scholarly journals Conservative management of primary malignant melanoma of the bladder: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Sebastiano Rapisarda ◽  
Maida Bada ◽  
Andrea Polara ◽  
Felice Crocetto ◽  
Massimiliano Creta ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Bladder Tumor ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Clinical History ◽  
Metastatic Malignant Melanoma ◽  
Primary Malignant Melanoma ◽  
Bacillus Calmette Guerin ◽  
Endoscopic Evaluation ◽  
Case Presentation

Abstract Background Primary malignant melanoma (PMM) of the bladder represents a very rare clinic-pathologic entity. Given the rarity of the disease, the best treatment option is not well recognized. Case presentation We describe a case of neoplasm of the bladder in a 74 years-old Caucasian man presenting with massive hematuria. Based on clinical, instrumental and histological findings a diagnosis of PMM was made. The patient underwent trans urethral resection of bladder tumor plus intravesical Bacillus Calmette–Guérin. Conclusions To make a correct diagnosis, clinical history, endoscopic evaluation, histopathological examination and immunohistochemistry, are necessary. Multidisciplinary evaluation is required to discriminate primary from metastatic malignant melanoma.

scholarly journals Primary Spinal Cord Melanoma of Intradural Extramedullary Origin

2019 ◽  
Vol 10 (03) ◽  
pp. 522-525
Author(s):  
Ashish Sharma ◽  
Virendra Deo Sinha
Keyword(s):  
Spinal Cord ◽  
Malignant Melanoma ◽  
Histopathological Examination ◽  
Lower Limbs ◽  
Primary Malignant Melanoma ◽  
Magnetic Resonance Imaging Scan ◽  
Lumbosacral Region ◽  
Intensity Lesion ◽  
S 100 ◽  
L1 And L2

AbstractPrimary malignant melanoma is the very rare entity of the central nervous system. It accounts only 1% of all melanoma cases. A 67-year-old patient presented to us with lower back pain radiating to the left lower limb and progressive weakness of both lower limbs. She underwent magnetic resonance imaging scan of lumbosacral region that suggested T1 hyperintense, T2 hypointense, extramedullary altered signal intensity lesion at L1 and L2 vertebral level compressing terminal spinal cord, and cauda equine region. On histopathological examination, findings were suggestive of malignant melanoma that was confirmed with immunohistochemistry examination (positive for S-100, Melan-A, and HMB-45). Here, we are discussing an unusual case of primary malignant melanoma of conus and cauda equine region with comprehensive review regarding management and prognosis of the tumor.

scholarly journals Primary Malignant Melanoma of the Tonsil : A Case Report

2009 ◽  
Vol 22 (2) ◽  
pp. 279-281
Author(s):  
SM Badruddoza ◽  
S Naz
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Sore Throat ◽  
Male Patient ◽  
Clinical Examination ◽  
Histopathological Examination ◽  
Primary Malignant Melanoma ◽  
Polypoid Mass ◽  
Current Case ◽  
History Of

Malignant melanoma is a neoplasm of melanocytes. Primary malignant melanoma of the oronasal region is rare. When it does occur, it is difficult to manage, and the prognosis is not good. The current case was a 48 years old male patient who presented with history of sore throat, pain in left tonsillar region, hemoptysis with difficulty in swallowing. Clinical examination revealed a blackish ulcerated polypoid mass in the left palatine tonsil. Left sided tonsilectomy was done. Histopathological examination revealed primary malignant melanoma of the tonsil.TAJ 2009; 22(1): 279-281

scholarly journals Primary malignant melanoma of vagina: a case report

2020 ◽  
Vol 9 (8) ◽  
pp. 3499
Author(s):  
Smruti Shambharkar ◽  
Tarachand Sharma
Keyword(s):  
Malignant Melanoma ◽  
Firm Growth ◽  
Histopathological Examination ◽  
Lateral Wall ◽  
Primary Malignant Melanoma ◽  
Malignant Neoplasms ◽  
Vaginal Examination ◽  
Aggressive Disease ◽  
History Of ◽  
Worse Prognosis

Primary malignant melanoma of the vagina is a rare and aggressive disease with worse prognosis as compared with non-genital melanomas or other vaginal malignant neoplasms. Presented here is a case of 42 years female with 3 months history of amenorrhea and vaginal discharge. On vaginal examination, a firm growth of size approximately 7-8 cm was found attached to the left postero-lateral wall of vagina and extending up to the introitus. On biopsy and histopathological examination, it was diagnosed as a case of high-grade malignant melanoma of amelanotic type. Radiotherapy was started as a part of treatment after consultation with an oncologist, considering non-resectable nature of the mass. The patient received first 5 cycles of radiotherapy but succumbed to the disease during treatment.

