scholarly journals Primary malignant melanoma of vagina: a case report

2020 ◽  
Vol 9 (8) ◽  
pp. 3499
Author(s):  
Smruti Shambharkar ◽  
Tarachand Sharma
Keyword(s):  
Malignant Melanoma ◽  
Firm Growth ◽  
Histopathological Examination ◽  
Lateral Wall ◽  
Primary Malignant Melanoma ◽  
Malignant Neoplasms ◽  
Vaginal Examination ◽  
Aggressive Disease ◽  
History Of ◽  
Worse Prognosis

Primary malignant melanoma of the vagina is a rare and aggressive disease with worse prognosis as compared with non-genital melanomas or other vaginal malignant neoplasms. Presented here is a case of 42 years female with 3 months history of amenorrhea and vaginal discharge. On vaginal examination, a firm growth of size approximately 7-8 cm was found attached to the left postero-lateral wall of vagina and extending up to the introitus. On biopsy and histopathological examination, it was diagnosed as a case of high-grade malignant melanoma of amelanotic type. Radiotherapy was started as a part of treatment after consultation with an oncologist, considering non-resectable nature of the mass. The patient received first 5 cycles of radiotherapy but succumbed to the disease during treatment.

scholarly journals Primary Malignant Melanoma of the Tonsil : A Case Report

2009 ◽  
Vol 22 (2) ◽  
pp. 279-281
Author(s):  
SM Badruddoza ◽  
S Naz
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Sore Throat ◽  
Male Patient ◽  
Clinical Examination ◽  
Histopathological Examination ◽  
Primary Malignant Melanoma ◽  
Polypoid Mass ◽  
Current Case ◽  
History Of

Malignant melanoma is a neoplasm of melanocytes. Primary malignant melanoma of the oronasal region is rare. When it does occur, it is difficult to manage, and the prognosis is not good. The current case was a 48 years old male patient who presented with history of sore throat, pain in left tonsillar region, hemoptysis with difficulty in swallowing. Clinical examination revealed a blackish ulcerated polypoid mass in the left palatine tonsil. Left sided tonsilectomy was done. Histopathological examination revealed primary malignant melanoma of the tonsil.TAJ 2009; 22(1): 279-281

scholarly journals Primary Esophageal Melanoma with Aberrant CD56 Expression: A Potential Diagnostic Pitfall

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Hani Katerji ◽  
John M. Childs ◽  
Laura E. Bratton ◽  
Christian G. Peyre ◽  
Aaron R. Huber
Keyword(s):  
Malignant Melanoma ◽  
Malignant Neoplasms ◽  
Aggressive Disease ◽  
Immunohistochemical Markers ◽  
Diagnostic Pitfall ◽  
Divergent Differentiation ◽  
Erroneous Diagnosis ◽  
Cd56 Expression ◽  
Poorly Differentiated ◽  
Esophageal Malignant Melanoma

Primary esophageal malignant melanoma (MM) is rare and extremely aggressive. For pathologists, it can be challenging to diagnose and differentiate from other poorly differentiated malignant neoplasms in the esophagus. Complicating this fact, MM can have divergent differentiation and express nonmelanocytic immunohistochemical markers including epithelial markers (cytokeratins) and rarely neuroendocrine markers. Lack of awareness of this fact by a pathologist can lead to an erroneous diagnosis and delay treatment for an already aggressive disease. Herein, we report a case of primary esophageal malignant melanoma with aberrant CD56 expression without accompanying synaptophysin or chromogranin expression.

scholarly journals Primary Spinal Cord Melanoma of Intradural Extramedullary Origin

2019 ◽  
Vol 10 (03) ◽  
pp. 522-525
Author(s):  
Ashish Sharma ◽  
Virendra Deo Sinha
Keyword(s):  
Spinal Cord ◽  
Malignant Melanoma ◽  
Histopathological Examination ◽  
Lower Limbs ◽  
Primary Malignant Melanoma ◽  
Magnetic Resonance Imaging Scan ◽  
Lumbosacral Region ◽  
Intensity Lesion ◽  
S 100 ◽  
L1 And L2

