scholarly journals Quality of Life of Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) and Stevens-Johnson Syndrome (SJS) and/or Toxic Epidermal Necrolysis (TEN) Patients

2021 ◽  
Vol Volume 15 ◽  
pp. 329-335
Author(s):  
Dyah Aryani Perwitasari ◽  
Sri Awalia Febriana ◽  
Ratna Septi Tristiana
Keyword(s):  
Quality Of Life ◽  
Drug Reaction ◽  
Toxic Epidermal Necrolysis ◽  
Stevens Johnson Syndrome ◽  
Systemic Symptom ◽  
Johnson Syndrome

Major psychological complications and decreased health-related quality of life among survivors of Stevens-Johnson syndrome and toxic epidermal necrolysis

2016 ◽  
Vol 175 (2) ◽  
pp. 422-424 ◽  
Author(s):  
R.P. Dodiuk-Gad ◽  
C. Olteanu ◽  
A. Feinstein ◽  
R. Hashimoto ◽  
R. Alhusayen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Toxic Epidermal Necrolysis ◽  
Stevens Johnson Syndrome ◽  
Health Related Quality ◽  
Johnson Syndrome ◽  
Related Quality ◽  
Health Related

scholarly journals Clinical Aspects of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis With Severe Ocular Complications in India

2021 ◽  
Vol 8 ◽  
Author(s):  
Swapna S. Shanbhag ◽  
Virender S. Sangwan ◽  
Aastha Singh ◽  
Pragnya R. Donthineni ◽  
Sayan Basu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Toxic Epidermal Necrolysis ◽  
Acute Phase ◽  
Chronic Phase ◽  
Stevens Johnson Syndrome ◽  
Clinical Aspects ◽  
Ocular Involvement ◽  
Ocular Complications ◽  
Johnson Syndrome

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a spectrum of rare, severe immunological blistering skin reactions which are triggered by medication intake or infections. The acute phase is characterized by necrolysis of the skin and desquamation of mucosa, primarily oral and ocular, with significant mortality rates. The chronic phase is characterized by multi-organ sequelae with increased rates of morbidity and reduced quality of life for patients who have survived the acute phase. Since the primary goal in the acute phase is saving the life of the patient, ocular involvement is often missed and a significant proportion of patients present to an ophthalmologist with the chronic ocular sequelae. In India, chronic ocular sequelae and low vision are observed in two-thirds of patients who present in the chronic phase of SJS/TEN. In the chronic phase of ocular involvement, there are definite windows of opportunity which if targeted with specific interventions such as scleral lenses and mucous membrane grafts can help reduce the incidence of corneal blindness and improve the quality of life for patients with SJS/TEN. Over the last decade, several studies from India have advanced the understanding of the natural course of ocular involvement in SJS/TEN and the outcomes of timely interventions in the chronic phase of the disease. We present an overview of the epidemiology of ocular complications of SJS/TEN in India, the specific challenges faced in the management of ocular complications in the acute stage and recent advances in management of the chronic ocular complications of the disease.

The association between HLA-B*15:02 and phenytoin-induced severe cutaneous adverse reactions: a meta-analysis

2021 ◽  
Author(s):  
Thanh Huong Phung ◽  
Khanh Ngoc Cong Duong ◽  
Mac Ardy Junio Gloria ◽  
Thien Khac Nguyen
Keyword(s):  
Drug Reaction ◽  
Adverse Reactions ◽  
Meta Analysis ◽  
Stevens Johnson Syndrome ◽  
Random Effects Model ◽  
Systemic Symptom ◽  
Anticonvulsant Agent ◽  
Johnson Syndrome ◽  
Severe Cutaneous Adverse Reactions ◽  
Cutaneous Adverse Reactions

Aim: Phenytoin (PHT) is a common anticonvulsant agent known for inducing severe cutaneous adverse reactions (SCARs). HLA-B*15:02 as a risk factor of PHT-induced SCARs was reported in numerous studies with inconsistent results. This meta-analysis aimed to establish pooling evidence of this association. Materials & methods: Pooled odds ratios (ORs) with 95% CIs were estimated using a random-effects model. Results: A total of 11 studies on 1389 patients, were included for the analyses. There was a significant association between HLA-B*15:02 and PHT-induced SCAR (pooled OR = 2.29, 95% CI: 1.25–4.19, p = 0.008). Furthermore, there was a significant association regarding Stevens–Johnson syndrome/toxic epidermal necrolysis (OR = 3.63, 95% CI: 2.15–6.13, p < 0.001) but no association regarding drug reaction with eosinophilia and systemic symptom. Conclusion: The results supported the recommendations of HLA-B*15:02 screening before treatment with PHT.

