A dual inhibitor targeting HMG-CoA reductase and histone deacetylase mitigates neurite degeneration in LRRK2-G2019S parkinsonism

Aging ◽

10.18632/aging.104165 ◽

2020 ◽

Author(s):

Chin-Hsien Lin ◽

Han-Yi Lin ◽

Jim-Min Fang ◽

Ching-Chow Chen

Keyword(s):

Histone Deacetylase ◽

Dual Inhibitor ◽

Hmg Coa Reductase ◽

Lrrk2 G2019s ◽

Coa Reductase ◽

Neurite Degeneration

Development of a dual inhibitor targeting HMG-CoA reductase and histone deacetylase rescues neurite degeneration in LRRK2- G2019S parkinsonism

Journal of the Neurological Sciences ◽

10.1016/j.jns.2017.08.246 ◽

2017 ◽

Vol 381 ◽

pp. 67-68 ◽

Cited By ~ 1

Author(s):

C.H. Lin ◽

H.I. Lin ◽

J.M. Fang ◽

L.P. Cao ◽

M.J. Farrer ◽

...

Keyword(s):

Histone Deacetylase ◽

Dual Inhibitor ◽

Hmg Coa Reductase ◽

Lrrk2 G2019s ◽

Coa Reductase ◽

Neurite Degeneration

Structural Modification of Natural Product Ganomycin I Leading to Discovery of a α-Glucosidase and HMG-CoA Reductase Dual Inhibitor Improving Obesity and Metabolic Dysfunction in Vivo

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.8b00107 ◽

2018 ◽

Vol 61 (8) ◽

pp. 3609-3625 ◽

Cited By ~ 23

Author(s):

Kai Wang ◽

Li Bao ◽

Nan Zhou ◽

Jinjin Zhang ◽

Mingfang Liao ◽

...

Keyword(s):

Natural Product ◽

Structural Modification ◽

Metabolic Dysfunction ◽

Dual Inhibitor ◽

Hmg Coa Reductase ◽

Coa Reductase

Reduction of HMG-CoA-reductase leads to improved cardiac function in doxorubicin-induced cardiomyopathy in mice

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(08)60560-3 ◽

2008 ◽

Vol 7 ◽

pp. 202-203

Author(s):

A RIAD ◽

S BIEN ◽

F ESCHER ◽

D WESTERMANN ◽

U LANDMESSER ◽

...

Keyword(s):

Cardiac Function ◽

Hmg Coa Reductase ◽

Coa Reductase

1308 Increased Rac-1 activity in heart failure is associated with increased oxidative stress and is reduced by HMG-COA reductase inhibition

European Heart Journal ◽

10.1016/s0195-668x(03)94566-0 ◽

2003 ◽

Vol 24 (5) ◽

pp. 248

Author(s):

C MAACK

Keyword(s):

Oxidative Stress ◽

Heart Failure ◽

Hmg Coa Reductase ◽

Coa Reductase

Use of HMG-CoA Reductase Inhibitors Is Associated With Lower Plasma Interleukin-6 Levels and a Favourable Cardiac Course in Unstable Angina

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)85097-8 ◽

1998 ◽

Vol 31 (2) ◽

pp. 318A

Author(s):

P Verheggen

Keyword(s):

Unstable Angina ◽

Interleukin 6 ◽

Lower Plasma ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase

Similarity of molecular electrostatic potential distributions in a series of HMG-CoA reductase inhibitors. Preliminary results

Journal de Chimie Physique ◽

10.1051/jcp/1991882639 ◽

1991 ◽

Vol 88 ◽

pp. 2639-2644 ◽

Cited By ~ 1

Author(s):

U Cosentino ◽

G Moro ◽

D Pitea

Keyword(s):

Electrostatic Potential ◽

Molecular Electrostatic Potential ◽

Hmg Coa Reductase ◽

Preliminary Results ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase

Computational evaluation of Isoorientin (C-glycosyl flavone) on PPAR-gamma receptors and HMG- CoA reductase using MOE 2008.10

Planta Medica ◽

10.1055/s-0029-1234744 ◽

2009 ◽

Vol 75 (09) ◽

Author(s):

O Fidan ◽

M Aslan ◽

M Mor

Keyword(s):

Ppar Gamma ◽

Hmg Coa Reductase ◽

Computational Evaluation ◽

Coa Reductase

Antioxidative and Inhibitory Effects of the Fruiting Body of Black Lingzhi Mushroom, Amauroderma rugosum (Agaricomycetes), on LDL Oxidation and HMG-CoA Reductase Activity

International Journal of Medicinal Mushrooms ◽

10.1615/intjmedmushrooms.2017024374 ◽

2017 ◽

Vol 19 (9) ◽

pp. 797-807 ◽

Cited By ~ 1

Author(s):

Chan Kam Seng ◽

Noorlidah Abdullah ◽

Norhaniza Aminudin

Keyword(s):

Fruiting Body ◽

Reductase Activity ◽

Ldl Oxidation ◽

Inhibitory Effects ◽

Hmg Coa Reductase ◽

Coa Reductase

Preventing Levodopa Induced Dyskinesia in Parkinson's Disease With HMG-CoA Reductase Inhibitors

Case Medical Research ◽

10.31525/ct1-nct04064294 ◽

2019 ◽

Author(s):

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase

Faculty Opinions recommendation of Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1028177.335051 ◽

2005 ◽

Author(s):

Douglas Cyr

Keyword(s):

Ubiquitin Ligase ◽

Hmg Coa Reductase ◽

Coa Reductase