scholarly journals Primary Spinal Cord Melanoma of Intradural Extramedullary Origin

2019 ◽  
Vol 10 (03) ◽  
pp. 522-525
Author(s):  
Ashish Sharma ◽  
Virendra Deo Sinha
Keyword(s):  
Spinal Cord ◽  
Malignant Melanoma ◽  
Histopathological Examination ◽  
Lower Limbs ◽  
Primary Malignant Melanoma ◽  
Magnetic Resonance Imaging Scan ◽  
Lumbosacral Region ◽  
Intensity Lesion ◽  
S 100 ◽  
L1 And L2

AbstractPrimary malignant melanoma is the very rare entity of the central nervous system. It accounts only 1% of all melanoma cases. A 67-year-old patient presented to us with lower back pain radiating to the left lower limb and progressive weakness of both lower limbs. She underwent magnetic resonance imaging scan of lumbosacral region that suggested T1 hyperintense, T2 hypointense, extramedullary altered signal intensity lesion at L1 and L2 vertebral level compressing terminal spinal cord, and cauda equine region. On histopathological examination, findings were suggestive of malignant melanoma that was confirmed with immunohistochemistry examination (positive for S-100, Melan-A, and HMB-45). Here, we are discussing an unusual case of primary malignant melanoma of conus and cauda equine region with comprehensive review regarding management and prognosis of the tumor.

scholarly journals A Case of Primary Subglottic Malignant Melanoma with a Successful Surgical Treatment

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Shahzad Ahmad ◽  
Mahmoud Abdelghany ◽  
Curtis Goldblatt ◽  
Owen Stark ◽  
Nicholas Masciotra
Keyword(s):  
Surgical Treatment ◽  
Malignant Melanoma ◽  
Excisional Biopsy ◽  
Human Melanoma ◽  
Primary Malignant Melanoma ◽  
Shortness Of Breath ◽  
S 100 ◽  
Hmb 45

Primary subglottic malignant melanoma is a very rare and underdiagnosed neoplasm. We are reporting a case of primary malignant melanoma of subglottic mucosa in a 78-year-old woman who presented to our hospital with shortness of breath and hoarseness of voice. Laryngoscopy and excisional biopsy along with immunoreactivity to S-100 and human melanoma black-45 (HMB-45) confirmed the diagnosis. The patient was treated with laryngectomy followed by radiotherapy. Five years following surgical treatment, she continues to be asymptomatic. To our knowledge, there is only one reported case of primary malignant melanoma of subglottic mucosa in the medical literatures.

scholarly journals Primary Melanoma of the Lung: A Systematic Review

Medicina ◽  
2020 ◽  
Vol 56 (11) ◽  
pp. 576
Author(s):  
Panagiotis Paliogiannis ◽  
Antonella M. Fara ◽  
Gianfranco Pintus ◽  
Wael M. Abdel-Rahman ◽  
Maria Colombino ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Single Case ◽  
Left Lung ◽  
Case Series ◽  
Primary Melanoma ◽  
Primary Malignant Melanoma ◽  
S 100 ◽  
Main Determinants ◽  
Mitotic Figures ◽  
Rare Malignancy

Background and Objectives: The respiratory apparatus, generally affected by highly aggressive tumors like lung cancer and mesothelioma, is rarely affected by primary malignant melanoma. The aim of this review was to identify cases of primary malignant melanoma of the lung (PMML) published in the modern scientific literature, and to describe their main clinical, pathological and therapeutic features. Materials and Methods: A systematic search of publications in the electronic database PubMed has been performed using keywords, and the references of the selected articles were checked to identify additional missing studies. Results: Globally 52 papers reporting on 76 cases were identified. Among them there were 47 reports of a single case, three papers reporting on two cases each, and two larger case series published in 1997 and 2005 including eight and 15 cases, respectively. Conclusions: PMML was generally diagnosed in middle-aged males, without any apparent correlation with cigarette smoking. It was more frequently found in the lower lobes and the left lung. The tumors were generally pigmented, composed by epithelial and/or spindle cells with large nuclei and prominent nucleoli, nuclear atypia, and numerous mitotic figures; they commonly showed immunostaining for S-100, HMB 45 and Melan-A. Early detection and surgical resection were the main determinants of survival from this rare malignancy.

scholarly journals Conservative management of primary malignant melanoma of the bladder: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Sebastiano Rapisarda ◽  
Maida Bada ◽  
Andrea Polara ◽  
Felice Crocetto ◽  
Massimiliano Creta ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Bladder Tumor ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Clinical History ◽  
Metastatic Malignant Melanoma ◽  
Primary Malignant Melanoma ◽  
Bacillus Calmette Guerin ◽  
Endoscopic Evaluation ◽  
Case Presentation

