scholarly journals Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells

Aging ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 860-879 ◽  
Author(s):  
Asim Ejaz ◽  
Monika Mattesich ◽  
Werner Zwerschke
Keyword(s):  
Progenitor Cells ◽  
Cellular Senescence ◽  
Small Gtpase ◽  
Stromal Progenitor Cells

Changes in bone marrow stromal progenitor cells in patients with hemoblastosis at the onset of the disease

2021 ◽  
pp. 130-135
Author(s):  
N. A. Petinati ◽  
◽  
I. N. Shipunova ◽  
E. A. Fastova ◽  
A. U. Magomedova ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Progenitor Cells ◽  
Stromal Progenitor Cells

scholarly journals Small GTPase RAB45-mediated p38 activation in apoptosis of chronic myeloid leukemia progenitor cells

2011 ◽  
Vol 32 (12) ◽  
pp. 1758-1772 ◽  
Author(s):  
S. Nakamura ◽  
T. Takemura ◽  
L. Tan ◽  
Y. Nagata ◽  
D. Yokota ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Progenitor Cells ◽  
Myeloid Leukemia ◽  
Small Gtpase

Stromal Progenitor Cells Present Within Liposuction and Reduction Abdominoplasty Fat for Autologous Transfer to Aged Skin

1999 ◽  
Vol 25 (12) ◽  
pp. 945-949 ◽  
Author(s):  
Mitchell Stashower ◽  
Kathleen Smith ◽  
John Williams ◽  
Henry Skelton
Keyword(s):  
Progenitor Cells ◽  
Aged Skin ◽  
Stromal Progenitor Cells

scholarly journals Unique characteristics of human mesenchymal stromal/progenitor cells pre-activated in 3-dimensional cultures under different conditions

Cytotherapy ◽  
2014 ◽  
Vol 16 (11) ◽  
pp. 1486-1500 ◽  
Author(s):  
Joni H. Ylostalo ◽  
Thomas J. Bartosh ◽  
April Tiblow ◽  
Darwin J. Prockop
Keyword(s):  
Progenitor Cells ◽  
3 Dimensional ◽  
Stromal Progenitor Cells

The Effect of Low Dose Rate on Recovery of Hemopoietic and Stromal Progenitor Cells in γ-Irradiated Mouse Bone Marrow

1988 ◽  
Vol 115 (3) ◽  
pp. 481 ◽  
Author(s):  
R. Gallini ◽  
J. H. Hendry ◽  
G. Molineux ◽  
N. G. Testa
Keyword(s):  
Bone Marrow ◽  
Dose Rate ◽  
Progenitor Cells ◽  
Low Dose ◽  
Mouse Bone Marrow ◽  
Low Dose Rate ◽  
Stromal Progenitor Cells

RECOVERY OF HEMOPOIETIC STROMAL PROGENITOR CELLS AFTER LETHAL TOTAL-BODY IRRADIATION AND BONE MARROW TRANSPLANTATION IN MICE

1985 ◽  
Vol 40 (2) ◽  
pp. 198-200 ◽  
Author(s):  
ALDERT H. PIERSMA ◽  
KELVIN G. M. BROCKBANK ◽  
ROB E. PLOEMACHER ◽  
CECILE P. E. OTTENHEIM
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Progenitor Cells ◽  
Total Body Irradiation ◽  
Marrow Transplantation ◽  
Stromal Progenitor Cells ◽  
Total Body

scholarly journals Isolation and characterization of stromal progenitor cells from ascites of patients with epithelial ovarian adenocarcinoma

2012 ◽  
Vol 19 (1) ◽  
pp. 23 ◽  
Author(s):  
Chih-Ming Ho ◽  
Shwu-Fen Chang ◽  
Chih-Chiang Hsiao ◽  
Tsai-Yen Chien ◽  
Daniel Shih
Keyword(s):  
Progenitor Cells ◽  
Ovarian Adenocarcinoma ◽  
Isolation And Characterization ◽  
Stromal Progenitor Cells

scholarly journals Human Cytomegalovirus miR-US25-1 Targets the GTPase RhoA To Inhibit CD34+ Hematopoietic Progenitor Cell Proliferation To Maintain the Latent Viral Genome

mBio ◽  
2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Nicole L. Diggins ◽  
Lindsey B. Crawford ◽  
Meaghan H. Hancock ◽  
Jennifer Mitchell ◽  
Jay A. Nelson
Keyword(s):  
Cell Division ◽  
Progenitor Cells ◽  
Human Cytomegalovirus ◽  
Viral Genome ◽  
Small Gtpase ◽  
Hematopoietic Progenitor Cells ◽  
Hematopoietic Progenitor Cell ◽  
Hematopoietic Progenitor ◽  
Host Chromosome ◽  
Inhibition Of Proliferation

ABSTRACT Human cytomegalovirus (HCMV) microRNAs play essential roles in latency and reactivation in CD34+ hematopoietic progenitor cells (HPCs) via regulation of viral and cellular gene expression. In the present study, we show that HCMV miR-US25-1 targets RhoA, a small GTPase required for CD34+ HPC self-renewal, proliferation, and hematopoiesis. Expression of miR-US25-1 impairs signaling through the nonmuscle myosin II light chain, which leads to a block in cytokinesis and an inhibition of proliferation. Moreover, infection with an HCMV mutant lacking miR-US25-1 resulted in increased proliferation of CD34+ HPCs and a decrease in the proportion of genome-containing cells at the end of latency culture. These observations provide a mechanism by which HCMV limits proliferation to maintain latent viral genomes in CD34+ HPCs. IMPORTANCE Each herpesvirus family establishes latency in a unique cell type. Since herpesvirus genomes are maintained as episomes, the virus needs to devise mechanisms to retain the latent genome during cell division. Alphaherpesviruses overcome this obstacle by infecting nondividing neurons, while gammaherpesviruses tether their genome to the host chromosome in dividing B cells. The betaherpesvirus human cytomegalovirus (HCMV) establishes latency in CD34+ hematopoietic progenitor cells (HPCs), but the mechanism used to maintain the viral genome is unknown. In this report, we demonstrate that HCMV miR-US25-1 downregulates expression of RhoA, a key cell cycle regulator, which results in inhibition of CD34+ HPC proliferation by blocking mitosis. Mutation of miR-US25-1 during viral infection results in enhanced cellular proliferation and a decreased frequency of genome-containing CD34+ HPCs. These results reveal a novel mechanism through which HCMV is able to regulate cell division to prevent viral genome loss during proliferation.

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