Metastatic Malignant Melanoma in Prepubertal Children

PEDIATRICS ◽  
1975 ◽  
Vol 55 (2) ◽  
pp. 191-204
Author(s):  
Daniel J. Trozak ◽  
Willard D. Rowland ◽  
Funan Hu
Keyword(s):  
Malignant Melanoma ◽  
Metastatic Melanoma ◽  
Correct Diagnosis ◽  
Metastatic Malignant Melanoma ◽  
Epithelioid Cell ◽  
Low Grade ◽  
Microscopic Appearance ◽  
Malignant Melanomas ◽  
Real Nature ◽  
Benign Nevi

Medical literature is full of involved and Confusing reports on the genesis, incidence, and development of metastatic melanoma in children. The reason for this confusion can be found in the early uncertainties that surrounded the real nature and correct diagnosis of metastatic melanoma in the prepubertal child. Before 1950, reports of melanomas with metastases in children were rare, poorly documented, and in many cases erroneous.1-4 In particular, benign nevi (now known as benign juvenile melanoma) went unrecognized and because of their alarming microscopic features were often diagnosed as malignant melanomas. For example, deceived by the predilection of this nevus for childhood, its frightening appearance, and failure to metastasize, Pack and Anglem wrote: ". . . . although malignant melanomas are found in infancy and childhood, they are of low grade malignancy and seldom metastasize" In a later paper, Pack6 coined the term "prepubertal melanoma" for those nonmetastasizing pigmented tumors of children which were microscopically indistinguishable from melanoma. He suggested removal before puberty when endocrinologic stimulation rendered certain of them capable of metastasis. Other investigators also noted this seeming disparity between microscopic appearance and clinical behavior.7 In 1948, Spitz8 provided the criteria for separating this unusual-looking nevus from malignant melanoma and termed it "juvenile melanoma." Later she and Allen9 showed that although these lesions are not restricted to children, they are much more common before puberty.* Subsequent authors10-13 have also classified juvenile melanoma among the benign nevi and the term spindle or epithelioid cell nevus10,12,13 is now preferred. McWhorter and Woolner13 in 1954 reviewed the subject of malignant melanoma in children and suggested that the favorable prognosis was spurious and due to the erroneous classification of spindle and epithelioid cell nevi under the former agnosis.

scholarly journals Metastasis of Malignant Melanoma to Urinary Bladder: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Rashna Meunier ◽  
Gyan Pareek ◽  
Ali Amin
Keyword(s):  
Differential Diagnosis ◽  
Malignant Melanoma ◽  
Urinary Bladder ◽  
Clinical History ◽  
Metastatic Malignant Melanoma ◽  
Review Of The Literature ◽  
Bladder Mucosa ◽  
Immunohistochemical Examination ◽  
History Of ◽  
The Right

Aims. Metastatic malignant melanoma of the urinary bladder is a rare clinical entity, with only twenty-three published cases to date. We present a case of this rare entity, a thorough review of the literature, and differential diagnosis of melanoma in the bladder.Methods and Results. A 55-year-old woman with a history of malignant melanoma of the right thigh, excised eight years ago, presented with back pain, fatigue, and hematuria. She underwent computed tomography (CT) scan and was found to have metastases within the liver, spleen, lungs, and urinary bladder. She underwent cystoscopy and transurethral resection of three polypoid lesions. Histologic and immunohistochemical examination revealed metastatic malignant melanoma involving bladder mucosa.Conclusions. This case illustrates the importance of including malignant melanoma in the differential diagnosis of high grade neoplasms of bladder, especially in cases where the relevant clinical history is not available.

scholarly journals Primary Malignant Melanoma of the Urinary Bladder

2011 ◽  
Vol 2011 ◽  
pp. 1-2 ◽  
Author(s):  
Jalal Eddine El Ammari ◽  
Youness Ahallal ◽  
Mohammed Jamal El Fassi ◽  
Moulay Hassan Farih
Keyword(s):  
Malignant Melanoma ◽  
Urinary Bladder ◽  
Male Patient ◽  
Metastatic Disease ◽  
Transurethral Resection ◽  
Bladder Tumor ◽  
Case Reports ◽  
Primary Melanoma ◽  
Case Presentation ◽  
History Of

Introduction. Primary melanoma of the urinary bladder is very rare. As far as we know, 19 cases have been reported worldwide, usually as case reports.Case Presentation. We present a 71-year-old male patient presented with a 2-month history of hematuria. Ultrasonography revealed a 5-cm-size mass located in the bladder trigone. A transurethral resection of the bladder tumor (TURBT) revealed a malignant melanoma. Evaluation for metastatic disease was negative. The patient deceased five months later before radical treatment could be performed.Conclusion. This is one more reported case of primary melanoma of the urinary bladder. The previously reported cases of bladder melanoma are reviewed. Therapy and prognosis are discussed.

scholarly journals Primary Angiosarcoma of the Spleen: An Oncological Enigma

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Myoteri Despoina ◽  
Dellaportas Dionysios ◽  
Ayiomamitis Georgios ◽  
Strigklis Konstantinos ◽  
Kouroumpas Efstratios ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Abdominal Mass ◽  
Correct Diagnosis ◽  
Histopathological Diagnosis ◽  
Case Presentation ◽  
Male Predominance ◽  
Primary Angiosarcoma ◽  
Left Pleural Effusion ◽  
Disease Site ◽  
Splenic Angiosarcoma

Introduction. Primary splenic angiosarcoma is an extremely unusual neoplasm originating from sinusoidal vascular endothelium. Surgical extirpation is the mainstay of treatment of this highly malignant disease.Case Presentation. An 82-year-old woman was admitted with left pleural effusion and a palpable left upper quadrant abdominal mass, secondary to splenomegaly by two large splenic tumors. Classic open splenectomy was performed and angiosarcoma of the spleen was the final histopathological diagnosis, which was primary since no other disease site was revealed.Discussion. The incidence of the disease is 0.14–0.23 cases per million, with slight male predominance. Etiology is not established and clinical presentation may confuse even experienced physicians. Imaging modalities cannot differentiate the lesion from other vascular splenic neoplasms and the correct diagnosis is mainly set after histopathological examination of the resected spleen. As with other sarcomas, surgery is the only curative approach, while chemo- and radiotherapy have poor results. Prognosis remains dismal.

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