scholarly journals Efficacy of Lozartan and Enalapril in mild-to-moderate hypertensive patients with different polymorphisms of type 2 bradykinin receptor and angiotensinogene genes

2007 ◽  
Vol 13 (1) ◽  
pp. 61-68
Author(s):  
S. N. Shulenin ◽  
A. N. Kuchmin ◽  
M. V. Zubakova
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Receptor Gene ◽  
Left Ventricular ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
Pressure Monitoring ◽  
Hypertensive Patients ◽  
Bradykinin Receptor

The aim of the study was to investigate the influence of bradykinin type 2 receptor and angiotensinogen genes polymorphism on clinical features of hypertension and efficacy of the angiotensin II receptor blocker (Losartan) and ACE inhibitor (enalapril) in patients with mild-to-moderate hypertension. We examined 140 hypertensive patients; mean duration of hypertension constituted 9,3±2,7 years. Ambulatory blood pressure monitoring, ECHO-cardiography and genes polymorphism definition were done in all patients, with the repeated blood pressure monitoring used as a criteria of treatment efficacy. As a result it was determined, that blood pressure was higher in patients with T/T polymorphism of angiotensinogen gene and +9/+9 polymorphism of type 2 bradykinin receptor gene. Left ventricular mass index was higher in patients with M/M and +9/+9 polymorphisms, and the antihypertensive effect of the drugs was higher in patients with +9/+9 polymorphism.

The effects of nocturnal dipping on cardiovascular outcomes and proteinuria in essential hypertensive patients

Open Medicine ◽  
2008 ◽  
Vol 3 (3) ◽  
pp. 279-286 ◽  
Author(s):  
Yusuf Selcoki ◽  
Burak Uz ◽  
Nuket Baybek ◽  
Ali Akcay ◽  
Beyhan Eryonucu
Keyword(s):  
Blood Pressure ◽  
Ambulatory Blood Pressure Monitoring ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Left Ventricular ◽  
Pressure Monitoring ◽  
Hypertensive Patients ◽  
Spot Urine

AbstractIndividuals who do not have a 10% to 20% reduction in blood pressure (BP) during the night are known as ‘nondippers’. Non-dipping patterns in hypertensive patients have been shown to be associated with an excess of target organ damage and other adverse outcomes. The present study was designed to investigate the relationship between nocturnal BP pattern, defined on the basis of the ambulatory blood pressure monitoring (ABPM) recording, and cardiac and renal target organ damage in a population of at least one year treated essential hypertensive subjects. The present analysis involved 123 patients with treated essential hypertension attending the outpatient clinic of our centre. Each patient was subjected to the following procedures: blood sampling for routine blood chemistry, spot urine for proteinuria, 24-hour periods of ABPM, and echocardiography. In the ABPM period, a dipping pattern was observed in 65 of the 123 patients, and a non-dipping pattern in 58 patients. Body mass index was higher in the non-dippers (26 ± 4 versus 28 ± 4, p<0.05). The proteinuria in spot urine was significantly higher in the non-dippers (10 ± 6 versus 24 ± 48, p<0.03). Left ventricular mass, interventricular septum thickness, posterior wall thickness and left ventricular systolic diameter were significantly higher in the non-dippers compared to the dippers. Left ventricular diastolic function was similar in non-dipper cases, except E-wave deceleration time. In treated essential hypertensives the blunted or absent nocturnal fall in blood pressure can be a strong predictor of cardiac and renal events. Hypertensive patients should be evaluated by ambulatory blood pressure monitoring. To prevent patients at risk for morbidity and mortality casualities as a result of hypertension, patients should be evaluated by ambulatory blood pressure monitoring. This method can be utilized for exacting future follow-ups with the patient.

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