Physical and Psychological Recovery Following Toxic Epidermal Necrolysis: A Patient Survey

2021 ◽  
Author(s):  
Katherine L DeNiro ◽  
Shari Honari ◽  
Dan S Hippe ◽  
Andrea Dai ◽  
Tam N Pham ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Toxic Epidermal Necrolysis ◽  
Survival Rates ◽  
Multidisciplinary Care ◽  
Patient Survey ◽  
Stevens Johnson Syndrome ◽  
Multidisciplinary Care Team ◽  
Related Quality

Abstract Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are acute, life-threatening diseases that cause sloughing of the skin and mucous membranes. Despite improved survival rates, few studies focus on long-term outcomes. We conducted a single-center review of all patients with SJS/TEN admitted from January 2008-2014. SJS/TEN survivors were invited to participate in the validated Veterans RAND 12 Item Health Survey (VR-12) to assess health related quality of life using a mental health composite score (MCS) and physical health component score (PCS). The sample was compared to US norms using one sample two tailed t-tests. A second questionnaire addressed potential long-term medical complications related to SJS/TEN. Of 81 treated subjects, 24 (30%) long-term survivors responded. Participants identified cutaneous sequelae most frequently (79%), followed by nail problems (70%), oral (62%) and ocular (58%) sequalae. Thirty-eight percent rated their quality of life to be “unchanged” to “much better” since their episode of SJS/TEN. The average PCS score was lower than US population norms (mean: 36 vs. 50, p=0.006), indicating persistent physical sequelae from SJS/TEN. These results suggest that SJS/TEN survivors continue to suffer from long-term complications that impair their quality of life and warrant ongoing follow-up by a multidisciplinary care team.

scholarly journals Correction to: Adverse drug reaction causality assessment tools for drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: room for improvement

2019 ◽  
Vol 75 (9) ◽  
pp. 1331-1331
Author(s):  
Jennifer L. Goldman ◽  
Wen-Hung Chung ◽  
Brian R. Lee ◽  
Chun-Bing Chen ◽  
Chun-Wei Lu ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Toxic Epidermal Necrolysis ◽  
Causality Assessment ◽  
Assessment Tools ◽  
Stevens Johnson Syndrome ◽  
Drug Induced ◽  
Johnson Syndrome

TOXIC EPIDERMOLYSIS CAUSED BY ANTIEPILEPTIC DRUGS: CLINICAL OBSERVATIONS

2021 ◽  
Vol 100 (1) ◽  
pp. 282-287
Author(s):  
M.A. Ufimtseva ◽  
◽  
M.A. Zakharov ◽  
O.Yu. Averyanov ◽  
O.V. Kozhevnikova ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Toxic Epidermal Necrolysis ◽  
Antiepileptic Drugs ◽  
Stevens Johnson Syndrome ◽  
International Literature ◽  
Emergency Medical Care ◽  
Clinical Observations ◽  
Johnson Syndrome

Toxic epidermal necrolysis (Lyell's syndrome) and Stevens–Johnson syndrome are severe types of toxicodermia and require emergency medical care. The pathophysiology of toxicoderma is associated with an adverse drug reaction. The article provides data from Russian and international literature on the role of antiepileptic drugs in these diseases occurrence. It also presents clinical cases of toxic epidermal necrolysis in children caused by anticonvulsants intake.

Pediatric SJS/TEN Subdued by a Combination of Dexamethasone, Cyclosporine, and Etanercept

2019 ◽  
Vol 23 (5) ◽  
pp. 547-550 ◽  
Author(s):  
Jérôme Coulombe ◽  
Eugénie Belzile ◽  
Amélie Duhamel ◽  
Pauline Rault ◽  
Chantal Buteau ◽  
...  
Keyword(s):  
Drug Reaction ◽  
Toxic Epidermal Necrolysis ◽  
Triple Therapy ◽  
Late Onset ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome

We report a case of an 17-year-old male with a drug reaction in the spectrum of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), triggered by carbamazepine, who was succesfully treated with the combination of dexamethasone, cyclosporine, and etanercept. This triple therapy halted and prevented skin epidermolysis without immediate or late onset complications.

scholarly journals Adverse drug reaction causality assessment tools for drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: room for improvement

2019 ◽  
Vol 75 (8) ◽  
pp. 1135-1141 ◽  
Author(s):  
Jennifer L. Goldman ◽  
Wen-Hung Chung ◽  
Brian R. Lee ◽  
Chun-Bing Chen ◽  
Chun-Wei Lu ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Toxic Epidermal Necrolysis ◽  
Causality Assessment ◽  
Assessment Tools ◽  
Stevens Johnson Syndrome ◽  
Drug Induced ◽  
Johnson Syndrome
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