scholarly journals Tumors with unmethylated MLH1 and the CpG island methylator phenotype are associated with a poor prognosis in stage II colorectal cancer patients

Oncotarget ◽  
2016 ◽  
Vol 7 (52) ◽  
pp. 86480-86489 ◽  
Author(s):  
Tao Fu ◽  
Yanliang Liu ◽  
Kai Li ◽  
Weiwei Wan ◽  
Emmanouil P. Pappou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Cpg Island ◽  
Stage Ii ◽  
Cpg Island Methylator Phenotype ◽  
Stage Ii Colorectal Cancer ◽  
Methylator Phenotype ◽  
Colorectal Cancer Patients

scholarly journals Promoter CpG island methylation of RET predicts poor prognosis in stage II colorectal cancer patients

2014 ◽  
Vol 8 (3) ◽  
pp. 679-688 ◽  
Author(s):  
Muriel X.G. Draht ◽  
Kim M. Smits ◽  
Benjamin Tournier ◽  
Valerie Jooste ◽  
Caroline Chapusot ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Cpg Island ◽  
Stage Ii ◽  
Stage Ii Colorectal Cancer ◽  
Cpg Island Methylation ◽  
Colorectal Cancer Patients

scholarly journals Prognostic and Predictive Value of CpG Island Methylator Phenotype in Patients with Locally Advanced Nonmetastatic Sporadic Colorectal Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Yuwei Wang ◽  
Yadong Long ◽  
Ye Xu ◽  
Zuqing Guan ◽  
Peng Lian ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Cpg Island ◽  
Locally Advanced ◽  
Stage Ii ◽  
Sporadic Colorectal Cancer ◽  
Cpg Island Methylator Phenotype ◽  
Methylator Phenotype ◽  
Colorectal Cancer Patients

Purpose. In the present study, the prognostic significance of CpG island methylator phenotype (CIMP) in stage II/III sporadic colorectal cancer was evaluated using a five-gene panel.Methods. Fifty stage II/III colorectal cancer patients who received radical resection were included in this study. Promoter methylation of p14ARF, hMLH1, p16INK4a, MGMT, and MINT1 was determined by methylation specific polymerase chain reaction (MSP). CIMP positive was defined as hypermethylation of three or more of the five genes. Impact factors on disease-free survival (DFS) and overall survival (OS) were analyzed using Kaplan-Meier method (log-rank test) and adjusted Cox proportional hazards model.Results. Twenty-four percent (12/50) of patients were characterized as CIMP positive. Univariate analysis showed stage III (P=0.049) and CIMP positive (P=0.014) patients who had significantly inferior DFS. In Cox regression analysis, CIMP positive epigenotype was independently related with poor DFS with HR = 2.935 and 95% CI: 1.193–7.220 (P=0.019). In patients with CIMP positive tumor, those receiving adjuvant chemotherapy had a poor DFS than those without adjuvant chemotherapy (P=0.023).Conclusions. CIMP positive was significantly correlated with decreased DFS in stage II/III colorectal cancer. Patients with CIMP positive locally advanced sporadic colorectal cancers may not benefit from 5-fluorouracil based adjuvant chemotherapy.

Abstract 4798: CpG island methylator phenotype (CIMP) in Puerto Rican Hispanic colorectal cancer patients

2011 ◽  
Author(s):  
Raul D. Bernabe-Dones ◽  
Marcia R. Cruz-Correa ◽  
Cristina I. Castro ◽  
Mercedes Y. Lacourt ◽  
Heriberto Rodriguez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Puerto Rican ◽  
Cancer Patients ◽  
Cpg Island ◽  
Cpg Island Methylator Phenotype ◽  
Methylator Phenotype ◽  
Colorectal Cancer Patients

scholarly journals Non‐invasive metastasis prognosis from plasma metabolites in stage II colorectal cancer patients: The DACHS study

2019 ◽  
Vol 145 (1) ◽  
pp. 221-231 ◽  
Author(s):  
Inna Zaimenko ◽  
Carsten Jaeger ◽  
Hermann Brenner ◽  
Jenny Chang‐Claude ◽  
Michael Hoffmeister ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Stage Ii ◽  
Plasma Metabolites ◽  
Non Invasive ◽  
Stage Ii Colorectal Cancer ◽  
Colorectal Cancer Patients

The role of adjuvant chemotherapy in stage II colorectal cancer patients

2014 ◽  
Vol 29 (10) ◽  
pp. 1237-1243 ◽  
Author(s):  
Hung-Hsin Lin ◽  
Yu-Yao Chang ◽  
Jen-Kou Lin ◽  
Jeng-Kai Jiang ◽  
Chun-Chi Lin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Stage Ii ◽  
Stage Ii Colorectal Cancer ◽  
Colorectal Cancer Patients

scholarly journals Genomic Classifier ColoPrint Predicts Recurrence in Stage II Colorectal Cancer Patients More Accurately Than Clinical Factors

2015 ◽  
Vol 20 (2) ◽  
pp. 127-133 ◽  
Author(s):  
Scott Kopetz ◽  
Josep Tabernero ◽  
Robert Rosenberg ◽  
Zhi‐Qin Jiang ◽  
Víctor Moreno ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Stage Ii ◽  
Clinical Factors ◽  
Stage Ii Colorectal Cancer ◽  
Colorectal Cancer Patients
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