scholarly journals The prognostic significance of postoperative neutrophil-to-lymphocyte ratio after radical prostatectomy for localized prostate cancer

Oncotarget ◽  
2016 ◽  
Vol 8 (7) ◽  
pp. 11778-11787 ◽  
Author(s):  
Won Sik Jang ◽  
Kang Su Cho ◽  
Myung Soo Kim ◽  
Cheol Yong Yoon ◽  
Dong Hyuk Kang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Prognostic Significance ◽  
Neutrophil To Lymphocyte Ratio ◽  
Localized Prostate Cancer ◽  
Lymphocyte Ratio

scholarly journals Prognostic significance of neutrophil-to-lymphocyte ratio in prostate cancer: evidence from 16,266 patients

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Xiaobin Gu ◽  
Xianshu Gao ◽  
Xiaoying Li ◽  
Xin Qi ◽  
Mingwei Ma ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Significance ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals Lack of an Association between Neutrophil-to-Lymphocyte Ratio and PSA Failure of Prostate Cancer Patients Who Underwent Radical Prostatectomy

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Yoko Maeda ◽  
Takashi Kawahara ◽  
Mitsuyuki Koizumi ◽  
Hiroki Ito ◽  
Yohei Kumano ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Characteristic Curve ◽  
Tumor Grade ◽  
Receiver Operator Characteristic Curve ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Resection Margin Status ◽  
Complete Blood Counts

Introduction. The neutrophil-to-lymphocyte ratio (NLR), which can be easily calculated from routine complete blood counts of the peripheral blood, has been suggested to serve as a prognostic factor for some solid malignancies. In the present study, we aimed to determine the relationship between NLR in prostate cancer patients undergoing radical prostatectomy (RP) and their prognosis.Materials and Methods. We assessed NLR in 73 men (patients) who received RP for their prostate cancer. We also performed immunohistochemistry for CD8 and CD66b in a separate set of RP specimens.Results. The median NLR in the 73 patients was 1.85. There were no significant correlations of NLR with tumor grade (p=0.834), pathological T stage (p=0.082), lymph node metastasis (p=0.062), or resection margin status (p=0.772). Based on the area under the receiver operator characteristic curve (AUROC) to predict biochemical recurrence after RP, potential NLR cut-off point was determined to be 2.88 or 3.88. However, both of these cut-off points did not precisely predict the prognosis. There were no statistically significant differences in the number of CD66b-positive neutrophils or CD8-positive lymphocytes between stromal tissues adjacent to cancer glands and stromal tissues away from cancer glands and between different grades or stages of tumors.Conclusions. There was no association between NLR and biochemical failure after prostatectomy.

Can we use neutrophil to lymphocyte ratio in the diagnosis and prediction of extracapsular extension in localized prostate cancer?

2021 ◽  
pp. 039156032110148
Author(s):  
Erkan Merder ◽  
Ahmet Arıman ◽  
Selvi Dinçer ◽  
Fatih Altunrende
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Neutrophil To Lymphocyte Ratio ◽  
Localized Prostate Cancer ◽  
Extracapsular Extension ◽  
Lymphocyte Ratio ◽  
Pathologic Stage ◽  
Free Psa

Purpose: We investigated role of neutrophil-to-lymphocyte ratio (NLR) in the diagnosis and prediction of extracapsular extension (ECE) in clinically localized prostate cancer (PCa). Materials and methods: A total of 396 patients with clinically localized PCa who underwent open radical retropubic prostatectomy (RRP), and 260 patients with benign prostatic hyperplasia (BPH) who underwent suprapubic prostatectomy were included in the study. Preoperative NLR, prostate specific antigen (PSA), prostate specific antigen density (PSAD), free PSA, prostate volume (PV), free/total PSA (f/t PSA) in both groups, and relation of NLR with PSA, Gleason Score (GS), and pathologic stage in PCa group were investigated. Records of patients were analyzed retrospectively. Results: NLR, free PSA, f/t PSA, and PV were statistically higher in BHP, and PSAD was higher in PCa group. In PCa group, NLR was found to be higher in patients with PSA >10 ng/ml compared to those with less than ⩽10 ng/ml. NLR increases as the preoperative GS increases, and it was higher in pT3 patients than pT2 patients. NLR was statistically higher in those patients with positive lymph nodes than those without after RRP ( p = 0.029). Conclusion: NLR is not a sufficient biomarker in differentiating clinically localized PCa from BPH. NLR increases as preoperative GS and pathologic stage increases. Lymph node involved patients after RRP have statistically higher NLR. NLR can be an indicator of ECE and lymph-node involvement in clinically localized PCa.

Sign in / Sign up

Export Citation Format

Share Document