scholarly journals Effect of postmastectomy radiotherapy on triple-negative breast cancer with T1-2 and 1-3 positive axillary lymph nodes: a population-based study using the SEER 18 database

Oncotarget ◽  
2019 ◽  
Vol 10 (50) ◽  
pp. 5245-5252
Author(s):  
Jie Zhang ◽  
Xiao-Xiao Wang ◽  
Jun-Yu Lian ◽  
Chuan-Gui Song
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Population Based ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Population Based Study ◽  
Postmastectomy Radiotherapy

Prognostic Significance of the Number of Negative Axillary Lymph Nodes in Patients with pT1-2 N0 M0 Breast Cancer: A Population-Based Study

2010 ◽  
pp. no-no
Author(s):  
David Martinez-Ramos ◽  
Javier Escrig-Sos ◽  
Ana Torrella-Ramos ◽  
Miguel Alcalde-Sanchez ◽  
Jose Luis Salvador-Sanchis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Prognostic Significance ◽  
Population Based ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Population Based Study

scholarly journals Systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Fangfang Liu ◽  
Thomas Hardiman ◽  
Kailiang Wu ◽  
Jelmar Quist ◽  
Patrycja Gazinska ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Immune Responses ◽  
Lymph Nodes ◽  
Triple Negative ◽  
Tumor Infiltrating Lymphocytes ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Her2 Positive ◽  
Local Immunity ◽  
Infiltrating Lymphocytes

AbstractThe level of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative (TNBC) and HER2-positive breast cancers convey prognostic information. The importance of systemic immunity to local immunity is unknown in breast cancer. We previously demonstrated that histological alterations in axillary lymph nodes (LNs) carry clinical relevance. Here, we capture local immune responses by scoring TILs at the primary tumor and systemic immune responses by recording the formation of secondary follicles, also known as germinal centers, in 2,857 cancer-free and involved axillary LNs on haematoxylin and eosin (H&E) stained sections from a retrospective cohort of 161 LN-positive triple-negative and HER2-positive breast cancer patients. Our data demonstrate that the number of germinal center formations across all cancer-free LNs, similar to high levels of TILs, is associated with a good prognosis in low TILs TNBC. This highlights the importance of assessing both primary and LN immune responses for prognostication and for future breast cancer research.

Postmastectomy Radiotherapy in T1–2 Women Breast Cancer Patients with 1–3 Positive Axillary Lymph Nodes: A Propensity Score Matched SEER Analysis

2020 ◽  
Author(s):  
Gang Xu ◽  
Shanshan Bu ◽  
Xiushen Wang ◽  
Hong Ge
Keyword(s):  
Breast Cancer ◽  
Propensity Score ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Breast Cancer Patients ◽  
Cancer Specific Survival ◽  
Postmastectomy Radiotherapy ◽  
Positive Lymph Nodes

Abstract Purpose: The application of postmastectomy radiotherapy (PMRT) in T1–2 women breast cancer patients with 1–3 positive lymph nodes has been controversial. We sought to determine the survival benefits of PMRT in the patients with T1–2 and 1–3 positive nodes.Methods: A retrospective study using the Surveillance, Epidemiology, and End Results (SEER) Regs Custom Data (with additional treatment fields) from 2001 to 2011 was performed. Patients who received PMRT were matched by the propensity score with patients who did not receive PMRT. The Overall survival (OS) and breast cancer-specific survival (BCSS) were analyzed. Results: We identified 56,725 women breast cancer patients with T1–2 and 1–3 positive nodes, and 18,646 patients were included in the analysis. After propensity score matching (1:1), with a median follow-up of 116 months, PMRT showed an increase in the OS (P = 0.018) but had no effect on the BCSS. The 10-year OS rates were 76.8% and 74.4%, and the 10-year BCSS rates were 82.8% and 82.2% for the patients who received and who did not receive PMRT, respectively. Only patients with 3 positive nodes could gain the benefit of PMRT for BCSS.Conclusion: PMRT for patients with T1–2 and 1–3 positive lymph nodes could increase the 10-year OS, and had no effect on the 10-year BCSS. Subgroup analysis indicated that only patients with 3 positive lymph nodes could benefit from PMRT for both the OS and BCSS.

scholarly journals Opportunities for improving triple-negative breast cancer outcomes: results of a population-based study

2017 ◽  
Vol 6 (3) ◽  
pp. 526-536 ◽  
Author(s):  
Elisabetta Rapiti ◽  
Kim Pinaud ◽  
Pierre O. Chappuis ◽  
Valeria Viassolo ◽  
Aurélie Ayme ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Population Based ◽  
Cancer Outcomes ◽  
Population Based Study ◽  
Breast Cancer Outcomes

scholarly journals Effect of nodal status on clinical outcomes of triple-negative breast cancer: a population-based study using the SEER 18 database

Oncotarget ◽  
2016 ◽  
Vol 7 (29) ◽  
pp. 46636-46645 ◽  
Author(s):  
Xiao-Xiao Wang ◽  
Yi-Zhou Jiang ◽  
Jun-Jing Li ◽  
Chuan-Gui Song ◽  
Zhi-Ming Shao
Keyword(s):  
Breast Cancer ◽  
Clinical Outcomes ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Population Based ◽  
Nodal Status ◽  
Population Based Study
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