scholarly journals LARF: Instrumental Variable Estimation of Causal Effects through Local Average Response Functions

2016 ◽  
Vol 71 (Code Snippet 1) ◽  
Author(s):  
Weihua An ◽  
Xuefu Wang
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Arvid Sjolander ◽  
Torben Martinussen

Abstract Instrumental variables is a popular method in epidemiology and related fields, to estimate causal effects in the presence of unmeasured confounding. Traditionally, instrumental variable analyses have been confined to linear models, in which the causal parameter of interest is typically estimated with two-stage least squares. Recently, the methodology has been extended in several directions, including two-stage estimation and so-called G-estimation in nonlinear (e. g. logistic and Cox proportional hazards) models. This paper presents a new R package, ivtools, which implements many of these new instrumental variable methods. We briefly review the theory of two-stage estimation and G-estimation, and illustrate the functionality of the ivtools package by analyzing publicly available data from a cohort study on vitamin D and mortality.


2015 ◽  
Vol 46 (2) ◽  
pp. 155-188 ◽  
Author(s):  
Peter M. Steiner ◽  
Yongnam Kim ◽  
Courtney E. Hall ◽  
Dan Su

Randomized controlled trials (RCTs) and quasi-experimental designs like regression discontinuity (RD) designs, instrumental variable (IV) designs, and matching and propensity score (PS) designs are frequently used for inferring causal effects. It is well known that the features of these designs facilitate the identification of a causal estimand and, thus, warrant a causal interpretation of the estimated effect. In this article, we discuss and compare the identifying assumptions of quasi-experiments using causal graphs. The increasing complexity of the causal graphs as one switches from an RCT to RD, IV, or PS designs reveals that the assumptions become stronger as the researcher’s control over treatment selection diminishes. We introduce limiting graphs for the RD design and conditional graphs for the latent subgroups of compliers, always takers, and never takers of the IV design, and argue that the PS is a collider that offsets confounding bias via collider bias.


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