  
Limb Spasticity

scholarly journals Efficacy of physical therapy associated with botulinum toxin type A on functional performance in post-stroke spasticity: A randomized, double-blinded, placebo-controlled trial

2018 ◽  
Vol 10 (2) ◽  
Author(s):  
Antonio Prazeres ◽  
Marília Lira ◽  
Paula Aguiar ◽  
Larissa Monteiro ◽  
Ítalo Vilasbôas ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Physical Therapy ◽  
Functional Performance ◽  
Controlled Trial ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Upper Limbs ◽  
Post Stroke ◽  
Double Blinded

The aim was to investigate if botulinum toxin type A (BTx-A) associated with physical therapy is superior to physical therapy alone in post stroke spasticity. A randomized, double-blinded controlled trial was performed in a rehabilitation unit on Northeastern, Brazil. Patients with post stroke spasticity were enrolled either to BTx-A injections and a pre-defined program of physical therapy or saline injections plus physical therapy. Primary endpoint was functional performance evaluated through time up and go test, six minutes walking test and Fugl-Meyer scale for upper limb. Secondary endpoint was spasticity improvement. Confidence interval was considered at 95%. Although there was a significant decrease in upper limbs flexor tonus (P<0.05) in the BTx-A group, there was no difference regarding functional performance after 9 months of treatment. When analyzing gait speed and performance, both groups showed a significant improvement in the third month of treatment, however it was not sustained over time. Although BTx-A shows superiority to improve muscle tone, physical therapy is the cornerstone to improve function in the upper limbs of post stroke patients.

Systematic review of the use of botulinum toxin type A during treatment of post-stroke spasticity of the upper limb

2019 ◽  
Vol 17 (7) ◽  
pp. 38-45
Author(s):  
D. L. Klabukova ◽  
◽  
V. S. Krysanova ◽  
T. N. Ermolaeva ◽  
M. V. Davydovskaya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Botulinum Toxin ◽  
Upper Limb ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Post Stroke
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