Abstract Background Primary malignant melanoma (PMM) of the bladder represents a very rare clinic-pathologic entity. Given the rarity of the disease, the best treatment option is not well recognized. Case presentation We describe a case of neoplasm of the bladder in a 74 years-old Caucasian man presenting with massive hematuria. Based on clinical, instrumental and histological findings a diagnosis of PMM was made. The patient underwent trans urethral resection of bladder tumor plus intravesical Bacillus Calmette–Guérin. Conclusions To make a correct diagnosis, clinical history, endoscopic evaluation, histopathological examination and immunohistochemistry, are necessary. Multidisciplinary evaluation is required to discriminate primary from metastatic malignant melanoma.

scholarly journals Primary Malignant Melanoma of the Tonsil : A Case Report

2009 ◽  
Vol 22 (2) ◽  
pp. 279-281
Author(s):  
SM Badruddoza ◽  
S Naz
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Sore Throat ◽  
Male Patient ◽  
Clinical Examination ◽  
Histopathological Examination ◽  
Primary Malignant Melanoma ◽  
Polypoid Mass ◽  
Current Case ◽  
History Of

Malignant melanoma is a neoplasm of melanocytes. Primary malignant melanoma of the oronasal region is rare. When it does occur, it is difficult to manage, and the prognosis is not good. The current case was a 48 years old male patient who presented with history of sore throat, pain in left tonsillar region, hemoptysis with difficulty in swallowing. Clinical examination revealed a blackish ulcerated polypoid mass in the left palatine tonsil. Left sided tonsilectomy was done. Histopathological examination revealed primary malignant melanoma of the tonsil.TAJ 2009; 22(1): 279-281

scholarly journals Primary malignant melanoma of vagina: a case report

2020 ◽  
Vol 9 (8) ◽  
pp. 3499
Author(s):  
Smruti Shambharkar ◽  
Tarachand Sharma
Keyword(s):  
Malignant Melanoma ◽  
Firm Growth ◽  
Histopathological Examination ◽  
Lateral Wall ◽  
Primary Malignant Melanoma ◽  
Malignant Neoplasms ◽  
Vaginal Examination ◽  
Aggressive Disease ◽  
History Of ◽  
Worse Prognosis

Primary malignant melanoma of the vagina is a rare and aggressive disease with worse prognosis as compared with non-genital melanomas or other vaginal malignant neoplasms. Presented here is a case of 42 years female with 3 months history of amenorrhea and vaginal discharge. On vaginal examination, a firm growth of size approximately 7-8 cm was found attached to the left postero-lateral wall of vagina and extending up to the introitus. On biopsy and histopathological examination, it was diagnosed as a case of high-grade malignant melanoma of amelanotic type. Radiotherapy was started as a part of treatment after consultation with an oncologist, considering non-resectable nature of the mass. The patient received first 5 cycles of radiotherapy but succumbed to the disease during treatment.

scholarly journals Case of a Giant Conjunctival Melanocytic Nevus

2020 ◽  
pp. 1-6
Author(s):  
Hidetsugu Mori ◽  
Kanji Takahashi
Keyword(s):  
Malignant Melanoma ◽  
Clinical Diagnosis ◽  
Histopathological Examination ◽  
Melanocytic Nevus ◽  
Immunohistochemical Examination ◽  
Ki 67 ◽  
S 100 ◽  
Hematoxylin Eosin ◽  
Nevus Cell ◽  
Hmb 45

A 78-year-old female experienced extraocular extension of a giant conjunctival melanocytic mass. The clinical diagnosis was conjunctival malignant melanoma. We performed local excision and histopathological examination. The result of hematoxylin-eosin staining disclosed multiple intralesional mucosal cysts and nevus cell nests with abundant melanin. Immunohistochemical examination revealed expression of S-100, melan-A, and HMB-45 and no expression of Ki-67. Histopathological examination showed no evidence of malignancy. Giant conjunctival melanocytic nevi can be diagnostically confused with conjunctival malignant melanoma.

scholarly journals Primary malignant melanoma of the spinal cord: a case report

2016 ◽  
Vol 2 (4) ◽  
pp. 144
Author(s):  
Ashutosh Das Sharma ◽  
Jyoti Poddar ◽  
Ubrangala Suryanarayan Kunikullaya ◽  
Jay Prakash Neema
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Malignant Melanoma ◽  
Primary Malignant Melanoma

scholarly journals Primary Malignant Melanoma of Vagina: A Clinicopathologic Analysis of 6 Cases

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S80-S80
Author(s):  
Y Xiang ◽  
X G Xu ◽  
X Zhang
Keyword(s):  
Malignant Melanoma ◽  
Adjuvant Therapy ◽  
Progression Free Survival ◽  
Primary Malignant Melanoma ◽  
Depth Of Invasion ◽  
Term Survival ◽  
Free Survival ◽  
Pathologic Features ◽  
S 100

