scholarly journals A Monte Carlo Study on Dose Enhancement in the Presence of Nanoparticles by Photon Source: A Comparison between Various Concentration and Material of Nanoparticles

2021 ◽  
Author(s):  
Arezoo Kazemzadeh ◽  
Habiballah Moradi
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Study ◽  
High Energy ◽  
Energy Sources ◽  
Photon Beams ◽  
Treatment Efficiency ◽  
Dose Enhancement ◽  
Gold Silver ◽  
Photon Source ◽  
Energetic Photon

Purpose: Recently, the application of high atomic number nanoparticles is suggested in the field of radiotherapy to improve physical dose enhancement and hence treatment efficiency. Several factors such as concentration and material of nanoparticles and energy of beam define the amount of dose enhancement in the target in the presence of nanoparticles. Materials and Methods: In this approach, a spherical cell was simulated through the Geant4 Monte Carlo toolkit which contained a nucleus and nanoparticles distributed through the cell. To investigate the effect of the concentration of nanoparticles on the deposited dose, it ranged from 3 mg/g to 30 mg/g for different materials like gold, silver, gadolinium, and platinum. Also, various mono-energetic photon beams included low and high energy sources were applied. Results: The results proved that as the concentration increased, the Dose Enhancement Factor (DEF) enlarged. Overall, almost for all energy and material that were used in this study, the maximum of DEF values occurred in the concentration of 30 mg/g. Moreover, lower energy sources presented higher DEF compared to other sources. The results indicated that the highest amount of DEF transpired for 35 keV photon beams equal to 14.67. Also, the K-edge energy of each material affects DEF values. Conclusion: To obtain a better outcome in the use of nanoparticles in combination with radiotherapy, a higher concentration of nanoparticles and low-energy photons should be considered to optimize the DEF and thus the treatment ratio.

scholarly journals Depth Dose Enhancement on Flattening-Filter-Free Photon Beam: A Monte Carlo Study in Nanoparticle-Enhanced Radiotherapy

2020 ◽  
Vol 10 (20) ◽  
pp. 7052
Author(s):  
James C. L. Chow
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Study ◽  
Photon Beam ◽  
Depth Range ◽  
Photon Beams ◽  
Dose Enhancement ◽  
Au Nps ◽  
Depth Dose ◽  
Flattening Filter Free ◽  
Flattening Filter

The aim of this study is to investigate the variations of depth dose enhancement (DDE) on different nanoparticle (NP) variables, when using the flattening-filter-free (FFF) photon beam in nanoparticle-enhanced radiotherapy. Monte Carlo simulation under a macroscopic approach was used to determine the DDE ratio (DDER) with variables of NP material (gold (Au) and iron (III) oxide (Fe2O3)), NP concentration (3–40 mg/mL) and photon beam (10 MV flattening-filter (FF) and 10 MV FFF). It is found that Au NPs had a higher DDER than Fe2O3 NPs, when the depths were shallower than 6 and 8 cm for the 10 MV FF and 10 MV FFF photon beams, respectively. However, in a deeper depth range of 10–20 cm, DDER for the Au NPs was lower than Fe2O3 NPs mainly due to the beam attenuation and photon energy distribution. It is concluded that DDER for the Au NPs and Fe2O3 NPs decreased with an increase of depth in the range of 10–20 cm, with rate of decrease depending on the NP material, NP concentration and the use of FF in the photon beam.

Monte Carlo study on mucosal dose in oral and naval cavity using photon beams with small field

2011 ◽  
Vol 10 (4) ◽  
pp. 261-271 ◽  
Author(s):  
James C.L. Chow ◽  
Amir M. Owrangi
Keyword(s):  
Monte Carlo ◽  
Beam Energy ◽  
Field Size ◽  
Small Field ◽  
Beam Angle ◽  
Photon Beams ◽  
Dose Ratio ◽  
Dose Enhancement ◽  
Bone Interface ◽  
Energy Beam

AbstractWe study how mucosal dose in the oral or nasal cavity depends on the irradiated small segmental photon fields varying with beam energy, beam angle and mucosa thickness. Dose ratio (mucosal dose with bone underneath to dose at the same point without bone) reflecting the dose enhancement due to the bone backscatter was determined by Monte Carlo simulation (EGSnrc-based code), validated by measurements. Phase space files based on the 6 and 18 MV photon beams with small field size of 1 × 1 cm2, produced by a Varian 21 EX linear accelerator, were generated using the BEAMnrc Monte Carlo code. Mucosa phantoms (mucosa thickness = 1, 2 and 3 mm) with and without a bone under the mucosa were irradiated by photon beams with gantry angles varying from 0 to 30°. Doses along the central beam axis in the mucosa and the dose ratio were calculated with different mucosa thicknesses. For the 6 MV photon beams, the dose at the mucosa-bone interface increased by 44.9–41.7%, when the mucosa thickness increased from 1 to 3 mm for the beam angle ranging from 0 to 30°. These values were lower than those (58.8–53.6%) for the 18 MV photon beams with the same beam angle range. For both the 6 and 18 MV photon beams, depth doses in the mucosa were found to increase with an increase of the beam angle. Moreover, the dose gradient in the mucosa was greater for the 18 MV photon beams compared to the 6 MV. For the dose ratio, it was found that the dose enhancement due to the bone backscatter increased with a decrease of mucosa thickness, and was more significant at both the air-mucosa and mucosa-bone interface. Mucosal dose with bone was investigated by Monte Carlo simulations with different experimental configurations, and was found vary with the beam energy, beam angle and mucosa thickness for a small segmental photon field. The dosimetric information in this study should be considered when searching for an optimized treatment strategy to minimize the mucosal complications in the head-and-neck intensity-modulated radiation therapy.

Advanced kernel methods vs. Monte Carlo-based dose calculation for high energy photon beams

2009 ◽  
Vol 93 (3) ◽  
pp. 645-653 ◽  
Author(s):  
Irina Fotina ◽  
Peter Winkler ◽  
Thomas Künzler ◽  
Jochen Reiterer ◽  
Isabell Simmat ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Kernel Methods ◽  
Dose Calculation ◽  
High Energy ◽  
High Energy Photon ◽  
Photon Beams ◽  
Energy Photon

Poster - Thur Eve - 16: Dependences of Mucosal Dose on Small Photon Beams: A Monte Carlo Study

2010 ◽  
Vol 37 (7Part2) ◽  
pp. 3889-3889
Author(s):  
J Chow ◽  
A Owrangi ◽  
G Grigorov
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Study ◽  
Photon Beams
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