scholarly journals A rare case of progressive disseminated histoplasmosis with bone marrow involvement in an immunocompetent patient

2017 ◽  
Vol 5 (10) ◽  
pp. 4636
Author(s):  
Subodh K. Mahto ◽  
Pulin K. Gupta ◽  
Sahil Sareen ◽  
Arjun M. Balakrishna ◽  
Sumit K. Suman
Keyword(s):  
Rare Case ◽  
West Bengal ◽  
Bone Marrow Involvement ◽  
Immunocompetent Patient ◽  
Eastern Region ◽  
Rare Entity ◽  
Endemic Region ◽  
Immunocompetent Individual ◽  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis

Histoplasmosis is a rare entity in India and very few cases have been reported from eastern region of India like West Bengal and rarely cases from southern India as well. We hereby report a case of progressive disseminated histoplasmosis (PDH) from a non-endemic region of India (Eastern Utter Pradesh) and that too in an immunocompetent individual. 

scholarly journals Typical Facial Lesions: A Window of Suspicion for Progressive Disseminated Histoplasmosis—A Case of Asian Prototype

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Prasan K. Panda ◽  
Siddharth Jain ◽  
Rita Sood ◽  
Rajni Yadav ◽  
Naval K. Vikram
Keyword(s):  
Histoplasma Capsulatum ◽  
Bone Marrow Aspiration ◽  
Febrile Illness ◽  
Immunocompetent Patient ◽  
Dimorphic Fungus ◽  
Recent Onset ◽  
Disseminated Histoplasmosis ◽  
The Face ◽  
History Of ◽  
Progressive Disseminated Histoplasmosis

Histoplasmosis is caused by a dimorphic fungusHistoplasma capsulatumin endemic areas, mainly America, Africa, and Asia. In India, it is being reported from most states; however, it is endemic along the Ganges belt. We report a case of an apparently immunocompetent male who presented with 3-month history of fever, cough, and weight loss with recent onset odynophagia and had hepatosplenomegaly and mucocutaneous lesions over the face. The differential diagnosis of leishmaniasis, tuberculosis, leprosy, fungal infection, lymphoproliferative malignancy, and other granulomatous disorders was considered, but he succumbed to his illness. Antemortem skin biopsy and bone marrow aspiration along with postmortem liver, lung, and spleen biopsy showed disseminated histoplasmosis. This case highlights the need for an early suspicion of progressive disseminated histoplasmosis in the presence of classical mucocutaneous lesions even in an immunocompetent patient suffering from a febrile illness. Cure rate approaches almost 100% with early treatment, whereas it is universally fatal if left untreated.

scholarly journals Cryptococcus neoformans infection in a post-operative mastoid cavity of an immunocompetent individual: a rare case report

2020 ◽  
Vol 6 (7) ◽  
pp. 1393
Author(s):  
Rahul S. Gosavi ◽  
Akash D. Gupta ◽  
Shishir D. Gosavi ◽  
Jayanti U. Phatak
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Immunocompetent Patient ◽  
Mastoid Cavity ◽  
Radical Mastoidectomy ◽  
Delay In Diagnosis ◽  
Immunocompetent Individual ◽  
Modified Radical Mastoidectomy ◽  
Rare Case Report ◽  
Medical Line

<p class="abstract">This is a case report of isolated cryptococcosis in the operated mastoid cavity of an immunocompetent individual. A 24 year old immunocompetent male who underwent modified radical mastoidectomy presented to the OPD with complaints of otalgia and recurrent otorrhoea, not responding to regular medical line of treatment and aural toileting. Microscopy and culture of the ear dischrage revealed <em>Cryptococcus</em> <em>neoformans</em>. The patient was treated with oral and topical fluconazole and recovered completely. Although rare, cryptococcal mastoiditis should be considered even in an immunocompetent patient, as any delay in diagnosis and treatment can lead to fatal complications.</p>

scholarly journals Histoplasmosis Diagnosed in Europe and Israel: A Case Report and Systematic Review of the Literature from 2005 to 2020

2021 ◽  
Vol 7 (6) ◽  
pp. 481
Author(s):  
Spinello Antinori ◽  
Andrea Giacomelli ◽  
Mario Corbellino ◽  
Alessandro Torre ◽  
Marco Schiuma ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hiv Infection ◽  
Histoplasma Capsulatum ◽  
People Living With Hiv ◽  
Immunocompromised Patients ◽  
Dimorphic Fungus ◽  
Endemic Region ◽  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis ◽  
Living With Hiv

Human histoplasmosis is a mycosis caused by two distinct varieties of a dimorphic fungus: Histoplasma capsulatum var. capsulatum and H. capsulatum var. duboisii. In Europe, it is usually imported by migrants and travellers, although there have been some autochthonous cases, especially in Italy; however, most European physicians are unfamiliar with its clinical and pathological picture, particularly among immunocompromised patients without HIV infection. This systematic review of all the cases of histoplasmosis reported in Europe and Israel between 2005 and 2020 identified 728 cases diagnosed in 17 European countries and Israel described in 133 articles. The vast majority were imported (mainly from Central and South America), but there were also seven autochthonous cases (six in Europe and one in Israel). The patients were prevalently males (60.4%), and their ages ranged from 2 to 86 years. The time between leaving an endemic region and the diagnosis of histoplasmosis varied from a few weeks to more than 40 years. Progressive disseminated histoplasmosis was the most frequent clinical picture among people living with HIV infection (89.5%) or a different immunocompromising condition (57.1%), but it was also recorded in 6.2% of immunocompetent patients. Twenty-eight cases were caused by Histoplasma duboisii. Immunocompromised patients without HIV infection had the worst outcomes, with a mortality rate of 32%.

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