INFLUENCE OF THE DEXTRAN 70 ON AGGREGATION ANTITUMOR CYTOKINE EMAP II

SummaryThe susceptibility to lysis of artificial thrombi formed from native rabbit blood in the presence or absence of dextran was determined using the Chandler loop technique. Thrombi of identical weight were formed in the presence of saline or dextran and when spontaneous thrombolysis was allowed to take place, thrombi formed in the presence of dextran 70 were lysed to a greater extent than those formed under control conditions.The possible factors influencing this observation were studied. Increasing concentrations of streptokinase increased the extent of thrombolysis in both control and dextran treated thrombi. Maximal streptokinase induced thrombolysis occurred in the presence of a 2 per cent final concentration of dextran Mw 40,000 and 500,000 and dextran 70 at a final concentration of 1.2 per cent.Increased thrombolysis was not observed when albumin was substituted for dextran.Finally, similar observations were recorded for streptokinase induced thrombolysis using human blood.

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EMAP II-Based Antiangiogenic-Antiendothelial In Vivo Combination Therapy of Pancreatic Cancer

Annals of Surgical Oncology ◽

10.1245/s10434-009-0879-5 ◽

2009 ◽

Vol 17 (5) ◽

pp. 1442-1452 ◽

Cited By ~ 17

Author(s):

Roderich E. Schwarz ◽

Niranjan Awasthi ◽

Srivani Konduri ◽

Danielle Cafasso ◽

Margaret A. Schwarz

Keyword(s):

Pancreatic Cancer ◽

Combination Therapy ◽

Emap Ii

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Prophylaxis of postoperative venous thrombosis in a controlled trial comparing dextran 70 and low-dose heparin

World Journal of Surgery ◽

10.1007/bf02393589 ◽

1980 ◽

Vol 4 (2) ◽

pp. 239-243 ◽

Cited By ~ 29

Author(s):

David Bergqvist ◽

Torgil Hallböök

Keyword(s):

Venous Thrombosis ◽

Low Dose ◽

Controlled Trial ◽

Dose Heparin ◽

Dextran 70 ◽

Low Dose Heparin

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Effects of ketorolac and dextran-70 alone and in combination on haemostasis

Acta Anaesthesiologica Scandinavica ◽

10.1111/j.1399-6576.1998.tb05359.x ◽

1998 ◽

Vol 42 (8) ◽

pp. 982-986 ◽

Cited By ~ 2

Author(s):

I. Power ◽

D. W. Noble ◽

A. Winter ◽

I. A. Greer

Keyword(s):

Dextran 70

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Noncardiogenic pulmonary edema secondary to intrauterine instillation of 32% dextran 70

Fertility and Sterility ◽

10.1016/s0015-0282(16)48453-0 ◽

1985 ◽

Vol 43 (3) ◽

pp. 479-480 ◽

Cited By ~ 24

Author(s):

Edward A. Zbella ◽

Jacob Moise ◽

Sandra A. Carson

Keyword(s):

Pulmonary Edema ◽

Dextran 70

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Dextran 70 in Dextrose Injection

10.31003/uspnf_m23860_03_01 ◽

2021 ◽

Keyword(s):

Dextran 70

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Dextran and postoperative thromboembolism

Drug and Therapeutics Bulletin ◽

10.1136/dtb.13.11.41 ◽

1975 ◽

Vol 13 (11) ◽

pp. 41-43

Keyword(s):

Platelet Aggregation ◽

Coagulation Factors ◽

Venous Thromboembolic Disease ◽

Vein Thrombosis ◽

Dextran 70 ◽

Lower Blood ◽

Venous Thromboembolic ◽

Reduce Platelet Aggregation ◽

Increase Platelet Aggregation ◽

Deep Vein

Two preparations of dextran have been tried for prevention of venous thromboembolic disease, dextran-40 (average m. w. 40,000) and dextran-70 (average m.w. 70,000). Dextrans reduce platelet aggregation and lower blood viscosity.1 Dextran may also reduce the peri-operative rise in the coagulation factors V and VIII.2 However, in some tests dextrans increase platelet aggregation3 and accelerate fibrin formation,4 so that only clinical trial can show whether dextran reduces the incidence of either deep-vein thrombosis or of pulmonary embolism.

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