scholarly journals A Meta-Analysis of the Analgesic Efficacy of Single-Doses of Ibuprofen Compared to Traditional Non-Opioid Analgesics Following Third Molar Surgery

2021 ◽  
Vol 14 (4) ◽  
pp. 360
Author(s):  
Lorenzo Franco-de la Torre ◽  
Norma Patricia Figueroa-Fernández ◽  
Diana Laura Franco-González ◽  
Ángel Josabad Alonso-Castro ◽  
Federico Rivera-Luna ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Safety Profile ◽  
Meta Analysis ◽  
Third Molar ◽  
Analgesic Efficacy ◽  
Opioid Analgesics ◽  
Third Molar Surgery ◽  
Number Of Patients ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The purpose of this systematic review was to determine the analgesic efficacy and adverse effects of ibuprofen in comparison with other traditional non-opioid analgesics after third molar surgery. A total of 17 full texts were identified in PubMed and assessed using the Cochrane Collaboration’s risk of bias tool by two independent researchers. The sum of pain intensity differences, total pain relief, the overall evaluation, the number of patients requiring rescue analgesics, and adverse effects were collected. Data were analyzed using the Review Manager Software 5.3. for Windows. A total of 15 articles met the criteria. The qualitative and quantitative analysis showed that ibuprofen is more effective to relieve post-operative dental pain than acetaminophen, meclofenamate, aceclofenac, bromfenac, and aspirin. Moreover, ibuprofen and traditional non-steroidal anti-inflammatory drugs have a similar safety profile. In conclusion, ibuprofen 400 mg appears to have good analgesic efficacy and a safety profile similar to other traditional non-steroidal anti-inflammatory drugs after third molar surgery.

Pharmacological Control of Complications Following to Third Molar Removal: Evidence Based on A Meta-Analysis

Drug Research ◽  
2018 ◽  
Vol 69 (01) ◽  
pp. 5-11 ◽  
Author(s):  
Mario Isiordia-Espinoza ◽  
Ronell Bologna-Molina ◽  
Ycenna Hernández-Miramontes ◽  
Juan Zapata-Morales ◽  
Angel Alonso-Castro ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Third Molar ◽  
Qualitative Evaluation ◽  
Clinical Effectiveness ◽  
Cochrane Library ◽  
Third Molar Surgery ◽  
P Value ◽  
Facial Swelling ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Aims The purpose of this meta-analysis was to evaluate the clinical efficacy of non-steroidal anti-inflammatory drugs and dexamethasone on the trismus, postsurgical pain, facial swelling, as well as the analgesic consumption after third molar surgery. Material and Methods The reports were identified in the most important medical databases. Those studies that met the requirements were fully assessed according to the inclusion and exclusion criteria. The quality of each report was evaluated with the Oxford Quality Scale and using the Cochrane Collaboration’s risk of bias tool. Each meta-analysis was done using the technique of mean difference and 95% confidence intervals employing a random effects model with the Review Manager 5.3., from the Cochrane Library. Significant statistical difference was accepted when the p value was less than 0.05 on the test of overall effect (Z value). Results Qualitative evaluation was done using the data of 330 patients extracted from seven articles and the quantitative assessment with data of 200 patients from three reports. It was not observed difference among non-steroidal anti-inflammatory drugs and dexamethasone in any of the clinical effectiveness indicators. Conclusion The outcomes of our meta-analysis indicate that non-steroidal anti-inflammatory drugs and dexamethasone have good therapeutic effect for the management of inflammatory complications following to third molar surgery.

scholarly journals Analgesic Efficacy of Etoricoxib following Third Molar Surgery: A Meta-analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Lorenzo Franco-de la Torre ◽  
Diana Laura Franco-González ◽  
Lorena Michele Brennan-Bourdon ◽  
Nelly Molina-Frechero ◽  
Ángel Josabad Alonso-Castro ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Naproxen Sodium ◽  
Meta Analysis ◽  
Third Molar ◽  
Analgesic Efficacy ◽  
Third Molar Surgery ◽  
Total Consumption ◽  
Number Of Patients ◽  
Review Manager

Background. The purpose of this meta-analysis was to assess the clinical efficacy of etoricoxib in comparison with traditional NSAIDs for postoperative pain after third molar surgery. Methods. The quality of studies found in PubMed and Google Scholar was evaluated with Cochrane Collaboration’s risk of bias tool. Data on total consumption of rescue analgesics, number of patients using rescue analgesics, global assessment of study treatments, and adverse effects were extracted exclusively from high-quality clinical trials. Each meta-analysis was performed with the Review Manager Software 5.3 for Windows. Results. The qualitative analysis showed that etoricoxib has better analgesic activity when compared with ibuprofen (2 clinical trials) and diclofenac (1 clinical trial). A similar analgesic efficacy between etoricoxib and nonselective Cox-2 NSAIDs was informed in 3/8 studies (2 compared to ibuprofen and 1 to naproxen sodium). Moreover, the number of patients requiring rescue analgesics in the postoperative period showed a statistical difference in favor of etoricoxib when compared to NSAIDs. Conclusion. Etoricoxib significantly reduces the number of patients needing rescue analgesics compared to NSAIDs after third molar surgery.

