scholarly journals Patterns of Cross-Reactivity in Patients with Immediate Hypersensitivity Reactions to Gadobrutol

2021 ◽  
Vol 31 (6) ◽  
Author(s):  
A Gallardo-Higueras ◽  
EM Moreno ◽  
FJ Muñoz-Bellido ◽  
E Laffond ◽  
MT Gracia-Bara ◽  
...  
Keyword(s):  
Cross Reactivity ◽  
Hypersensitivity Reactions ◽  
Immediate Hypersensitivity

scholarly journals Value of Skin Tests for Managing Hypersensitivity Reactions to Platinum Salts

2021 ◽  
Author(s):  
Laura Pedraza-Nieto ◽  
Monica Beunza-Sola ◽  
Cesar A Rodríguez ◽  
Esther Moreno ◽  
María José Otero
Keyword(s):  
Cross Reactivity ◽  
Skin Tests ◽  
Hypersensitivity Reactions ◽  
Single Center ◽  
Immediate Hypersensitivity ◽  
Accurate Identification ◽  
Platinum Salts ◽  
Platinum Based Chemotherapy ◽  
Different Types ◽  
Platinum Salt

Abstract Background: Platinum-based therapy continues to be one of the pillars of the treatment of different types of cancer. However, many times the responsible clinician renounces its use after the appearance of a hypersensitivity reaction.Objective: To assess the value of skin tests (ST) in clinical practice to address the treatment of patients with suspicion of immediate hypersensitivity reactions (HSRs) to platinum salts.Methods: Single-center retrospective study performed for 3 years. Adult patients treated with any platinum salt who experienced HSR symptoms and for whom an oncologist requested ST, were included. ST with cisplatin, carboplatin and oxaliplatin were performed. Results: Twenty-two patients were included. ST were positive in 12 patients (54.5%), of which 4 (33%) presented cross-reactivity to another platinum salt. Fifteen patients continued platinum-based chemotherapy: 9 patients with positive ST (4 continued by desensitization and 5 with another platinum) and 6 patients with negative ST, of which 1 repeated an HSR. A NPV of 0.91 was calculated. Conclusion: ST allowed accurate identification of platinum allergy patients and the resumption of platinum-based therapy in many patients for whom no suitable therapeutic alternative was clinically acceptable.

Delayed and immediate hypersensitivity reactions associated with the use of amalgam

BDJ ◽  
2000 ◽  
Vol 188 (2) ◽  
pp. 73-76 ◽  
Author(s):  
B McGivern ◽  
M Pemberton ◽  
E D Theaker ◽  
J A G Buchanan ◽  
M H Thornhill
Keyword(s):  
Hypersensitivity Reactions ◽  
Immediate Hypersensitivity

Immediate hypersensitivity reactions of the heart: Reduction of tachycardia and arrhythmias by the SRS-A antagonist FPL 55712

1980 ◽  
Vol 2 (2) ◽  
pp. 173-176 ◽  
Author(s):  
Roberto Levi ◽  
James A. Burke ◽  
Betsy A. Holland ◽  
Frank J. Green
Keyword(s):  
Hypersensitivity Reactions ◽  
Immediate Hypersensitivity

scholarly journals Safety Assessment of Hydrolyzed Wheat Protein and Hydrolyzed Wheat Gluten as Used in Cosmetics

2018 ◽  
Vol 37 (1_suppl) ◽  
pp. 55S-66S ◽  
Author(s):  
Christina Burnett ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
Curtis D. Klaassen ◽  
...  
Keyword(s):  
Safety Assessment ◽  
Expert Panel ◽  
Average Molecular Weight ◽  
Wheat Gluten ◽  
Safety Data ◽  
Hypersensitivity Reactions ◽  
Wheat Protein ◽  
Laboratory Studies ◽  
Immediate Hypersensitivity

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed the product use, formulation, and safety data on hydrolyzed wheat protein and hydrolyzed wheat gluten, which function as skin- and hair-conditioning agents. The Panel determined that data from clinical and laboratory studies were sufficient to demonstrate that these ingredients will not elicit type 1 immediate hypersensitivity reactions in sensitized individuals and will not induce sensitization when the polypeptide lengths of the hydrolysates do not exceed 30 amino acids. The Panel concluded that hydrolyzed wheat gluten and hydrolyzed wheat protein are safe for use in cosmetics when formulated to restrict peptides to an average molecular weight of 3,500 Da or less.

Lung volumes after antigen infusion in the guinea pig in vivo: effects of vagal section

1978 ◽  
Vol 45 (6) ◽  
pp. 957-961 ◽  
Author(s):  
J. M. Drazen ◽  
S. H. Loring ◽  
C. Venugopalan
Keyword(s):  
Total Lung Capacity ◽  
Hypersensitivity Reactions ◽  
Immediate Hypersensitivity ◽  
Similar Extent ◽  
Static Compliance ◽  
Lung Volumes ◽  
Lung Capacity ◽  
In Vivo Effects ◽  
Gas Volume

The effects of intravenous antigen infusion on lung volumes and quasi-static deflationary pulmonary compliance in guinea pigs previously sensitized to ovalbumin were studied in vivo. Ovalbumin infusion significantly increased minimal gas volume to a similar extent in animals with intact or cut vagi. Total lung capacity fell only in animals with intact vagi. Quasi-static compliance fell in both groups of animals, but the fall was significantly greater in animals with intact vagi. These data demonstrate that immediate hypersensitivity reactions alter lung volumes and the elastic properties of the lung by both vagal dependent and vagal independent mechanisms.

Hypersensitivity reactions to proton-pump inhibitors: Clinical presentation, diagnosis, and management

2020 ◽  
Vol 41 (2) ◽  
pp. e37-e44 ◽  
Author(s):  
Seçil Kepil Özdemir ◽  
Sevim Bavbek
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Clinical Presentation ◽  
Current Knowledge ◽  
Cross Reactivity ◽  
Delayed Hypersensitivity ◽  
Stevens Johnson Syndrome ◽  
Hypersensitivity Reactions ◽  
Fixed Drug Eruption ◽  
Maculopapular Eruption

Background: Proton-pump inhibitors (PPI) are one of the most commonly prescribed drugs, and they are generally well tolerated. However, several immediate and delayed hypersensitivity reactions due to PPIs have been reported. Objective: To review the clinical characteristics and management of immune-mediated immediate and delayed hypersensitivity reactions to PPIs. Methods: We performed a search of a medical literature data base from January 1980 to October 2019 by using keywords that included “proton-pump inhibitors” and “hypersensitivity.” Results: Anaphylaxis is the most-common clinical presentation in patients with immediate hypersensitivity reactions to PPIs, followed by urticaria and/or angioedema. Occupational contact dermatitis, maculopapular eruption, fixed drug eruption, symmetrical drug-related intertriginous and flexural exanthema, and severe cutaneous adverse reactions, such as Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, and acute generalized exanthematous pustulosis have also been reported with PPIs. Conclusion: The current knowledge and severity of the reported reactions indicated the importance of consideration of a causal relationship between hypersensitivity reactions and PPIs, and awareness of the existence of cross-reactivity among PPIs.

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