scholarly journals Caspase-8 inhibition represses initial human monocyte activation in septic shock model

Oncotarget ◽  
2016 ◽  
Vol 7 (25) ◽  
pp. 37456-37470 ◽  
Author(s):  
Maria Jose Oliva-Martin ◽  
Luis Ignacio Sanchez-Abarca ◽  
Johanna Rodhe ◽  
Alejandro Carrillo-Jimenez ◽  
Pinelopi Vlachos ◽  
...  
Keyword(s):  
Septic Shock ◽  
Human Monocyte ◽  
Caspase 8 ◽  
Shock Model ◽  
Monocyte Activation

scholarly journals Unfractionated Heparin Improves the Intestinal Microcirculation in a Canine Septic Shock Model

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Heng Zhang ◽  
Yini Sun ◽  
Xin An ◽  
Xiaochun Ma
Keyword(s):  
Septic Shock ◽  
Unfractionated Heparin ◽  
Flow Index ◽  
Shock Model ◽  
Microcirculatory Perfusion ◽  
Basic Therapy ◽  
E Coli ◽  
Intestinal Microcirculation ◽  
Hemodynamic Variables ◽  
Lactate Levels

Background. Alterations of microcirculation are associated with organ hypoperfusion and high mortality in septic shock. This study is aimed at investigating the effects of unfractionated heparin (UFH) on intestinal microcirculatory perfusion and systemic circulation in a septic shock model. Methods. Twenty-four beagle dogs were randomly allocated into four groups: (a) sham group: healthy controls, (b) shock group: septic shock induced by Escherichia coli, (c) basic therapy group: septic shock animals treated with antibiotics and 10 ml/kg/h saline, and (d) heparin group: septic shock animals treated with basic therapy plus UFH. Hemodynamic variables were measured within 24 h after E. coli administration. The intestinal microcirculation was simultaneously investigated with a sidestream dark-field imaging technique. Additionally, the function of vital organs was evaluated at 12 h postadministration (T12). Results. E. coli induced a progressive septic shock in which the mean arterial pressure (MAP) decreased and lactate levels sharply increased, accompanied by deteriorated microvessel perfusion. While basic therapy partially improved the microvascular flow index and the perfused microvessel density in the jejunal villi, UFH significantly restored major microcirculation variables at T12. Physiological variables, including MAP, urine output, and lactate levels, were improved by UFH, whereas some hemodynamic indices were not affected by UFH. With respect to organ function, UFH increased the platelet count and decreased the creatinine level. Conclusions. UFH improves microcirculatory perfusion of the small intestine independently of the changes in systemic hemodynamic variables in a canine model of septic shock, thereby improving coagulation and renal function.

scholarly journals Caspase-8 mediates inflammation and disease in rodent malaria

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Larissa M. N. Pereira ◽  
Patrícia A. Assis ◽  
Natalia M. de Araújo ◽  
Danielle F. Durso ◽  
Caroline Junqueira ◽  
...  
Keyword(s):  
Septic Shock ◽  
Human Disease ◽  
Caspase 8 ◽  
Inflammasome Activation ◽  
Plasmodium Chabaudi ◽  
Experimental Cerebral Malaria ◽  
Rodent Malaria ◽  
Canonical Pathways ◽  
Inflammatory Caspases

Abstract Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we report that caspase-8 is a central mediator of systemic inflammation, septic shock in the Plasmodium chabaudi-infected mice and the P. berghei-induced experimental cerebral malaria (ECM). Importantly, our results indicate that the combined deficiencies of caspases-8/1/11 or caspase-8/gasdermin-D (GSDM-D) renders mice impaired to produce both TNFα and IL-1β and highly resistant to lethality in these models, disclosing a complementary, but independent role of caspase-8 and caspases-1/11/GSDM-D in the pathogenesis of malaria. Further, we find that monocytes from malaria patients express active caspases-1, -4 and -8 suggesting that these inflammatory caspases may also play a role in the pathogenesis of human disease.

