scholarly journals A Study of Patterns of Breast Lesions Diagnosed on Fine-Needle Aspiration Cytology in a Tertiary Care Hospital of Mandya

2021 ◽  
Vol 8 (10) ◽  
pp. 562-566
Author(s):  
Mallegowdanadoddi Siddegowda ◽  
Tahniyat Ara
Keyword(s):  
Ductal Carcinoma ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Benign Lesions ◽  
Breast Lump ◽  
Aspiration Cytology ◽  
Not Otherwise Specified ◽  
Infiltrating Ductal Carcinoma ◽  
Malignant Lesions ◽  
Needle Aspiration Cytology

BACKGROUND Breast lump is fairly a common complaint in females for which patient seeks medical advice and becomes anxious about the diagnosis. Quick diagnosis by fineneedle aspiration cytology (FNAC) relieves patient’s anxiety and assists in their preoperative management and overall treatment. This study was conducted to find out the cytomorphological patterns and distribution of breast lesions in various age groups in our institute. METHODS This is a prospective observational study of breast lesions conducted in the Mandya Institute of Medical Sciences, Mandya, for a period of 18 months from January 2016 to June 2017. About 200 cases were studied by cytology and correlated with histopathology wherever biopsy specimens were available, and were stained with haematoxylin and eosin (H & E) and May–Grunwald–Giemsa stains (MGG). Cases were grouped according to the five-tier reporting format for breast lesion (C1 – C5) laid down by National Cancer Institute. RESULTS The spectrum of breast lesions on cytomorphological interpretation was 1 % inadequate / insufficient material (C1), 80 % benign (C2), 1.5 % atypia probably benign (C3), 0.5 % suspicious of malignancy (C4) and 17 % malignant (C5). Out of 200 cases studied, 160 cases were benign lesions, and 34 cases were malignant lesions. Most of the benign lesions belonged to the age group 21 - 30 years followed by 31 - 40 years. Malignant lesions were maximum in the age group of 41 - 50 years. In benign disease, fibroadenoma was the commonest i.e. (31 %) followed by fibrocystic change (22 %), benign epithelial hyperplasia (8.7 %), acute mastitis (3 %), chronic mastitis (2 %), epidermal cyst (1.8 %), subareolar abscess, granulomatous mastitis, galactocele (1 %) and gynaecomastia (8.5 %). In the malignant group, infiltrating ductal carcinoma - not otherwise specified, was the commonest lesion (82.4 %), followed by mucinous carcinoma (8.8 %), papillary carcinoma, medullary carcinoma and metaplastic carcinoma (2.9 %). In this study, the specificity, sensitivity, positive and negative predictive value, and diagnostic accuracy of fine-needle aspiration cytology were 100 %, 90 %, 100 %, 95 %, and 96 %, respectively. CONCLUSIONS FNAC of the breast lump is an easily performed outpatient diagnostic method for determining the nature of the breast mass. KEYWORDS FNAC, Fibroadenoma, Haematoxylin and Eosin, Infiltrating Ductal Carcinoma - Not Otherwise Specified (IDC NOS), May Grunwald Giemsa

scholarly journals Fine needle aspiration cytology (FNAC) in pre-operative diagnosis of breast lesions in Kadapa region of Andhra Pradesh, India

2017 ◽  
Vol 4 (12) ◽  
pp. 4062
Author(s):  
Chakarala Obula Reddy ◽  
Garisa Chandra Mohana Reddy
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Breast Lump ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Palpable Breast ◽  
Needle Aspiration Cytology

Background: Various diagnostic methods have been developed to evaluate the palpable and non-palpable breast lesions, but Fine needle aspiration cytology of the palpable breast masses have become increasingly popular as a diagnostic technique to assess the breast lesions. To study the role of FNAC in diagnosis of breast lumps.Methods: 60 female patients (11-74 years age group) with palpable breast lump were utilized to study the role of Fine needle aspiration cytology for clinically palpable breast lump was carried out in Fathima Institute of Medical Sciences, Kadapa, Andhra Pradesh.Results: Fine needle aspiration cytology revealed benign in 22 patients, suspicious in 3 and 35 malignant lesions were 93.10% with false negative rate of 6.9% and false positive rate of 0%. The overall sensitivity of fine needle aspiration cytology in diagnosing the palpable breast lump in our study was 93.10%, specificity was 100%, positive predictive of 100% and negative predictive value of 90.47%.Conclusions: FNAC is easy to perform and painless procedure and standard tool for diagnosis of breast lumps with high percentage of true positives without virtual complications.

