Determination of anti-streptolysin – O titer in suspected cases of streptococcal infection

2021 ◽  
Vol 7 (4) ◽  
pp. 279-282
Author(s):  
Shweta R Sharma ◽  
Rounak Chahal ◽  
Anshuman Srivastava ◽  
Umar Farooq ◽  
Sudhir Singh ◽  
...  
Keyword(s):  
Streptococcal Infection ◽  
Early Stage ◽  
Research Centre ◽  
Blood Samples ◽  
Hemolytic Streptococcus ◽  
Streptolysin O ◽  
Beta Hemolytic Streptococcus ◽  
Group A ◽  
Infective Agent

The Group A beta hemolytic streptococcus has remained a major human infective agent for hundreds of years. Group 'A' beta hemolytic streptococcus related ailment and sequelae keep on affecting general public and national economy as they mostly influence kids and youthful grown-ups. Current research aimed to determination of anti-streptolysin –o titer in suspected cases of streptococcal infection. : Determination of anti-Streptolysin-O (ASO) titer in suspected cases of streptococcal infection. The measurement of ASO levels was done by semi-quantitative analyzer analyzer on photometric and colorimetric systems. 107 blood samples were taken in our study. This study was conduct in serological section of microbiology department of Teerthanker Mahaveer Hospital & research centre Moradabad. A total 107 samples were tested in this study. Of these, 23(21.5%) were found to be positive for the presence of ASO having titre of >200IU/mL. This study will be useful to evaluate utility of sero-diagnosis in our catering population and found useful in early diagnosis and treatment of these pathogens. Treatment can be initiated at an early stage leading to reduction in complications and associated mortality.

scholarly journals Pediatric autoimmune neuropsychiatric disorder associated with Streptococcal infection (PANDAS syndrome): real-world practice and clinical case

2019 ◽  
Vol 18 (3) ◽  
pp. 53-56
Author(s):  
T. L. Uspenskaya ◽  
T. V. Vinogradova ◽  
S. L. Ipatova ◽  
E. P. Sitnikova ◽  
D. S. Kasatkin
Keyword(s):  
Brain Damage ◽  
Real World ◽  
Clinical Case ◽  
Streptococcal Infection ◽  
Infectious Agents ◽  
Hemolytic Streptococcus ◽  
Cross Reactions ◽  
Direct Damage ◽  
Beta Hemolytic Streptococcus ◽  
Group A

Group A beta-hemolytic streptococcus is one of the most important infectious agents leading to both direct damage to organs, and to various cross-reactions with body antigens. One of these forms, manifested by the defeat of subcortical ganglia, is PANDAS syndrome. This paper describes the international criteria and clarifies the differences between this disorder and other forms of brain damage. Paper also describes the clinical case of PANDAS syndrome in a 7-year-old child.

scholarly journals Prevalence of Group A Beta-Hemolytic Streptococcus Oropharyngeal Colonization in Children and Therapeutic Regimen Based on Antistreptolysin Levels: Data from a City From Southern Brazil

2014 ◽  
Vol 8 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Alexandre B Merlini ◽  
Carolina S Stocco ◽  
Marcelo D Schafranski ◽  
Polliane Arruda ◽  
Larissa Bail ◽  
...  
Keyword(s):  
Roc Curve ◽  
Serological Test ◽  
Pediatric Population ◽  
Southern Brazil ◽  
Chi Square ◽  
Hemolytic Streptococcus ◽  
Beta Hemolytic Streptococcus ◽  
Group A ◽  
Rheumatic Heart

The aim of this study is to determinate the prevalence of oropharyngeal colonization by group A beta-hemolytic Streptococcus (GABHS) in pediatric population of Ponta Grossa, a midsize city of southern Brazil; estimate the effectiveness of antistreptolysin-O (ASO), compared to culture, in presence of infection; and design an unpublished investigative algorithm of rheumatic fever's suspicion, based on needs identified in worldwide consensus. It is an epidemiologic, observational and transversal study, involving 180 children younger than 12 years. Secretion of posterior oropharynx was collected for culture; and peripheral blood for determination of ASO. Student-t and chi-square tests, with Yates correction, were performed for statistical analysis. The ASO cutoff was determined by Receiver Operating Characteristic (ROC) curve. The prevalence encountered was 3.9%, and 25.5% of the children showed reagent ASO. This serological test demonstrated quantitatively and qualitatively significant associations to the GABHS presence (p=0.0001 for both associations) throughout the ROC curve, 200 U Todd was the value that resulted in the best accuracy, demonstrating 100% of sensibility and 80% of specificity in the GAS infection documentation. Also, it was found that the value of 1.200 U represents a specificity of 100%. The results emphasize the need for similar studies in other populations, to provide better targeting of the diagnosis and treatment of oropharyngitis by GABHS, which in turn can prevent up to 80% the cases of rheumatic fever, and consequently, the chronic rheumatic heart disease.

A group A beta-hemolytic streptococcus: actual problems of the present and prospects of its solution

2015 ◽  
pp. 32-36 ◽  
Author(s):  
L.S. Ovcharenko ◽  
◽  
A.A. Vertegel ◽  
T.G. Andrienko ◽  
N.V. Zhikhareva ◽  
...  
Keyword(s):  
Hemolytic Streptococcus ◽  
Beta Hemolytic Streptococcus ◽  
Group A

Group A β-Hemolytic Streptococcal Balanitis: It May Be More Common Than You Think

PEDIATRICS ◽  
1991 ◽  
Vol 88 (1) ◽  
pp. 154-156
Author(s):  
NICHOLAS C. KYRIAZI ◽  
CYNTHIA L. COSTENBADER
Keyword(s):  
Sexual Abuse ◽  
Streptococcal Infection ◽  
Hemolytic Streptococcus ◽  
Depth Study ◽  
Group A

Group A β-hemolytic Streptococcus can cause balanitis in prepubertal males, and its incidence is probably greater than previously reported in the pediatric literature. We suggest the routine inclusion of a GABHS-selective culture in any case where a discharge or irritation is present on the glans or foreskin, especially if a recent streptococcal infection has been documented, whether on not sexual abuse is being considered. Finally, we hope to stimulate interest for further in-depth study of balanitis caused by GABHS.

Severe Peritonitis during CAPD Due to Beta-hemolytic Streptococcus, Lancefield Group A

1983 ◽  
Vol 3 (2) ◽  
pp. 109-109 ◽  
Author(s):  
C. Dadone ◽  
L. Bonoldi ◽  
G. Giltri ◽  
L. Vigore ◽  
P. Mariani ◽  
...  
Keyword(s):  
Hemolytic Streptococcus ◽  
Beta Hemolytic Streptococcus ◽  
Severe Peritonitis ◽  
Group A ◽  
Lancefield Group
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