scholarly journals Infection, Alveolar Osteitis, and Adverse Effects Using Metronidazole in Healthy Patients Undergoing Third Molar Surgery: A Meta-analysis

2017 ◽  
Vol 17 (2) ◽  
pp. 142-149
Author(s):  
Mario Alberto Isiordia-Espinoza ◽  
Othoniel H. Aragon-Martinez ◽  
Ronell E. Bollogna-Molina ◽  
Ángel J. Alonso-Castro
Keyword(s):  
Adverse Effects ◽  
Meta Analysis ◽  
Third Molar ◽  
Third Molar Surgery ◽  
Alveolar Osteitis

scholarly journals Does the Preemptive Use of Oral Nonsteroidal Anti-inflammatory Drugs Reduce Postoperative Pain in Surgical Removal of Third Molars? A Meta-analysis of Randomized Clinical Trials

2015 ◽  
Vol 62 (2) ◽  
pp. 57-63 ◽  
Author(s):  
Fábio Wildson Gurgel Costa ◽  
Diego Felipe Silveira Esses ◽  
Paulo Goberlânio de Barros Silva ◽  
Francisco Samuel Rodrigues Carvalho ◽  
Carlos Diego Lopes Sá ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Third Molar ◽  
Preemptive Analgesia ◽  
Surgical Removal ◽  
Third Molars ◽  
Inflammatory Drugs ◽  
Cox 2 ◽  
Anti Inflammatory

Abstract The purpose of this study was to investigate the effectiveness of preemptive analgesia with nonsteroidal anti-inflammatory drugs (NSAIDs) in third-molar surgery. A PubMed literature search was conducted for articles restricted to the English language using the following terms (DeCS/MeSH) or combinations: analgesia, third molar, and preemptive. From a total of 704 articles, 6 (n = 420 subjects) were selected. All studies presented a low risk of bias (Cochrane criteria) but exhibited high heterogeneity of methods. Two studies were excluded from the meta-analysis because they did not have adequate numeric values (dichotomous data) for the calculations. Preemptive analgesia showed no significant benefit (n = 298, P = .2227, odds ratio: 2.30, 0.60–8.73) in reducing postoperative pain after removal of lower impacted third molars. However, there was a probable direct relationship between the effectiveness of NSAIDs in preemptive analgesia for removal of third molars and its selectivity for the cyclooxygenase-2 (COX-2). Preemptive analgesia did not have a significant effect in reducing postoperative pain after removal of lower impacted third molars. More homogeneous and well-delineated clinical studies are necessary to determine a possible association between NSAIDs' selectivity for COX-2 and treatment effectiveness.

scholarly journals Oxycodone versus other opioid analgesics after laparoscopic surgery: a meta-analysis

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Yan Li ◽  
Zhi Dou ◽  
Liqiang Yang ◽  
Qi Wang ◽  
Jiaxiang Ni ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
Laparoscopic Surgery ◽  
Adverse Effects ◽  
Adverse Events ◽  
Systematic Reviews ◽  
Visceral Pain ◽  
Meta Analysis ◽  
Analgesic Efficacy ◽  
Opioid Analgesics ◽  
Significant Difference

Abstract Background Intravenous opioids are administered for the management of visceral pain after laparoscopic surgery. Whether oxycodone has advantages over other opioids in the treatment of visceral pain is not yet clear. Methods In this study, the analgesic efficiency and adverse events of oxycodone and other opioids, including alfentanil, sufentanil, fentanyl, and morphine, in treating post-laparoscopic surgery visceral pain were evaluated. This review was conducted according to the methodological standards described in the Cochrane Handbook for Systematic Reviews of Interventions and the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. The PubMed, Embase, and Cochrane databases were searched in December 2019. Results Ten studies were included in this review. The sample size was 695 participants. The results showed that compared with morphine and fentanyl, oxycodone had a more potent analgesic efficacy on the first day after laparoscopic surgery, especially during the first 0.5 h. There was no significant difference in sedation between the two groups. Compared to morphine and fentanyl, oxycodone was more likely to lead to dizziness and drowsiness. Overall, patient satisfaction did not differ significantly between oxycodone and other opioids. Conclusions Oxycodone is superior to other analgesics within 24 h after laparoscopic surgery, but its adverse effects should be carefully considered.

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