scholarly journals Dual Primary Malignancy: A Rare Organ Combination

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Preetam Acharya ◽  
Anand Ramakrishna ◽  
Tanuj Kanchan ◽  
Rahul Magazine
Keyword(s):  
Ductal Carcinoma ◽  
Needle Aspiration ◽  
Small Cell ◽  
Aspiration Cytology ◽  
Primary Malignancy ◽  
Fine Needle ◽  
Infiltrating Ductal Carcinoma ◽  
Female Smoker ◽  
Needle Aspiration Cytology ◽  
The Right

A 63-year-old female smoker was evaluated for lump over the right breast, fine needle aspiration cytology of which showed infiltrating ductal carcinoma. Investigations also revealed the presence of left upper lobe mass lesion, the biopsy of which suggested small cell carcinoma. The existence of two malignancies having different histopathologies at anatomically distinct sites suggests the diagnosis of dual primary malignancy involving the breast and the lung which, being a rare combination, prompted us to report the case.

scholarly journals Correlation of Fine Needle Aspiration Cytology and Histopathology Diagnosis in the Evaluation of Breast Lumps

2014 ◽  
Vol 2 (2) ◽  
pp. 40-43 ◽  
Author(s):  
Adnan Khan ◽  
Raza Jamali ◽  
Muneeb Jan ◽  
Maria Tasneem
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Ductal Carcinoma ◽  
Needle Aspiration ◽  
Breast Lump ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Breast Lumps

Background: A large number of patients have been suffer from breast cancer worldwide and this trend is increasing. It is difficult to determine whether a lump is benign or malignant from clinical assessment; thus, the need for micropic and tissue analysis arises. Methods: This comparative retrospective cross sectional study was conducted in the Department of Pathology, Rehman Medical Institute, Peshawar, Pakistan from January 2006 to March 2013, to determine the value of fine needle aspiration cytology (FNAC) in the diagnosis of breast lump and to compare the result of FNAC with histological diagnosis to assess its accuracy. Results: Seventy-four  cases with breast lumps were presented for FNAC. Of these, 32.4% were reported as a C2 lesion, 4.1% were reported as benign with atypical cells (C3), 8.1% cases were suspicious for malignancy (C4), and 55.4% were positive for malignancy (C5). On histopathology examination, out of 24 cases which were reported as C2 lesions, 95.8% were benign and 4.1% turned out to be invasive ductal carcinoma. Of the cases that presented as C3 lesions, one was diagnosed as benign duct ectasia, one with ductal carcinoma in situ, and one with invasive ductal carcinoma on histopathological examination. The cases that were diagnosed as C4 lesions all turned out to be carcinoma on histopathology.  In this study, FNAC and histopathology diagnoses were strongly correlated [r 0.92, p <0.001]. Conclusion: Diagnosis of breast lump based on FNAC should be practiced as there is high correlation with histopathological finding. FNAC should be used as a routine diagnostic procedure due to its cost effectiveness, thus maximizing the availability of effective health care to patients with breast lesions.

scholarly journals VALUE OF AgNOR PARAMETERS IN EVALUATION OF EPITHELIAL BREAST LESIONS ON CYTOLOGY

2020 ◽  
pp. 1-4
Author(s):  
Francis Asir Joseph ◽  
Sithy Athiya Munavarah
Keyword(s):  
Assessment Tool ◽  
Malignant Neoplasm ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Aspiration Cytology ◽  
Medical College ◽  
Triple Assessment ◽  
Malignant Breast ◽  
Malignant Lesions ◽  
Needle Aspiration Cytology

