scholarly journals Transplantation of olfactory ensheathing cells promotes the therapeutic effect of neural stem cells on spinal cord injury by inhibiting necrioptosis

Aging ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 9056-9070
Author(s):  
Xiaoyu Wang ◽  
Naifeng Kuang ◽  
Yuexia Chen ◽  
Guifeng Liu ◽  
Nan Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Therapeutic Effect ◽  
Olfactory Ensheathing Cells ◽  
Cord Injury ◽  
Ensheathing Cells

scholarly journals Synergistic Effect of Neural Stem Cells and Olfactory Ensheathing Cells on Repair of Adult Rat Spinal Cord Injury

2010 ◽  
Vol 19 (10) ◽  
pp. 1325-1337 ◽  
Author(s):  
Gan Wang ◽  
Qiang Ao ◽  
Kai Gong ◽  
Huancong Zuo ◽  
Yandao Gong ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Synergistic Effect ◽  
Neural Stem Cells ◽  
Olfactory Ensheathing Cells ◽  
Rat Spinal Cord ◽  
Adult Rat ◽  
Cord Injury ◽  
Adult Rat Spinal Cord

scholarly journals Transplantation of Wnt4-modified Neural Stem Cells Mediate M2 Polarization to Promote Spinal Cord Injury Repair

2021 ◽  
Author(s):  
Xiang Li ◽  
Lingli Long ◽  
Yue Hu ◽  
Wenwu Zhang ◽  
Fangling Zhong ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Therapeutic Effect ◽  
Signal Pathway ◽  
Inflammatory Microenvironment ◽  
M2 Polarization ◽  
M1 Polarization ◽  
Cord Injury

Abstract Background: Neural stem cells (NSCs) transplantation has been considered as a potential strategy to reconnect the neural circuit after spinal cord injury (SCI) but the therapeutic effect was still unsatisfied because of the poor inflammatory microenvironment. Wnt4 has been considered to be neurogenesis and anti-inflammatory so that it would be an essential assistant agent for NSCs transplantation. To explore interaction between Wnt4-modified NSCs and macrophages; and the effect of Wnt4-modified NSCs on the inflammatory microenvironment of SCI is relevant for targeted and effective treatments that promote injured spinal cord repair. Methods: In vitro NSCs-macrophages co-cultured system was established to unravel the interaction and involved mechanism between Wnt4-modified NSCs and macrophages. Wnt4-modified NSCs were transplanted into SCI model to confirm the effect of Wnt4-modified NSCs on modulation of inflammatory microenvironment of SCI and the therapeutic effect of Wnt4-modified NSCs on SCI. Results: Wnt4-modified NSCs induce M2 polarization and inhibit M1 polarization of macrophages through suppress TLR4/NF-κB signal pathway; furthermore, M2 cells promote neuronal differentiation of NSCs through MAPK/JNK signal pathway. In vivo, transplantation of Wnt4-modified NSCs improve inflammatory microenvironment through induce M2 polarization and inhibit M1 polarization of macrophages to promote axonal regeneration and tissue repair.Conclusions: Transplantation of Wnt4-modified NSCs effectively improve the inflammatory microenvironment through inducing M2 polarization and suppressing M1 polarization of macrophages after SCI. Considering these positive therapeutic effects, Wnt4 may have remarkable potential to be optimal assistant agent in NSCs transplantation for SCI.

Properties of Olfactory Ensheathing Cells Conditioned Medium and Its Potential Therapeutic Effect on Spinal Cord Injury: A Review

2018 ◽  
Vol 5 ◽  
pp. 1-13 ◽  
Author(s):  
Zhengchao Gao ◽  
Yingjie Zhao ◽  
Yiqun Wang ◽  
Jiantao Liu ◽  
Binbin Niu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Conditioned Medium ◽  
Therapeutic Effect ◽  
Olfactory Ensheathing Cells ◽  
Cord Injury ◽  
Ensheathing Cells

scholarly journals Therapeutic Potential of Olfactory Ensheathing Cells and Mesenchymal Stem Cells in Spinal Cord Injuries

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Zadroga Anna ◽  
Jezierska-Woźniak Katarzyna ◽  
Czarzasta Joanna ◽  
Monika Barczewska ◽  
Wojtkiewicz Joanna ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Spinal Cord Injuries ◽  
Therapeutic Potential ◽  
Current Knowledge ◽  
Olfactory Ensheathing Cells ◽  
Cord Injury ◽  
Ensheathing Cells

Spinal cord injury (SCI) is a devastating neurological condition that affects individuals worldwide, significantly reducing quality of life, for both patients and their families. In recent years there has been a growing interest in cell therapy potential in the context of spinal cord injuries. The present review aims to discuss and compare the restorative approaches based on the current knowledge, available spinal cord restorative cell therapies, and use of selected cell types. However, treatment options for spinal cord injury are limited, but rehabilitation and experimental technologies have been found to help maintain or improve remaining nerve function in some cases. Mesenchymal stem cells as well as olfactory ensheathing cells seem to show therapeutic impact on damaged spinal cord and might be useful in neuroregeneration. Recent research in animal models and first human trials give patients with spinal cord injuries hope for recovery.

Effect of stiffness change of transplanted induced neural stem cells after spinal cord injury using silk hydrogel

2017 ◽  
Vol 381 ◽  
pp. 286
Author(s):  
G. Davaa ◽  
J.Y. Hong ◽  
J. Olmos Buitrago ◽  
H.W. Kim ◽  
J.K. Hyun
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Cord Injury ◽  
Induced Neural Stem Cells ◽  
Silk Hydrogel

scholarly journals Immunosuppressants Affect Human Neural Stem Cells In Vitro but Not in an In Vivo Model of Spinal Cord Injury

2013 ◽  
Vol 2 (10) ◽  
pp. 731-744 ◽  
Author(s):  
Christopher J. Sontag ◽  
Hal X. Nguyen ◽  
Noriko Kamei ◽  
Nobuko Uchida ◽  
Aileen J. Anderson ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
In Vivo Model ◽  
Human Neural Stem Cells ◽  
Cord Injury

scholarly journals Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury

2021 ◽  
pp. 113660
Author(s):  
Jon Prager ◽  
Daisuke Ito ◽  
Darren R. Carwardine ◽  
Prince Jiju ◽  
Divya M. Chari ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Olfactory Ensheathing Cells ◽  
Cord Injury ◽  
Ensheathing Cells
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