scholarly journals Ki67 and P53 expression in breast cancer and their correlation with clinicopathological parameters

2021 ◽  
Vol 8 (4) ◽  
pp. 478-484
Author(s):  
Sukanya Gogoi ◽  
Bandita Das ◽  
Mondita Borgohain ◽  
Gayatri Gogoi ◽  
Jayanta Das
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Menopausal Status ◽  
Clinicopathological Parameters ◽  
Lymph Node Status ◽  
P Value ◽  
Axillary Lymph ◽  
Ki 67 ◽  
P53 Expression ◽  
Node Status

Breast carcinoma is the most common malignancy in females and is a leading cause of death. Treatment depends upon various pathological and prognostic markers like lymph node status, size, type and grade of the tumour which influences the outcome of breast cancer. Markers like Ki-67 and p53 have been studied extensively and their roles in breast cancer are yet to be established.We evaluated the expression of Ki67 and P53 in breast cancer and their association with other clinico-pathological factors was studied. Ki67 and P53 expression was assessed in 60 breast cancer cases admitted to our hospital over a period of one year. Association with other prognostic parameters was evaluated. Statistical analysis was done by Chi square test and a p value of <0.05 was taken as significant. 43.33% cases had low proliferative Ki-67 score whereas 56.67% of the cases were highly proliferative. p53 expression was seen in 41.66% cases. Ki-67 and p53 expression were not significantly related to age, menopausal status, and tumour size whereas a significant correlation was seen with positive axillary lymph node status, high histological grade, negative hormone receptor status (ER, PR) and positive HER2/neu expression. Significant association was seen between Ki-67 and p53 expression.Ki67 and P53 may be considered as a valuable biomarker in breast cancer patients which can help in planning treatment strategies.

Expression of CXCR4 is associated with axillary lymph node status in patients with early breast cancer

The Breast ◽  
2006 ◽  
Vol 15 (4) ◽  
pp. 533-539 ◽  
Author(s):  
Y.-C. Su ◽  
M.-T. Wu ◽  
C.-J. Huang ◽  
M.-F. Hou ◽  
S.-F. Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Early Breast Cancer ◽  
Axillary Lymph Node ◽  
Lymph Node Status ◽  
Axillary Lymph ◽  
Axillary Lymph Node Status ◽  
Node Status

MRI‐based predictive factors of axillary lymph node status in breast cancer

2020 ◽  
Vol 26 (11) ◽  
pp. 2177-2182 ◽  
Author(s):  
David Atallah ◽  
Malak Moubarak ◽  
Wissam Arab ◽  
Nadine El Kassis ◽  
Georges Chahine ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Predictive Factors ◽  
Axillary Lymph Node ◽  
Lymph Node Status ◽  
Axillary Lymph ◽  
Axillary Lymph Node Status ◽  
Node Status

Age is not a prognostic factor in Korean women with breast cancer treated with breast conservative surgery and radiotherapy

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10740-10740
Author(s):  
D. Choi ◽  
E. Kim ◽  
Y. Kim ◽  
M. Lee ◽  
H. Park
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Lymph Node Metastasis ◽  
Lymph Node Status ◽  
Significant Prognostic Factor ◽  
Axillary Lymph ◽  
Korean Women ◽  
Node Metastasis ◽  
Node Status

10740 Background: The median age of the breast cancer at diagnosis in Korean women is 45 years and a quarter of the patients are at age 40 or younger. The purpose of this study was to analyze the prognostic factors including age for patients treated with breast conserving surgery and radiotherapy. Methods: Two hundred and eleven breast cancer patients were treated with breast conserving therapy at Soonchunhyang University Hospital, Seoul, Korea, between May 1991 and May 2003. The radiation dose to the whole breast was 50.4 Gy over 5 weeks and boost doses of 10–14 Gy administered to the tumor bed in the majority of the patients (180/211). Nodal radiotherapy was delivered in patients with 4 or more node metastasis. Adjuvant chemotherapy was performed in most of the patients with node metastasis or tumors larger than 1cm, or younger patients. One hundred and thirty four patients received CMF regimen, 14 patients treated with CEF regimen. The median and minimum follow-up periods were 58 and 30 months respectively. Results: The average age at the time of operation was 41.9 years (median 42 years, range 23–67 years), and the mean tumor size was 2.03 cm (median 1.80 cm). One hundred and forty seven patients (69.7%) had pathologically node negative disease and fifteen patients had 4 or more lymph node metastasis. Local, regional relapse and distant metastasis occurred in 7, 3 and 10 patients respectively. The 5 year disease free, loco-regional relapse free and overall survival rate were 89.5%, 93.4%, 95.6%, respectively. Three patients among the 31 patients who received 50.4Gy or incomplete radiotherapy to the breast experienced loco-regional relapse. Age (40 years or less versus more than 40 years old) was not a prognostic factor in univariate analysis. T stage (p = 0.027), lymph node metastasis (p < 0.01) were significant factors for recurrences. By multivariate analysis, only lymph node status was a significant prognostic factor for treatment related failure. Conclusions: A breast conserving procedure is effective for patients with early stage breast cancer regardless of age in Korean women. Axillary lymph node status was the most important independent predictor for a recurrence, and more efficient treatment is required for these patients with lymph node metastasis. No significant financial relationships to disclose.

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