scholarly journals Effects of Preemptive Single Dose Sustained Release Non-Steroidal Anti-Inflammatory Drugs on Postoperative Complications Following Third Molar Surgery

2020 ◽  
Author(s):  
Ahmet Taylan ÇEBİ ◽  
Metin Berk KASAPOĞLU
Keyword(s):  
Single Dose ◽  
Postoperative Complications ◽  
Sustained Release ◽  
Third Molar ◽  
Third Molar Surgery ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Pharmacological Control of Complications Following to Third Molar Removal: Evidence Based on A Meta-Analysis

Drug Research ◽  
2018 ◽  
Vol 69 (01) ◽  
pp. 5-11 ◽  
Author(s):  
Mario Isiordia-Espinoza ◽  
Ronell Bologna-Molina ◽  
Ycenna Hernández-Miramontes ◽  
Juan Zapata-Morales ◽  
Angel Alonso-Castro ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Third Molar ◽  
Qualitative Evaluation ◽  
Clinical Effectiveness ◽  
Cochrane Library ◽  
Third Molar Surgery ◽  
P Value ◽  
Facial Swelling ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Aims The purpose of this meta-analysis was to evaluate the clinical efficacy of non-steroidal anti-inflammatory drugs and dexamethasone on the trismus, postsurgical pain, facial swelling, as well as the analgesic consumption after third molar surgery. Material and Methods The reports were identified in the most important medical databases. Those studies that met the requirements were fully assessed according to the inclusion and exclusion criteria. The quality of each report was evaluated with the Oxford Quality Scale and using the Cochrane Collaboration’s risk of bias tool. Each meta-analysis was done using the technique of mean difference and 95% confidence intervals employing a random effects model with the Review Manager 5.3., from the Cochrane Library. Significant statistical difference was accepted when the p value was less than 0.05 on the test of overall effect (Z value). Results Qualitative evaluation was done using the data of 330 patients extracted from seven articles and the quantitative assessment with data of 200 patients from three reports. It was not observed difference among non-steroidal anti-inflammatory drugs and dexamethasone in any of the clinical effectiveness indicators. Conclusion The outcomes of our meta-analysis indicate that non-steroidal anti-inflammatory drugs and dexamethasone have good therapeutic effect for the management of inflammatory complications following to third molar surgery.

scholarly journals A Meta-Analysis of the Analgesic Efficacy of Single-Doses of Ibuprofen Compared to Traditional Non-Opioid Analgesics Following Third Molar Surgery

2021 ◽  
Vol 14 (4) ◽  
pp. 360
Author(s):  
Lorenzo Franco-de la Torre ◽  
Norma Patricia Figueroa-Fernández ◽  
Diana Laura Franco-González ◽  
Ángel Josabad Alonso-Castro ◽  
Federico Rivera-Luna ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Safety Profile ◽  
Meta Analysis ◽  
Third Molar ◽  
Analgesic Efficacy ◽  
Opioid Analgesics ◽  
Third Molar Surgery ◽  
Number Of Patients ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The purpose of this systematic review was to determine the analgesic efficacy and adverse effects of ibuprofen in comparison with other traditional non-opioid analgesics after third molar surgery. A total of 17 full texts were identified in PubMed and assessed using the Cochrane Collaboration’s risk of bias tool by two independent researchers. The sum of pain intensity differences, total pain relief, the overall evaluation, the number of patients requiring rescue analgesics, and adverse effects were collected. Data were analyzed using the Review Manager Software 5.3. for Windows. A total of 15 articles met the criteria. The qualitative and quantitative analysis showed that ibuprofen is more effective to relieve post-operative dental pain than acetaminophen, meclofenamate, aceclofenac, bromfenac, and aspirin. Moreover, ibuprofen and traditional non-steroidal anti-inflammatory drugs have a similar safety profile. In conclusion, ibuprofen 400 mg appears to have good analgesic efficacy and a safety profile similar to other traditional non-steroidal anti-inflammatory drugs after third molar surgery.

In Vitro Chondrotoxicity of Nonsteroidal Anti-inflammatory Drugs and Opioid Medications

2017 ◽  
Vol 45 (14) ◽  
pp. 3345-3350 ◽  
Author(s):  
Geoffrey D. Abrams ◽  
Wenteh Chang ◽  
Jason L. Dragoo
Keyword(s):  
Cell Death ◽  
Single Dose ◽  
Joint Surface ◽  
Saline Control ◽  
Type I ◽  
Dose Equivalent ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Opioid Medications

Background: A variety of medications are administered to the intra-articular space for the relief of joint pain. While amide-type local anesthetics have been extensively studied, there is minimal information regarding the potential chondrotoxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) and opioid medications. Purpose: To investigate the in vitro chondrotoxicity of single-dose equivalent concentrations of ketorolac, morphine, meperidine, and fentanyl on human chondrocytes. Study Design: Controlled laboratory study. Methods: Human cartilage was arthroscopically harvested from the intercondylar notch and expanded in vitro. Gene expression of cultured chondrocytes before treatment was performed with quantitative polymerase chain reaction for type I collagen, type II collagen, aggrecan, and SOX9. Chondrocytes were then exposed to 0.01%, 0.02%, and 0.04% morphine sulfate; 0.3% and 0.6% ketorolac tromethamine; 0.5%, 1.0%, and 1.5% meperidine hydrochloride; 0.0005% and 0.001% fentanyl citrate; and saline. A custom bioreactor was used to constantly deliver medications, with the dosage of each medication and the duration of exposure based on standard dose equivalents, medication half-lives, and differences in the surface area between the 6-well plates and the native joint surface. After treatment, a live/dead assay was used to assess chondrocyte viability and if minimal cell death was detected. A subset of samples after treatment was maintained to analyze for possible delayed cell death. Results: All tested concentrations of ketorolac and meperidine caused significantly increased cell death versus the saline control, demonstrating a dose-response relationship. The morphine and fentanyl groups did not show increased chondrotoxicity compared with the saline group, even after 2 weeks of additional culture. Conclusion: In vitro exposure of chondrocytes to single-dose equivalent concentrations of either ketorolac or meperidine demonstrated significant chondrotoxicity, while exposure to morphine or fentanyl did not lead to increased cell death.

scholarly journals Reliability and validity of measuring scale for postoperative complications in third molar surgery

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Pedro Christian Aravena ◽  
Paula Astudillo ◽  
Horacio Miranda ◽  
Carlos Manterola
Keyword(s):  
Postoperative Complications ◽  
Third Molar ◽  
Reliability And Validity ◽  
Third Molar Surgery ◽  
Measuring Scale
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