Introduction: Fine needle aspiration cytology (FNAC) is traditionally been used as a component of triple assessment tool for evaluation of breast lesions. FNAC being done as a simple outpatient procedure offers a rapid and safe diagnostic approach for breast lesions. The aim of the present study is to assess the value of AgNOR parameters in cytology smears for differentiating benign proliferative and non-proliferative lesions from malignant lesions of breast. And also to correlate the value of AgNOR parameters with Robinson’s cytological scoring system for malignant breast lesions. Materials and Methods: The present prospective study was conducted at the Cytology Laboratory of the Department of Pathology, Tirunelveli Medical College for 1 year duration. 100 cases with breast lump were randomly chosen and aspirated smears were stained with Hematoxylin & Eosin and AgNOR stains. The AgNOR parameters were then evaluated. Results: All the AgNOR parameters showed statistically significant increase in values progressively from non-proliferative benign breast lesions to proliferative breast lesions and then to malignant breast lesions. Conclusion: AgNOR parameters are of great help in differentiating benign from malignant neoplasm and also in differentiating proliferative vs non-proliferative lesions of breast. Mean AgNOR score and SAPA score were found to be more superior in comparison to other AgNOR parameters.

scholarly journals Importance of fine needle aspiration cytology in revealing the spectrum of axillary swelling: An experience with 30 cases

2021 ◽  
Vol 6 (4) ◽  
pp. 263-268
Author(s):  
Tina Rai ◽  
G.S Rai
Keyword(s):  
Early Diagnosis ◽  
Unusual Case ◽  
Ductal Carcinoma ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Granulomatous Lymphadenitis ◽  
Malignant Lesions ◽  
Carcinoma Metastasis ◽  
Needle Aspiration Cytology

FNAC plays an important role in the early diagnosis of the axillary swelling. This study was conducted to document the spectrum of lesions on the patients that came for FNAC with the complain of axillary swelling. Present study was carried out at the Department of Pathology. A total of 30 cases of axillary swelling which were referred for FNAC in the department of Pathology, over the period of 3 months were retrospectively evaluated. All the stained slides of the cases were also reviewed.: From 30 cases there were 13 males and 17 females. On examining the stained slides maximum number of cases presented with chronic granulomatous lymphadenitis followed by Reactive lymphadenitis , Lipoma, Ductal carcinoma metastasis of breast in axillary lymphnode, chronic non-specific lymphadenitis, One unusual case of Hydatid cyst who presenting with axillary swelling was also diagnosed. : FNAC is an important tool in differentiating benign and malignant lesions thus, helps in the proper management of the disease.

scholarly journals Cytomorphological study of palpable breast lumps

2015 ◽  
Vol 5 (10) ◽  
pp. 817-819
Author(s):  
PK Choudhary ◽  
A Koirala ◽  
HS Rimal ◽  
A Deo
Keyword(s):  
Ductal Carcinoma ◽  
Standard Procedure ◽  
Needle Aspiration ◽  
National Health Survey ◽  
Older Age ◽  
Benign Lesions ◽  
Breast Lump ◽  
Female Population ◽  
Malignant Lesions ◽  
Breast Lumps

Background: Breast lump is a very common clinical presentation for which fine needle aspiration cytology is often sought for. Because of it’s significant diagnositic value, FNAC has become a routine tool in the evaluation of the nature of the lesion. The objective of this study was to determine the cytomorphological patterns of breast lump in eastern part of Nepal among individuals attending Nobel Medical College. Materials and Methods: This was a retrospective descriptive study done in department of pathology from December 2012 to June 2015. All individuals presenting with breast lumps was included in this study. FNAC was done as per standard procedure and categorized as per United Kingdom National Health Survey Breast Screening Programme (UK-NHS-BSP) categories and further also categorized in to neoplastic and non-neolastic categories. Results: We studied 771 cases of breast lumps. Occurrence of breast lump was more common in female (97.4%). Neoplastic lesions accounted for 84.1% of cases out of which benign comprised of 94.6% and malignant comprised of 5.6%. Common benign lesions observed were that of fibroadenona (264) and fibrocystic changes (204). Ductal carcinoma was the most common malignant lesions. All malignant lesions were observed in older age and female sex population.Conclusion: Most of the cases of breast lumps are benign in nature and very few accounted for malignant cases. There is predominance of benign lesions in young age and increased malignancy in older age and female population. 

