scholarly journals Thymus hirtus sp. algeriensis Boiss. and Reut. volatile oil enhances TRAIL/Apo2L induced apoptosis and inhibits colon carcinogenesis through upregulation of death receptor pathway

Aging ◽  
2021 ◽  
Author(s):  
Fatma Guesmi ◽  
Sahdeo Prasad ◽  
Manel Ben Ali ◽  
Ismail A. Ismail ◽  
Ahmed Landoulsi
Keyword(s):  
Death Receptor ◽  
Colon Carcinogenesis ◽  
Volatile Oil ◽  
Death Receptor Pathway ◽  
Induced Apoptosis

scholarly journals The Fas/Fas Ligand Death Receptor Pathway Contributes to Phenylalanine-Induced Apoptosis in Cortical Neurons

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e71553 ◽  
Author(s):  
Xiaodong Huang ◽  
Zhaohui Lu ◽  
Zhongwei Lv ◽  
Tingting Yu ◽  
Peirong Yang ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Fas Ligand ◽  
Death Receptor ◽  
Death Receptor Pathway ◽  
Induced Apoptosis

scholarly journals Caspase Activation by Adenovirus E4orf4 Protein Is Cell Line Specific and Is Mediated by the Death Receptor Pathway

2001 ◽  
Vol 75 (2) ◽  
pp. 789-798 ◽  
Author(s):  
Adi Livne ◽  
Ronit Shtrichman ◽  
Tamar Kleinberger
Keyword(s):  
Death Receptor ◽  
Dominant Negative ◽  
Disulfonic Acid ◽  
Ros Generation ◽  
Caspase 8 ◽  
Dependent Manner ◽  
Caspase Activation ◽  
Apoptotic Pathway ◽  
Death Receptor Pathway ◽  
Induced Apoptosis

ABSTRACT Adenovirus E4orf4 protein has been shown to induce transformed cell-specific, protein phosphatase 2A-dependent, and p53-independent apoptosis. It has been further reported that the E4orf4 apoptotic pathway is caspase-independent in CHO cells. Here, we show that E4orf4 induces caspase activation in the human cell lines H1299 and 293T. Caspase activation is required for apoptosis in 293T cells, but not in H1299 cells. Dominant negative mutants of caspase-8 and the death receptor adapter protein FADD/MORT1 inhibit E4orf4-induced apoptosis in 293T cells, suggesting that E4orf4 activates the death receptor pathway. Cytochrome c is released into the cytosol in E4orf4-expressing cells, but caspase-9 is not required for induction of apoptosis. Furthermore, E4orf4 induces accumulation of reactive oxygen species (ROS) in a caspase-8- and FADD/MORT1-dependent manner, and inhibition of ROS generation by 4,5-dihydroxy-1,3-benzene-disulfonic acid (Tiron) inhibits E4orf4-induced apoptosis. Thus, our results demonstrate that E4orf4 engages the death receptor pathway to generate at least part of the molecular events required for E4orf4-induced apoptosis.

Celastrol enhances TRAIL-induced apoptosis in human glioblastoma via the death receptor pathway

2019 ◽  
Vol 84 (4) ◽  
pp. 719-728 ◽  
Author(s):  
Zhe Cha ◽  
Jianzhang Cheng ◽  
Hui Xiang ◽  
Jingjing Qin ◽  
Yujia He ◽  
...  
Keyword(s):  
Death Receptor ◽  
Human Glioblastoma ◽  
Death Receptor Pathway ◽  
Induced Apoptosis
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