scholarly journals Functional state of a sphingomyeline cycle and free radical lipid oxidation activity of a rat's liver during different phases of starvation

2012 ◽  
Vol 58 (5) ◽  
pp. 556-563
Author(s):  
D.I. Kuzmenko ◽  
P.G. Burov ◽  
V.Yu. Serebrov ◽  
E.A. Fait ◽  
T.V. Perevozchikova
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Lipid Oxidation ◽  
Functional State ◽  
Antioxidant Defense ◽  
Metabolic Adaptation ◽  
Control Group ◽  
Neutral Sphingomyelinase ◽  
Free Radical Lipid Oxidation ◽  
Free Radical Lipid

The functional state of a sphingomyeline cycle and character of its mutual relations with the processes of free radical lipid oxidation during starvation of animals without any restriction of access to drinking water at 1, 2, 3 day (I phase) and 6 day (II phase of starvation) were studied at the liver of rats. The maximal values of the ceramide/sphingomyeline ratio and activity neutral sphingomyelinase and executive caspase-3 were reached in a liver of animals at the 3rd day of starvation . From the 3rd day of starvation the concentration of the tumour necrosis factor-α which is one of activators neutral sphingomyelinase was increase in rats blood serum. During the extent of large part of the I phase of starvation the intensity of free radical lipid peroxidation in a liver had almost the same level as in control group - that was a result of the high-grade functioning of antioxidant defense system. After transition the I phase of starvation into the II phase (6 day of experiment) the oxidative stress was developed as result of an exhaustion of system antioxidant defense potential in a liver. The results of this data can testify that during I phase of starvation in a liver the conditions was raised for display of the ceramide-mediated proapoptotic signalling. We assume that ceramide-mediated apoptosis is one of mechanisms of optimization of liver cellular population at the frames of metabolic adaptation. The I phase of starvation in a liver proves by the ceramide-mediated proapoptotic signaling developing. During the II phase of starvation the oxidative stress process were prevailed.

scholarly journals FEATURES OF CLINICAL MANIFESTATIONS, FREE RADICAL, COAGULATION AND AGGREGATION PROPERTIES OF BLOOD IN PATIENTS WITH CRANIOCEREBRAL TRAUMA

2019 ◽  
Vol 72 (4) ◽  
pp. 539-542
Author(s):  
Viktoriia A. Pinchuk ◽  
Galyna Ya. Sylenko ◽  
Yurii I. Sylenko ◽  
Angelina M. Kryvchun ◽  
Tetiana V. Pilugina
Keyword(s):  
Free Radical ◽  
Lipid Oxidation ◽  
Craniocerebral Trauma ◽  
Free Radical Oxidation ◽  
Control Group ◽  
Radical Oxidation ◽  
Number Of Patients ◽  
Free Radical Lipid Oxidation ◽  
Free Radical Lipid ◽  
Apparently Healthy

Introduction: In recent years in Ukraine, as in the entire world, there has been an increase in cases of domestic injuries with a raise in the number of patients with craniocerebral trauma and its consequences. The aim of our research was to study clinical symptoms, the state of free radical oxidation, aggregate and hemocoagulative properties of blood in patients with mild craniocerebral trauma. Materials and methods: We conducted comprehensive clinical and laboratory examination of 34 patients with mild craniocerebral trauma and 20 apparently healthy patients (the control group). The diagnosis was made under ICD-10. The verification of the diagnosis was based on data from clinical examination, neurological status of neuroimaging (computer tomography and magnetic resonance imaging). The study group included 24 men and 10 women aged from 19 to 40. In addition, 20 apparently healthy individuals of the same age were examined, who comprised the control group (14 men and 6 women). In the blood parameters of all patients, we examined free radical oxidation, hemostasis and aggregation properties of platelets. Results: The conducted study revealed clinical disturbances, changes in the parameters of free radical lipid oxidation, coagulation and microcirculatory hemostasis. Conclusions: All patients with mild craniocerebral trauma, develop disturbances in the form of symptoms of microorganic lesion of the central nervous system: convergence weakness in 100% of patients, Mann’s symptom (76.4%), disruption of the function of the cranial nerves (58.8%), signs of pyramidal insufficiency (68.4%), vestibular disorders (94.1%), autonomic vascular dysfunction (100%). Mild craniocerebral trauma is accompanied by the activation of free radical lipid oxidation processes, decreased activity of antioxidant enzymes, hypercoagulation, and increased aggregation properties of platelets.

Relationship between free-radical lipid oxidation and efficiency of coronary angioplasty in coronary patients

2007 ◽  
Vol 144 (5) ◽  
pp. 664-666 ◽  
Author(s):  
A. I. Kaminnyi ◽  
V. Z. Lankin ◽  
E. I. Perepelitsa ◽  
G. G. Konovalova ◽  
A. N. Samko ◽  
...  
Keyword(s):  
Free Radical ◽  
Lipid Oxidation ◽  
Coronary Angioplasty ◽  
Coronary Patients ◽  
Free Radical Lipid Oxidation ◽  
Free Radical Lipid

Experimental effect of some hormones on the intensity of the free-radical lipid oxidation reaction

1978 ◽  
Vol 86 (5) ◽  
pp. 1436-1438 ◽  
Author(s):  
V. Yu. Kulikov ◽  
V. P. Kaznacheev ◽  
L. V. Molchanova ◽  
V. V. Ermolaeva ◽  
Z. T. Bikbulatov
Keyword(s):  
Free Radical ◽  
Lipid Oxidation ◽  
Oxidation Reaction ◽  
Experimental Effect ◽  
Free Radical Lipid Oxidation ◽  
Free Radical Lipid
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