scholarly journals Aging-dependent loss of GAP junction proteins Cx46 and Cx50 in the fiber cells of human and mouse lenses accounts for the diminished coupling conductance

Aging ◽  
2021 ◽  
Author(s):  
Xiao-Dong Gong ◽  
Yan Wang ◽  
Xue-Bin Hu ◽  
Shu-Yu Zheng ◽  
Jia-Ling Fu ◽  
...  
Keyword(s):  
Gap Junction ◽  
Fiber Cells ◽  
Gap Junction Proteins ◽  
Coupling Conductance ◽  
Human And Mouse ◽  
Junction Proteins

Innexin genes and gap junction proteins in the locust frontal ganglion

2009 ◽  
Vol 39 (3) ◽  
pp. 224-233 ◽  
Author(s):  
Sarit Anava ◽  
David Rand ◽  
Yael Zilberstein ◽  
Amir Ayali
Keyword(s):  
Gap Junction ◽  
Frontal Ganglion ◽  
Gap Junction Proteins ◽  
Junction Proteins

Gap-junction proteins and communication in human epidermis

Gap Junctions ◽  
1993 ◽  
pp. 225-231 ◽  
Author(s):  
D. SALOMON ◽  
E. MASGRAU ◽  
S. VISCHER ◽  
J.-H. SAURAT ◽  
M. CHANSON ◽  
...  
Keyword(s):  
Gap Junction ◽  
Human Epidermis ◽  
Gap Junction Proteins ◽  
Junction Proteins

scholarly journals Connexin Mutants Compromise the Lens Circulation and Cause Cataracts through Biomineralization

2020 ◽  
Vol 21 (16) ◽  
pp. 5822
Author(s):  
Viviana M. Berthoud ◽  
Junyuan Gao ◽  
Peter J. Minogue ◽  
Oscar Jara ◽  
Richard T. Mathias ◽  
...  
Keyword(s):  
Gap Junction ◽  
Lens Fiber ◽  
Lens Fiber Cell ◽  
Alizarin Red ◽  
General Process ◽  
Fiber Cells ◽  
Gap Junctional Communication ◽  
Junctional Communication ◽  
Gap Junctional ◽  
Junction Proteins

Gap junction-mediated intercellular communication facilitates the circulation of ions, small molecules, and metabolites in the avascular eye lens. Mutants of the lens fiber cell gap junction proteins, connexin46 (Cx46) and connexin50 (Cx50), cause cataracts in people and in mice. Studies in mouse models have begun to elucidate the mechanisms by which these mutants lead to cataracts. The expression of the dominant mutants causes severe decreases in connexin levels, reducing the gap junctional communication between lens fiber cells and compromising the lens circulation. The impairment of the lens circulation results in several changes, including the accumulation of Ca2+ in central lens regions, leading to the formation of precipitates that stain with Alizarin red. The cataract morphology and the distribution of Alizarin red-stained material are similar, suggesting that the cataracts result from biomineralization within the organ. In this review, we suggest that this may be a general process for the formation of cataracts of different etiologies.

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