Distal Sensory Peripheral Neuropathy in HIV: A Case Study

2009 ◽  
Vol 2 (1) ◽  
pp. 13-18
Author(s):  
Joyce K. Anastasi ◽  
Janice Smolowitz ◽  
Bernadette Capili
Keyword(s):  
Human Immunodeficiency Virus ◽  
Peripheral Neuropathy ◽  
Medical Management ◽  
Educational Needs ◽  
Foot Care ◽  
Sensory Peripheral Neuropathy ◽  
Immunodeficiency Virus

Distal sensory peripheral neuropathy (DSP) is a common problem experienced with the human immunodeficiency virus (HIV). The pain associated with DSP can be severe and debilitating. Interventions used to manage DSP related to HIV have been adopted from the medical management of peripheral neuropathy secondary to diabetes. However, foot care recommendations for HIV and DSP have not been instituted unlike the diabetes literature. This article illustrates the clinical and the educational needs of individuals with HIV and DSP.

scholarly journals Distal Sensory Peripheral Neuropathy in Human Immunodeficiency Virus Type 1–Positive Individuals Before and After Antiretroviral Therapy Initiation in Diverse Resource-Limited Settings

2019 ◽  
Vol 71 (1) ◽  
pp. 158-165 ◽  
Author(s):  
Alyssa C Vecchio ◽  
Christina M Marra ◽  
Jeffrey Schouten ◽  
Hongyu Jiang ◽  
Johnstone Kumwenda ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Peripheral Neuropathy ◽  
Antiretroviral Therapy ◽  
People Living With Hiv ◽  
Older Individuals ◽  
Resource Limited Settings ◽  
Sensory Peripheral Neuropathy ◽  
Resource Limited ◽  
Immunodeficiency Virus ◽  
Living With Hiv

Abstract Background Distal sensory peripheral neuropathy (DSPN) is a complication of human immunodeficiency virus (HIV). We estimate DSPN prevalence in 7 resource-limited settings (RLSs) for combination antiretroviral therapy (cART)–naive people living with HIV (PLWH) compared with matched participants not living with HIV and in PLWH virally suppressed on 1 of 3 cART regimens. Methods PLWH with a CD4+ count <300 cells/mm3 underwent standardized neurological examination and functional status assessments before and every 24 weeks after starting cART. Matched individuals not living with HIV underwent the same examinations once. Associations between covariates with DSPN at entry were assessed using the χ2 test, and virally suppressed PLWH were assessed using generalized estimating equations. Results Before initiating cART, 21.3% of PLWH had DSPN compared with 8.5% of people not living with HIV (n = 2400; χ2(df = 1) = 96.5; P < .00001). PLWH with DSPN were more likely to report inability to work [χ2(df = 1) = 10.6; P = .001] and depression [χ2(df = 1) = 8.9; P = .003] than PLWH without DSPN. Overall prevalence of DSPN among those virally suppressed on cART decreased: 20.3%, week 48; 15.3%, week 144; and 10.3%, week 192. Incident DSPN was seen in 127 PLWH. Longitudinally, DSPN was more likely in older individuals (P < .001) and PLWH with less education (P = .03). There was no significant association between cART regimen and DSPN. Conclusions Although the prevalence of DSPN decreased following cART initiation in PLWH, further research could identify strategies to prevent or ameliorate residual DSPN after initiating cART in RLSs.

scholarly journals Transient and asymptomatic meningitis in human immunodeficiency virus-1 subtype C: a case study of genetic compartmentalization and biomarker dynamics

2018 ◽  
Vol 24 (6) ◽  
pp. 786-796 ◽  
Author(s):  
Sergio M. de Almeida ◽  
Michelli F. Oliveira ◽  
Antoine Chaillon ◽  
Indianara Rotta ◽  
Clea E. Ribeiro ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Subtype C ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

HIV-1-Associated Neuropathies

CNS Spectrums ◽  
2000 ◽  
Vol 5 (5) ◽  
pp. 66-72 ◽  
Author(s):  
Ashok Verma ◽  
Walter G. Bradley
Keyword(s):  
Chronic Pain ◽  
Human Immunodeficiency Virus ◽  
Peripheral Neuropathy ◽  
Patient Population ◽  
Peripheral Neuropathies ◽  
Toxic Neuropathy ◽  
Immunodeficiency Virus ◽  
Hiv 1 ◽  
Sensory Polyneuropathy

AbstractPeripheral neuropathy associated with human immunodeficiency virus type 1 (HIV-1) infection is a major cause of morbidity in this patient population. Due to the associated chronic pain, its management has come within the purview of neuropsychiatrists. This paper will focus on the primary pathogenic aspects of HIV-1–associated peripheral neuropathies. The specific syndromes of greatest concern are distal sensory polyneuropathy, toxic neuropathy, inflammatory demyelinating polyradiculoneuropathy, and cytomegalovirus-related progressive polyradiculoneuropathy. The treatments available for these conditions and their efficacy are discussed.

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