Background: Platelets are the richest source for cytokine and growth factors which are two important components of regeneration and Platelet
Rich Fibrin (PRF) has gained popularity in the past two decades. PRF and bioactive glass (BG) have shown effective results in the reduction of
Probing pocket depth (PPD), Gain in clinical attachment level (CAL) and defect ll in intrabony defects.
Materials and Methods: Electronic searches were performed in PubMed, MEDLINE, Cochrane Library, Google Scholar and EbscoHost for the
identication of relevant studies, till 30 September 2020 in English language. Additionally, hand search was also carried out in the relevant
journals. The review protocol followed the PRISMA guidelines and was registered in PROSPERO (CRD42020211755). The risk of bias of the
studies was independently evaluated using Cochrane Risk of Bias tool.
Results: Five RCTs were included, which investigated the effects of PRF as an adjunct to bioactive glass comparing with Bioactive glass alone in
the treatment of intrabony defects. In all the included studies it was found that PRF as adjunct had better results in the outcomes measured when
compared with Bioactive glass alone.
Conclusion: The current review has shown evidence suggesting that platelet rich brin can prove to be effective as a regenerative material, for the
treatment of intrabony defects, in combination with bioactive glass.
Clinical Efficacy of Bioactive Glass in Combination with Platelet Rich Fibrin in Management of Gingival Recession Defects: A Prospective Comparative Study
