scholarly journals Perbandingan Kualitas Hidup Antara Pasien DRESS (Drug Reaction With Eosinophilia and Systemic Symptom) dan SJS (Stevens Johnson Syndrome) / TEN (Toxic Epidermal Necrolysis) Akibat Penggunaan Obat Di RSUP Dr. Sardjito Yogyakarta

2020 ◽  
Vol 5 (1) ◽  
pp. 5
Author(s):  
Ratna Septi Tristiana
Keyword(s):  
Drug Reaction ◽  
Toxic Epidermal Necrolysis ◽  
Stevens Johnson Syndrome ◽  
Systemic Symptom ◽  
Johnson Syndrome

The association between HLA-B*15:02 and phenytoin-induced severe cutaneous adverse reactions: a meta-analysis

2021 ◽  
Author(s):  
Thanh Huong Phung ◽  
Khanh Ngoc Cong Duong ◽  
Mac Ardy Junio Gloria ◽  
Thien Khac Nguyen
Keyword(s):  
Drug Reaction ◽  
Adverse Reactions ◽  
Meta Analysis ◽  
Stevens Johnson Syndrome ◽  
Random Effects Model ◽  
Systemic Symptom ◽  
Anticonvulsant Agent ◽  
Johnson Syndrome ◽  
Severe Cutaneous Adverse Reactions ◽  
Cutaneous Adverse Reactions

Aim: Phenytoin (PHT) is a common anticonvulsant agent known for inducing severe cutaneous adverse reactions (SCARs). HLA-B*15:02 as a risk factor of PHT-induced SCARs was reported in numerous studies with inconsistent results. This meta-analysis aimed to establish pooling evidence of this association. Materials & methods: Pooled odds ratios (ORs) with 95% CIs were estimated using a random-effects model. Results: A total of 11 studies on 1389 patients, were included for the analyses. There was a significant association between HLA-B*15:02 and PHT-induced SCAR (pooled OR = 2.29, 95% CI: 1.25–4.19, p = 0.008). Furthermore, there was a significant association regarding Stevens–Johnson syndrome/toxic epidermal necrolysis (OR = 3.63, 95% CI: 2.15–6.13, p < 0.001) but no association regarding drug reaction with eosinophilia and systemic symptom. Conclusion: The results supported the recommendations of HLA-B*15:02 screening before treatment with PHT.

TOXIC EPIDERMOLYSIS CAUSED BY ANTIEPILEPTIC DRUGS: CLINICAL OBSERVATIONS

2021 ◽  
Vol 100 (1) ◽  
pp. 282-287
Author(s):  
M.A. Ufimtseva ◽  
◽  
M.A. Zakharov ◽  
O.Yu. Averyanov ◽  
O.V. Kozhevnikova ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Toxic Epidermal Necrolysis ◽  
Antiepileptic Drugs ◽  
Stevens Johnson Syndrome ◽  
International Literature ◽  
Emergency Medical Care ◽  
Clinical Observations ◽  
Johnson Syndrome

Toxic epidermal necrolysis (Lyell's syndrome) and Stevens–Johnson syndrome are severe types of toxicodermia and require emergency medical care. The pathophysiology of toxicoderma is associated with an adverse drug reaction. The article provides data from Russian and international literature on the role of antiepileptic drugs in these diseases occurrence. It also presents clinical cases of toxic epidermal necrolysis in children caused by anticonvulsants intake.

Pediatric SJS/TEN Subdued by a Combination of Dexamethasone, Cyclosporine, and Etanercept

2019 ◽  
Vol 23 (5) ◽  
pp. 547-550 ◽  
Author(s):  
Jérôme Coulombe ◽  
Eugénie Belzile ◽  
Amélie Duhamel ◽  
Pauline Rault ◽  
Chantal Buteau ◽  
...  
Keyword(s):  
Drug Reaction ◽  
Toxic Epidermal Necrolysis ◽  
Triple Therapy ◽  
Late Onset ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome

We report a case of an 17-year-old male with a drug reaction in the spectrum of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), triggered by carbamazepine, who was succesfully treated with the combination of dexamethasone, cyclosporine, and etanercept. This triple therapy halted and prevented skin epidermolysis without immediate or late onset complications.

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