COMPUTED TOMOGRAPHY CORRELATION OF THORACIC LESIONS WITH TRANSTHORACIC FINE NEEDLE ASPIRATION CYTOLOGY AND BIOPSY

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Rajneesh Madhok ◽  
Ashish Gupta ◽  
Lalit Singh ◽  
Tanu Agarwal
Keyword(s):  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Ct Guided ◽  
Fine Needle ◽  
Malignant Lesions ◽  
Needle Aspiration Cytology ◽  
Adequate Tissue

INTRODUCTION: The study is an attempt to evaluate the sensitivity, specificity, positive predictive value, negative predictive value, p Value and complications of CT guided thoracic interventions fine needle aspiration cytology and core biopsy which are used for diagnosing benign and malignant thoracic lesions. MATERIAL AND METHODS: Study included 102 Patients (87 males and 15 females) with age group ranged from 15 to 87 years.A total of 143 CT guided interventions (84 FNAC’s and 59 core biopsies) were performed in 102 patients. The tissue obtained was sent to the laboratory for histopathological and cytological analysis for a final diagnosis which would contribute to patient management. RESULTS: All( 59) core biopsies were successful in procuring adequate tissue for histopathological analysis and the yield of core biopsies was 100% .However out of 84 FNAC’s only 4 were unsuccessful in procuring adequate tissue with a failure rate of 4.8%. Post procedural biopsy complications were only three (2.1%) which were small pneumothorax. There were 75 malignant lesions and 23 benign lesions based on cytology and histopathology (4 were excluded due to inadequate sample). There was good agreement between benign and malignant lesions diagnosed on CT and that diagnosed by pathology. The most common benign and malignant lesions were granulomatous lesion and squamous cell carcinoma. CONCLUSION: Percutaneous CT guided interventions like core biopsy and fine needle aspirations cytology are simple minimal invasive procedures with good patient acceptance and low morbidity and almost negligible mortality. CT guided interventions should be performed early for diagnosis of thoracic lesions.

scholarly journals A Clinicopathologic Study of Various Breast Lesions by Fine Needle Aspiration Cytology (FNAC)

2018 ◽  
Vol 8 (3-4) ◽  
pp. 27-31
Author(s):  
Kazi Farzana Khanam ◽  
Nasima Akter ◽  
Tarana Tabashum ◽  
Abu Khalid Muhammad Maruf Raza ◽  
Asma Ul Hosna ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Clinicopathologic Study ◽  
Needle Aspiration Cytology

scholarly journals Preoperative Multiparametric Ultrasound and Fine Needle Aspiration Cytology evaluation of parotid gland tumors: which is the best technique?

2021 ◽  
Author(s):  
Olga Guiban ◽  
Antonello Rubini ◽  
Daniele Fresilli ◽  
Giuseppe Tiziano Lucarelli ◽  
Massimo Ralli ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Benign Lesions ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Multiparametric Ultrasound

Aims: To evaluate the pre-surgical diagnostic value of Multiparametric Ultrasound (MPUS) and Fine Needle Aspiration Cytology (FNAC) in differentiating parotid gland tumors, comparing the results with histology. Materials and methods:The study enrolled 84 patients with parotid gland lesions surgically treated in a single tertiary center and evaluated by MPUS. Each patient underwent FNAC. Histological examination was considered the gold standard. Results: Histology identified 62 benign tumors and 22 malignancies. In the differential diagnosis between malignant and benign lesions, B-mode Ultrasound (US), Color-Doppler US, Contrast-Enhanced US (CEUS), Elastography (USE) and FNAC showed the following values of sensitivity: 82%, 81%, 86%, 77%, 73% respectively; specificity: 97%, 61%, 95%, 71%, 97% respectively; PPV: 90%, 43%, 86%, 50%, 89% respectively; NPV: 93%, 90%, 95%, 88%, 91% respectively; and accuracy: 89%, 71%, 90%, 78%, 84% re-spectively. Conclusions: CEUS proved to be a valid and accurate method for identifying malignant tumors of parotid gland; the combination of B-mode US with CEUS showed similar diagnostic accuracy, but better sensitivity than CEUS taken alone. USE did not improve the diagnostic performance of the B-mode US, alone or in association with CEUS; however, it revealed the highest diagnostic accuracy in the differentiation between benign lesions. FNAC demonstrated lower values in comparison with CEUS and with USE. Therefore, according to our study, MPUS could be proposed as a valid alternative to FNAC.

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