CONTRASTING EFFECTS OF LPS AND LTA ON HUMAN MONOCYTE ACTIVATION

2010 ◽  
Author(s):  
Susannah K. Leaver ◽  
Anna Lagan ◽  
Gregory Quinlan ◽  
Timothy W. Evans ◽  
Anne Burke-Gaffney
Keyword(s):  
Human Monocyte ◽  
Monocyte Activation

scholarly journals Impaired phagocytosis directs human monocyte activation in response to fungal derived β-glucan particles

2018 ◽  
Vol 48 (5) ◽  
pp. 757-770 ◽  
Author(s):  
Giorgio Camilli ◽  
Elif Eren ◽  
David L. Williams ◽  
Vishukumar Aimanianda ◽  
Etienne Meunier ◽  
...  
Keyword(s):  
Human Monocyte ◽  
Monocyte Activation

Blood volume measurements using an integrated fiberoptic monitoring system in a porcine septic shock model

2006 ◽  
Vol 34 (5) ◽  
pp. 1483-1488 ◽  
Author(s):  
Gernot Marx ◽  
Tobias Schuerholz ◽  
Samantha Pedder ◽  
Tim Simon ◽  
Stephen Grime ◽  
...  
Keyword(s):  
Septic Shock ◽  
Monitoring System ◽  
Blood Volume ◽  
Shock Model ◽  
Volume Measurements

Effect of Human Fibroblast Interferon on Normal Human Monocyte Activation Induced by a Factor Found in Sarcoidosis Sera

1987 ◽  
Vol 14 (4) ◽  
pp. 297-304 ◽  
Author(s):  
Toru Baba ◽  
Koji Yamaguchi ◽  
Yuji Matsushima ◽  
Minoru Hoshino ◽  
Takahiro Ochiya ◽  
...  
Keyword(s):  
Human Fibroblast ◽  
Human Monocyte ◽  
Monocyte Activation ◽  
Normal Human

Interleukin-2 and human monocyte activation

1995 ◽  
Vol 57 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Igor Espinoza-Delgado ◽  
Maria Carla Bosco ◽  
Tiziana Musso ◽  
G. Luca Gusella ◽  
Dan L. Longo ◽  
...  
Keyword(s):  
Interleukin 2 ◽  
Human Monocyte ◽  
Monocyte Activation

Skeletal muscle oedema and muscle fibre necrosis during septic shock. Observations with a porcine septic shock model

1994 ◽  
Vol 424 (6) ◽  
Author(s):  
S. Hauptmann ◽  
B. Klosterhalfen ◽  
J. Weis ◽  
C. Mittermayer ◽  
C.J. Kirkpatrick
Keyword(s):  
Skeletal Muscle ◽  
Septic Shock ◽  
Muscle Fibre ◽  
Shock Model

scholarly journals Protective effect of CDP-choline on hypotension and tissue injury in septic shock model

2017 ◽  
Vol 64 (2) ◽  
pp. 103-110 ◽  
Author(s):  
SEVİM Çiğdem; ALTINBAŞ
Keyword(s):  
Septic Shock ◽  
Protective Effect ◽  
Tissue Injury ◽  
Shock Model

ABNORMAL HUMAN MONOCYTE ACTIVATION BY CARBOHYDRATE LIGANDS ON PORCINE ENDOTHELIUM, AND REVERSAL BY OVEREXPRESSION OF FUCOSYL ??1,2 TRANSFERASE

1998 ◽  
Vol 66 (8) ◽  
pp. S26
Author(s):  
P A Kwiatkowski ◽  
J H Artrip ◽  
S F Wang ◽  
R E Michler ◽  
IFC McKenzie ◽  
...  
Keyword(s):  
Human Monocyte ◽  
Monocyte Activation ◽  
Carbohydrate Ligands
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