Progressive disseminated histoplasmosis in an apparently immunocompetent patient with a bioprosthetic aortic valve

2020 ◽  
Vol 5 (1) ◽  
pp. 49-52
Author(s):  
Anthony Lieu ◽  
Leighanne O Parkes ◽  
Yves Longtin ◽  
Karl Weiss ◽  
Gerasimos J Zaharatos
Keyword(s):  
Aortic Valve ◽  
Immunocompetent Patient ◽  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis

scholarly journals Typical Facial Lesions: A Window of Suspicion for Progressive Disseminated Histoplasmosis—A Case of Asian Prototype

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Prasan K. Panda ◽  
Siddharth Jain ◽  
Rita Sood ◽  
Rajni Yadav ◽  
Naval K. Vikram
Keyword(s):  
Histoplasma Capsulatum ◽  
Bone Marrow Aspiration ◽  
Febrile Illness ◽  
Immunocompetent Patient ◽  
Dimorphic Fungus ◽  
Recent Onset ◽  
Disseminated Histoplasmosis ◽  
The Face ◽  
History Of ◽  
Progressive Disseminated Histoplasmosis

Histoplasmosis is caused by a dimorphic fungusHistoplasma capsulatumin endemic areas, mainly America, Africa, and Asia. In India, it is being reported from most states; however, it is endemic along the Ganges belt. We report a case of an apparently immunocompetent male who presented with 3-month history of fever, cough, and weight loss with recent onset odynophagia and had hepatosplenomegaly and mucocutaneous lesions over the face. The differential diagnosis of leishmaniasis, tuberculosis, leprosy, fungal infection, lymphoproliferative malignancy, and other granulomatous disorders was considered, but he succumbed to his illness. Antemortem skin biopsy and bone marrow aspiration along with postmortem liver, lung, and spleen biopsy showed disseminated histoplasmosis. This case highlights the need for an early suspicion of progressive disseminated histoplasmosis in the presence of classical mucocutaneous lesions even in an immunocompetent patient suffering from a febrile illness. Cure rate approaches almost 100% with early treatment, whereas it is universally fatal if left untreated.

scholarly journals A rare case of progressive disseminated histoplasmosis with bone marrow involvement in an immunocompetent patient

2017 ◽  
Vol 5 (10) ◽  
pp. 4636
Author(s):  
Subodh K. Mahto ◽  
Pulin K. Gupta ◽  
Sahil Sareen ◽  
Arjun M. Balakrishna ◽  
Sumit K. Suman
Keyword(s):  
Rare Case ◽  
West Bengal ◽  
Bone Marrow Involvement ◽  
Immunocompetent Patient ◽  
Eastern Region ◽  
Rare Entity ◽  
Endemic Region ◽  
Immunocompetent Individual ◽  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis

Histoplasmosis is a rare entity in India and very few cases have been reported from eastern region of India like West Bengal and rarely cases from southern India as well. We hereby report a case of progressive disseminated histoplasmosis (PDH) from a non-endemic region of India (Eastern Utter Pradesh) and that too in an immunocompetent individual. 

scholarly journals Subacute progressive disseminated histoplasmosis in immunocompetent patient

2016 ◽  
Vol 31 (5) ◽  
pp. 999-1002 ◽  
Author(s):  
Seong Jin Choi ◽  
Han-Sol Choi ◽  
June Young Chun ◽  
Chung-Jong Kim ◽  
Myung Jin Lee ◽  
...  
Keyword(s):  
Immunocompetent Patient ◽  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis

Candida albicans endocarditis involving a normal native aortic valve in an immunocompetent patient

2020 ◽  
Vol 13 (11) ◽  
pp. e236902
Author(s):  
Taha Sheikh ◽  
Jeremy C Tomcho ◽  
Mohammed T Awad ◽  
Syeda Ramsha Zaidi
Keyword(s):  
Candida Albicans ◽  
Mortality Rate ◽  
Aortic Valve ◽  
High Mortality ◽  
Treatment Options ◽  
Immunocompetent Patient ◽  
Fungal Endocarditis ◽  
Appropriate Treatment ◽  
Mechanical Valves ◽  
Serious Infection

Fungal endocarditis, specifically from Candida species, is a rare but serious infection with a high mortality rate. Most cases occur in bioprosthetic or mechanical valves and are uncommon in native, structurally normal valves. When Candida endocarditis is detected and appropriate treatment is initiated earlier, there is an improvement in mortality. While the recommendation is usually to treat with a combination of surgery and antifungal medications, patient comorbidities may limit treatment options.

scholarly journals Gastrointestinal Histoplasmosis Mimicking Crohn’s Disease

2021 ◽  
Author(s):  
Esfandiar Shojaei ◽  
Joanna C Walsh ◽  
Nikhil Sangle ◽  
Brian Yan ◽  
Michael S Silverman ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Antifungal Therapy ◽  
Immunocompetent Patient ◽  
Immunocompromised Patients ◽  
Disseminated Histoplasmosis ◽  
Gastrointestinal Histoplasmosis ◽  
Life Threatening ◽  
Inflammatory Drugs ◽  
Tissue Specimens

Abstract Disseminated histoplasmosis is a life-threatening disease usually seen in immunocompromised patients living in endemic areas. We present an apparently immunocompetent patient with gastrointestinal histoplasmosis who was initially diagnosed as biopsy-proven Crohn’s disease. Following discontinuation of anti-inflammatory drugs and institution of antifungal therapy, his GI illness completely improved. Specific fungal staining should be routinely included in histopathologic assessment of tissue specimens diagnosed as Crohn’s disease.

Treatment Of Disseminated Histoplasmosis With Ethyl Vanillate

PEDIATRICS ◽  
1951 ◽  
Vol 7 (1) ◽  
pp. 7-18
Author(s):  
AMOS CHRISTIE ◽  
JAMES G. MIDDLETON ◽  
J. CYRIL PETERSON ◽  
DAVID L. MCVICKAR
Keyword(s):  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis

Some of the physical and pharmacologic properties of ethyl vanillate, a new fungistatic or fungicidal agent, have been briefly stated. The records of 12 patients with progressive disseminated histoplasmosis treated with ethyl vanillate have been reviewed. Five of these patients are alive and apparently well following treatment, an experience not previously encountered or reported in the literature. The use of the drug in the treatment of histoplasmosis has been outlined and the toxic manifestations of overdosage have been described.

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