AbstractPrimary malignant melanoma is the very rare entity of the central nervous system. It accounts only 1% of all melanoma cases. A 67-year-old patient presented to us with lower back pain radiating to the left lower limb and progressive weakness of both lower limbs. She underwent magnetic resonance imaging scan of lumbosacral region that suggested T1 hyperintense, T2 hypointense, extramedullary altered signal intensity lesion at L1 and L2 vertebral level compressing terminal spinal cord, and cauda equine region. On histopathological examination, findings were suggestive of malignant melanoma that was confirmed with immunohistochemistry examination (positive for S-100, Melan-A, and HMB-45). Here, we are discussing an unusual case of primary malignant melanoma of conus and cauda equine region with comprehensive review regarding management and prognosis of the tumor.

scholarly journals Conservative management of primary malignant melanoma of the bladder: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Sebastiano Rapisarda ◽  
Maida Bada ◽  
Andrea Polara ◽  
Felice Crocetto ◽  
Massimiliano Creta ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Bladder Tumor ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Clinical History ◽  
Metastatic Malignant Melanoma ◽  
Primary Malignant Melanoma ◽  
Bacillus Calmette Guerin ◽  
Endoscopic Evaluation ◽  
Case Presentation

Abstract Background Primary malignant melanoma (PMM) of the bladder represents a very rare clinic-pathologic entity. Given the rarity of the disease, the best treatment option is not well recognized. Case presentation We describe a case of neoplasm of the bladder in a 74 years-old Caucasian man presenting with massive hematuria. Based on clinical, instrumental and histological findings a diagnosis of PMM was made. The patient underwent trans urethral resection of bladder tumor plus intravesical Bacillus Calmette–Guérin. Conclusions To make a correct diagnosis, clinical history, endoscopic evaluation, histopathological examination and immunohistochemistry, are necessary. Multidisciplinary evaluation is required to discriminate primary from metastatic malignant melanoma.

Sub-Ungual Malignant Melanoma Presenting as Sub-Acute Paronychia Following Trauma

HAND ◽  
1977 ◽  
Vol os-9 (1) ◽  
pp. 49-51 ◽  
Author(s):  
J. W. Ware
Keyword(s):  
Malignant Melanoma ◽  
Primary Malignant Melanoma ◽  
History Of

A woman presenting with a history of trauma to her thumb, apparently followed by sub-acute paronychia, is subsequently shown to have primary malignant melanoma at the site. The case serves as a reminder that wolves can appear in sheep's clothing.

Spontaneous urinary bladder perforation: An unusual presentation of well-differentiated papillary peritoneum mesothelioma

2021 ◽  
pp. 039156032110011
Author(s):  
Armando Serao ◽  
Francesca Ambrosini ◽  
Barbara Cavallone ◽  
Tiziana Borra ◽  
Andrea Di Stasio
Keyword(s):  
Histopathological Examination ◽  
Lateral Wall ◽  
Exploratory Laparotomy ◽  
Bladder Rupture ◽  
Free Fluid ◽  
Case Presentation ◽  
Left Lateral Wall ◽  
Intraperitoneal Bladder Rupture ◽  
History Of ◽  
Well Differentiated

Introduction: Well-differentiated papillary mesothelioma (WDPM) is a very rare neoplasm. Most of WDPM are asymptomatic and are often incidentally detected during surgery. This report describes a case of WDPM of the peritoneum unexpectedly diagnosed in a male with a spontaneous intraperitoneal bladder rupture. Case presentation: A 65-year-old male presented to our Emergency Department in November 2019 with a two-day history of anuria, abdominal pain, distention, and sepsis. The CT scan reported a large amount of extra and intraperitoneal free fluid. The CT cystogram showed bladder perforations on the dome and on the left lateral wall which was repaired through exploratory laparotomy. Intraoperatively, we encountered extensive suppurative peritonitis with large fibrino-purulent exudation. The purulent perivesical peritoneum was dissected and sent for histopathological examination which unexpectedly resulted in WDPM of the peritoneum. Conclusion: Although we can’t affirm with certainty, this case would seem to suggest that WDPM had played a role in patient’s clinical presentation. However, further research is necessary to draw stronger conclusion.

scholarly journals Primary malignant melanoma of female urethra: a case report and review of literature