Abstract Introduction/Objective Primary malignant melanoma of vagina (PMMV) has a very high rate of recurrence and poor long-term survival. Less than 250 cases are reported in English literature to date, optimal treatments, risk factors, and prognostic predictors for PMMV are still subjects of debate. This study sought to evaluate the clinicopathologic features, initial management, and survival of 6 patients over 7 years follow-up in one institution. Methods/Case Report In this study, the clinical and pathologic features of 6 PMMV occurring in patients age 49 to 83 years were evaluated retrospectively. The mean age of the patients was 68.2 years, and all patients were postmenopausal women. At the time of diagnosis, all tumors were limited to the vagina. Results (if a Case Study enter NA) Vaginal bleeding, discharge and a tumor mass were the chief complaints. These patients were treated by pelvic exenteration, radical surgery and postoperative chemotherapy and/or radiotherapy. Follow-up was available in all patients ranging from 1 to 7 years. Two patients had metastases in other organs died at 16 and 34 months respectively. Two patients had distant recurrence at 1 to 2 years and are still alive. The other 2 patients have no evidence of disease over 2 years follow-up. Grossly, the tumors were mostly polypoid and ranged from 0.25 to 9.5 cm (mean, 5 cm) in maximum dimension. The depth of invasion ranged from 2.2 to 11 mm. A vertical growth phase was present in all tumors. S-100, HMB-45 and Melan-A were positive in 100% of cases tested. Depth of invasion, mitotic index of tumor cells, tumor size, age, menopausal status, pelvic lymph node metastasis and lymphocytic infiltration show no tendency towards progression-free survival. Patients with positive or indeterminate margin status demonstrated a higher risk of recurrence than did patients with negative margins. And adjuvant therapy was associated with progression-free survival. Conclusion In conclusion, PMMV is a rare disease, predominantly seen in women of postmenopausal age, and is associated with a poor prognosis. This study confirms S-100, HMB-45and Melan-A remains the most sensitive marker. Conventional predictors were of no prognostic value. Positive margin and adjuvant therapy were associated with progression-free survival. This report can facilitate the expansion of the phenotypic spectrum of gynecologic melanomas, and contribute to the prevention of misdiagnosis and inadequate treatment of PMMV.

scholarly journals A case of primary malignant melanoma of the esophagogastric junction with abscopal effect after nivolumab administration

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Takahisa Yamaguchi ◽  
Sachio Fushida ◽  
Jun Kinoshita ◽  
Hiroto Saito ◽  
Mari Shimada ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Renal Dysfunction ◽  
Esophagogastric Junction ◽  
Primary Malignant Melanoma ◽  
Pancreatic Metastasis ◽  
Abscopal Effect ◽  
Lower Esophagus ◽  
Long Term Treatment ◽  
Pleural Metastasis ◽  
S 100

Abstract Background The abscopal effect is a rare phenomenon in which local irradiation causes tumor regression outside the irradiated area. There have been no reports of abscopal effect in patients with gastrointestinal melanoma with metastasis. Here, we report a case of primary malignant melanoma of the esophagogastric junction with abscopal effect after long-term treatment with nivolumab. Case presentation A 75-year-old woman was referred to our hospital with a gastroesophageal lesion. Upper gastrointestinal endoscopy revealed a raised lesion on the posterior wall of the greater curvature of the cardia and tenderness in the lower esophagus. Immunostaining of the tumor biopsy showed positive staining for Melan-A, human melanoma black-45 (HMB45), and S-100, indicating malignant melanoma of the esophagogastric junction. Contrast-enhanced computed tomography (CT) of the abdomen showed a mildly stained lesion protruding into the cardiac part of stomach and enlarged surrounding lymph nodes. The patient was diagnosed with malignant melanoma of the esophagogastric junction and proximal gastrectomy with lower esophagus resection was performed. Histological examination showed large, round tumor cells with nuclear atypia. Immunostaining was positive for Melan A, HMB45, S-100 protein, and SRY-box transcription factor 10, and the final diagnosis was malignant melanoma of the esophagogastric junction, with regional lymph node metastases. Three months after surgery, follow-up CT indicated left pleural metastasis; therefore, the patient was administered nivolumab, an immune checkpoint inhibitor (ICI). Following three courses of nivolumab, the patient exhibited grade 3 renal dysfunction (Common Terminology Criteria for Adverse Events version 5.0). After that, we have not administered nivolumab treatment. Five months after the development of renal dysfunction, a CT scan demonstrated an unstained nodule within the pancreatic, and the patient was diagnosed with pancreatic metastasis; intensity-modulated radiotherapy was performed. Six months later, CT revealed pancreatic nodule and pleural metastasis was shrunk; after an additional 2 months, pleural metastasis and effusion had disappeared. The patient is alive with no additional lesions. Conclusions We report a case of primary malignant melanoma of the esophagogastric junction with an abscopal effect following nivolumab treatment. The findings of this case report suggest that ICIs in combination with radiotherapy may be effective for treating metastatic or recurrent malignant melanoma of the gastrointestinal tract.

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