2020 ◽  
Vol 1 (3) ◽  
Author(s):  
Shashank Agrawal ◽  
Tak GR ◽  
Aditya Parikh ◽  
Arvind Prakash Ganpule ◽  
Abhishek Gajendra Singh ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Protein S ◽  
Primary Malignant Melanoma ◽  
Female Urethra ◽  
Inguinal Lymph Node Dissection ◽  
Rare Case Report ◽  
S 100 ◽  
History Of ◽  
Poorly Differentiated

We report an extremely rare case report of primary malignant melanoma of female urethra. A 65 years old diabetic elderly postmenopausal female presented with a history of intermittent blood spots on undergarments for few days. Genital examination revealed a single, tan colored, soft chestnut size and polypoidal non ulcerated mass lesion protruding through the urethral meatus. Mass biopsy revealed poorly differentiated epithelial malignancy and immuno-histological analysis revealed positive with HMB 45 and protein S-100 suggestive of melanoma. Metastatic work up for the malignancy was negative. Complete urethrectomy with Mitrofanoff procedure with inguinal lymph node dissection was performed. Pathological diagnosis was malignant melanoma of urethra. We discuss the clinicopathological features and treatment option possible in this scenario.

scholarly journals Malignant Melanoma: presentation as a primary retroperitoneal tumor

2016 ◽  
Vol 10 (4) ◽  
Author(s):  
Fraz Fahim ◽  
Muhammad Farooq Afzal ◽  
Mahmood Ayyaz ◽  
Sheema Fahim
Keyword(s):  
Malignant Melanoma ◽  
Past History ◽  
District General Hospital ◽  
Primary Malignant Melanoma ◽  
Retroperitoneal Mass ◽  
Presumptive Diagnosis ◽  
Extensive Search ◽  
History Of ◽  
Right Lobe ◽  
Primary Retroperitoneal

This is a case report of an extremely rare primary malignant melanoma presenting in the retroperitoneum of a 30 years old female. She was operated in a District General Hospital with a presumptive diagnosis of hydatid cyst of right lobe of liver. The patient bled profusely on exploration and the surgeon packed the abdomen and referred her to our emergency, where she was received in shock. After resuscitation she was operated on the next available list and was found to have a very vascular, pigmented, retroperitoneal mass measuring 10-x 12-cm lying in front of the infrarenal IVC pushing the duodenum towards the midline. It was completely excised. Histopathology showed it to be a malignant melanoma. Upon subsequent examination and extensive workup, no evidence of a primary malignant melanoma was found. There was no past history of a melanoma which may have regressed spontaneously or excised. After extensive search of literature we could not find another report of a primary retroperitoneal melanoma.

Primary Malignant Melanoma of the Larynx

2001 ◽  
Vol 125 (2) ◽  
pp. 271-273 ◽  
Author(s):  
Hesham M. Amin ◽  
Guy J. Petruzzelli ◽  
Aliya N. Husain ◽  
Brian J. Nickoloff
Keyword(s):  
Malignant Melanoma ◽  
Clinical Evidence ◽  
Medical Literature ◽  
Excisional Biopsy ◽  
Primary Malignant Melanoma ◽  
Melanocytic Lesions ◽  
History Of ◽  
Abnormal Mitoses ◽  
Immunohistochemical Studies

Abstract Primary malignant melanoma of the larynx is a rare clinical entity. Only 53 cases have been reported in the medical literature to date. This report describes a case of primary malignant melanoma arising in the larynx and diagnosed by histologic examination of an excisional biopsy specimen. The patient was a 53-year-old man with a history of smoking and hoarseness. There was no clinical evidence of other primary malignant melanocytic lesions. Microscopically, the tumor consisted of polygonal-epithelioid cells admixed with more elongated, spindle-shaped cells. The majority of the cells demonstrated dark brown cytoplasmic and nuclear melanin. Marked pleomorphism and abnormal mitoses were also identified. Despite significant ulceration and disruption of the epithelium, in situ malignant melanocytes were recognized within the remaining portion of the epithelium. Immunohistochemical studies were positive for S100, HMB-45, and vimentin, while cytokeratin and iron stains were negative. Based on the clinical and histologic findings, a diagnosis of primary malignant melanoma of the larynx was established.

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